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Fetal guinea-pig epiphyseal chondrocytes were cultured in monolayers and as aggregates in the presence of antimicrotubular agents. Colchicine and vinblastine caused a dissociation of the Golgi complex, in addition to the disappearance of microtubules. Synthesis and secretion of proteoglycans and collagen were studied using radioactive precursors. Colchicine inhibited the synthesis of proteoglycans

An important part of responsible business practices is compliance with the law. This article details what actually happens when the laws of the host country fail to ensure adequate protection. The focus here is on land dispossession and loss of livelihood in relation to a gold mine project in central Ghana. How is it that a well-known international company—Newmont—with its own corporate social res

This article analyses producer-consumer relations in social media marketing in the Swedish dairy industry. The article discusses how ideas of interspecies intimacy are publicly performed in an interactive process between the dairy industry producers and social media users. Two examples from the Swedish dairy industry were chosen for analysis, one Instagram account and one Facebook account. The ana

Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a B

This study focusses on the hydrogeology of Urema Graben, especially possible interactions between surface water and groundwater around Lake Urema, in Gorongosa National Park (GNP). Lake Urema is the only permanent water source for wildlife inside GNP, and there are concerns that it will disappear due to interferences in surface-water/groundwater interactions as a result of changes in the hydraulic

A major issue in Irish economic history is the lack of historical national accounts before the interwar period. This paper addresses the gap with new annual estimates of real GDP between 1842 and 1913 using an indirect estimation technique based on a set of macroeconomic variables and a dynamic factor model. Three major results emerge from the data. First, per capita growth was faster in this peri

Risks include the factors that might adversely affect project outcomes. Risk analysis includes the processes concerned with identifying, analyzing and developing security strategy and plans for the factors. Although currently there are known methodologies such as (CCTA Risk Analysis and Management Method (CRAMM) or Consultative, Objective and Bi-functional Risk Analysis(COBRA) and so on) for Risk

Purpose – There is growing concern about the performance of public organizations (POs) in developing countries. Despite the fact that the advantages of innovation and learning orientation to organizations have been evidently documented in Western economies and private owned enterprises, there has been little research into these practices and their impact on enhancing competitive advantages in POs

We use cosmological zoom-in simulations of galaxy formation in a Milky-Way-sized halo started from identical initial conditions to investigate the evolution of galaxy sizes, baryon fractions, morphologies, and angular momenta in runs with different parameters of the star formation-feedback cycle. Our fiducial model with a high local star formation efficiency, which results in efficient feedback, p

We calculate several differential distributions for exclusive double-diffractive χc(0++) production in the proton-antiproton collisions at the Tevatron and in proton-proton collisions at RHIC and LHC. We use unintegrated gluon distributions (UGDFs) within the kt-factorization approach. The g*g*→χc(0++) transition vertex is calculated as a function of gluon virtualities via the standard perturbativ

Recently observed Arctic greening trends from normalized difference vegetation index (NDVI) data suggest that shrub growth is increasing in response to increasing summer temperature. An increase in shrub cover is expected to decrease summer albedo and thus positively feed back to climate warming. However, it is unknown how albedo and NDVI are affected by shrub cover and inter-annual variations in

Thiosphaera pantotropha is capable of aerobic heterotropic nitrification and both aerobic and anaerobic denitrification. These phenomena have been studied in acetate-limited aerobic and anaerobic continous cultures supplied with ammonia and nitrate. The internal reaction rates were defined, based on biochemical knowledge. The observable external conversion rates are related through a linear equati

In this article, we study the effects of the 2004 terrorist bombings in Madrid on ethnic segregation in Spain. Using large-scale Spanish register data consisting of information on 5.4 million international migration events on a monthly basis and 13.9 million intermunicipal migration events, of which 3.8 million events concern the foreign-born population’s internal migration within Spain, the analy

Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the use of

Seasonal snow cover in mountainous regions will affect local climate and hydrology. In this study, we assessed the role of altitude in determining the relative importance of temperature and precipitation in snow cover variability in the Central Tianshan Mountains. The results show that: (a) in the study area, temperature has a greater influence on snow cover than precipitation during most of the t