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Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation Transfer (CEST) experiments measure the transfer of magnetization from molecular protons to the solvent water protons, an effect that becomes apparent as an MRI signal loss ("saturation"). This allows molecular information to be accessed with the enhanced sensitivity of MRI. In analogy to Magnetic Resonance Spectroscopy (MRS),
Modern gas turbines always operate at a high level of inlet temperature. The current inlet temperature in the aircraft and heavy duty gas turbines is higher than the melting point of the guide vane material. Consequently, advanced cooling schemes must be developed to ensure the safe operation of gas turbines. In the current study, numerical simulations were conducted to investigate the influence o
OBJECTIVE-: The purpose of this study was to characterize a phosphorylation motif at serine 225 as a molecular switch that regulates the pressure-dependent activation of sphingosine kinase 1 (Sk1) in resistance artery smooth muscle cells. METHODS AND RESULTS-: In isolated hamster gracilis muscle resistance arteries, pressure-dependent activation/translocation of Sk1 by ERK1/2 was critically depend
Objective: The purpose of this study was to clarify the magnitude and nature of the relationship between divorce and risk for alcohol use disorder (AUD). Method: In a population-based Swedish sample of married individuals (N=942,366), the authors examined the association between divorce or widowhood and risk for first registration for AUD. AUD was assessed usingmedical, criminal, and pharmacy regi
The aim of this study was to characterise the expression of the melanocortin system in the normal and injured rat visual system. Using real-time polymerase chain reaction and immunohistochemistry, we detected melanocortin MC3, MC4 and MC5 receptors and proopiomelanocortin in adult retina and superior colliculus. Melanocortin MC4 receptor mRNA was the most abundant receptor. Melanocortin MC3, MC4 a
We report on two-particle charge-dependent correlations in pp, p–Pb, and Pb–Pb collisions as a function of the pseudorapidity and azimuthal angle difference, Δη and Δϕ respectively. These correlations are studied using the balance function that probes the charge creation time and the development of collectivity in the produced system. The dependence of the balance function on the event multiplicit
Background and aim Pain is common and adds to the global burden of disease. However, individuals suffering from pain are a heterogeneous group in terms of pain spreading, intensity and duration. While pain influences overall health care consultation not everyone with pain consult health care. To be able to provide health care matching the patients’ needs increased knowledge about what factors dete
Objective: Ovarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype with distinct clinical features, but may nonetheless be difficult to distinguish morphologically from other subtypes. There is limited knowledge of genetic events driving OCCC tumorigenesis beyond ARID1A, which is reportedly mutated in 30-50% of OCCCs. We aimed to further characterize OCCCs by combined global
The nucleotide sequence of a 2.7-kilobase segment of DNA containing the sdhA and sdhB genes encoding the flavoprotein (Fp, sdhA) and iron-sulfur protein (Ip, sdhB) subunits of the succinate dehydrogenase of Bacillus subtilis was determined. This sequence extends the previously reported sequence encoding the cytochrome b558 subunit (sdhC) and completes the sequence of the sdh operon, sdhCAB. The pr
Mammals are born with an immature gastrointestinal (GI) tract that allows the uptake of the specific nutrients and bioactive macromolecules in the milk, especially the protecting maternal antibodies. Eventually during weaning, the intake of milk decreases while that of solid food increases, and the GI system undergoes prominent structural and functional changes adapting the young this dietary chan
Previous research has found that moving objects bias heading perception only when they occlude the focus of expansion (FOE) in the background optic flow, with the direction of bias depending on whether the moving object was approached or at a fixed distance from the moving observer. However, the effect of object motion on heading perception was confounded with object position in previous studies.
Ellipsometry and radio-labelling techniques were employed to study the deposition of human serum albumin (HSA) followed by excess of mono- or polyclonal anti-HSA to methylated silicon. Adsorbed HSA, and [HSA-monoclonal anti-HSA] layers were rapidly removed by 0.1-0.5% SDS, but [HSA-polyclonal anti-HSA] layers were not. The results suggest that antigens and polyclonal antibodies crosslink on surfac
This article accounts for recent developments in corporate social responsibility, international trade and investment law, international human rights law, development aid, and the laws of home states reaching extraterritorially in order to advance a regulatory perspective on commerce and human rights. While these developments are remarkable, the analysis documents the prevalence of softer strategie
