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Neisseria meningitidis (meningococcus) is an important cause of meningitis and sepsis. Currently, there is no effective vaccine against serogroup B meningococcal infection. Host defense against neisseriae requires the complement system (C) as indicated by the fact that individuals deficient in properdin or late C components (C6-9) have an increased susceptibility to recurrent neisserial infections

Deficiency of complement components within the classical pathway is associated with increased risk for immune complex disease. However, C2-deficient individuals often have a mild disease and about 50% are healthy. To study the importance of the different components for immune complex clearance, bovine serum albumin (BSA)/anti-BSA complexes were opsonized in human serum and the binding to erythrocy

The adsorption of a single and negatively charged polyion with varying flexibility onto a surface carrying both negative and positive charges representing a charged membrane surface has been investigated by using a simple model employing Monte Carlo simulations. The polyion was represented by a sequence of negatively charged hard spheres connected with harmonic bonds. The charged surface groups we

In response to infection, epithelia mount an innate immune response that includes the production of antimicrobial peptides. However, the pathways that connect infection and inflammation with the induction of antimicrobial peptides in epithelia are not understood. We analyzed the molecular links between infection and the expression of three antimicrobial peptides of the beta-defensin family, human

Electronic factors influencing the photoluminescence properties and rates of excited state intramolecular proton transfer (ESIPT) reaction of o-hydroxy derivatives of 2,5-diphenyl-1,3,4-oxadiazole have been studied. The potential of these molecules as emissive and electron transport materials in designing improved organic light emitting diodes (OLEDs) has been studied by analyzing possible reasons

Fashion's universal nature does not preclude strong variations in its significance from society to society. As a stratification variable, fashion's importance increases in step with economic growth. Simmel sees the ‘need for distinction’ and the ‘need for union’ as preconditions for fashion, with certain societies lacking the necessary motivation. Variations in fashion's importance have also been

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This essay reflects on issues of contemporaneity and on the possibilities and limitations to pass judgment on the time you live in. The essay won first prize in HSFR's essay contest for young Ph.D. students in 1998.

Three kinds of light emission are taking place from organisms: bioluminescence in a narrow sense from some animals, dinoflagellatees, fungi and bacteria; delayed light emission from photosynthetic cells; ultraweak light emission from all kinds of cells. All these phenomena are treated in this chapter.

This paper discusses the concept of ‘precarious employment’ in relation to the Swedish shipbuilding industry in the 1960s and 1970s. In this setting, characterized by shortage of labour, a dual labour market structure emerged, where some workers were directly employed by the shipyards and others indirectly employed through intermediaries. The case differs from classical accounts of dual labour mar

Comparable country profile that describes the evolution and practice of corporate Sustainability and Responsibility (CSR) in Saudi Arabia.

Background: Patients with alcohol and other drug use disorders (AOD) frequently have multiple social, physical, and mental health treatment needs, yet have difficulty accessing community services, including drug abuse treatment. One strategy for linking patients with AOD with relevant services is case management, where a single case manager is responsible for linking patients with multiple relevan