Sökresultat

Currently, the clinical factors affecting immune responses to influenza vaccines have not been systematically explored. The mechanism of low responsiveness to influenza vaccination (LRIV) is complicated and not thoroughly elucidated. Thus, we integrate our in-house genome-wide association studies (GWAS) analysis result of LRIV (N = 111, Ncase [Low Responders] = 34, Ncontrol [Responders] = 77) with

Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. Theprogramme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respective countriesaiming at the realization of

Background A 1-h algorithm based on high-sensitivity cardiac troponin T (hs-cTnT) testing at presentation and again 1 h thereafter has been shown to accurately rule out acute myocardial infarction. Objectives The goal of the study was to evaluate the diagnostic accuracy of the 1-h algorithm when supplemented with patient history and an electrocardiogram (ECG) (the extended algorithm) for predicti

Over the last decade, the family of galectin proteins has been identified as key regulators of important biological processes. They bind β-D-galactopyranoside residues in glycoconjugates, and by presenting multiple binding sites, within one galectin or by forming dimers or multimers, they can cross-link glycoproteins and form galectin-glycoprotein lattices. Such lattices formed on the cell surface

Objective: Previously proposed “synchronous EEG patterns” predict poor outcome within 24 h after cardiac arrest (CA). We investigate the prognostic performance of these early EEG predictors in addition to the late EEG predictors (>24 h) recommended in the European post-resuscitation guidelines. Methods: Observational substudy of the TTM2-trial including consecutive comatose resuscitated patients.

BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina

Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective

This paper presents a tool for computing thermal resistance of single U-tube ground heat exchangers placed in vertical boreholes. The tool is complete in the sense that it can compute both local and effective thermal resistances for either grouted or groundwater-filled boreholes. For grouted boreholes, it utilizes the highly accurate multipole method. For groundwater-filled boreholes, it utilizes

The past decade and a half has seen the design and execution of several ground-based spectroscopic surveys, both Galactic and Extragalactic. Additionally, new surveys are being designed that extend the boundaries of current surveys. In this context, many important considerations must be done when designing a spectrograph for the future. Among these is the determination of the optimum wavelength co

This statement examines the relation of the resting ECG to its technology. Its purpose is to foster understanding of how the modern ECG is derived and displayed and to establish standards that will improve the accuracy and usefulness of the ECG in practice. Derivation of representative waveforms and measurements based on global intervals are described. Special emphasis is placed on digital signal

It is well known that the origin of one type of spurious solutions in multiband k(.)p theory is the failure to restrict the Fourier coefficients of the envelope functions to the first Brillouin zone. Often, the set of differential equations obtained is supplemented with interfacial boundary conditions derived by integrating the differential equations across the interface; however, this leads to a

We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and the resistant strain RIIIS/J. In an effort to verify the protective effect from having two RIIIS/J alleles at eae2, the resistant locus was bred into the susceptible strain in homozygous form. However,

No rock at the Earth's surface escapes weathering. This process is the primary source of all the essential elements for organisms, except nitrogen and carbon. Since the onset of terrestrial life, weathering has been accelerated under the influence of biota. The study of biological weathering started at the end of the 19th century. Although the role of bacteria (Eubacteria, Archaea) has attracted a

Digital human modelling (DHM) is commonly utilised for vehicle and workplace design in the automotive industry. More rarely are the tools applied in the health care industry, albeit having similar objectives for cost-efficiency and User-centred design processes. The paper illustrates how a DHM tool is modified and utilised to evaluate a bathing system design from caretakers' and caregivers' ergono

Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated s

Abstract in UndeterminedTargeted proteomics via selected reaction monitoring (SRM) is a powerful mass spectrometric technique affording higher dynamic range, increased specificity and lower limits of detection than other shotgun mass spectrometry methods when applied to proteome analyses. However, it involves selective measurement of predetermined analytes, which requires more preparation in the f