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Popular Abstract in Swedish Denna avhandling är uppbyggd kring fyra artiklar som berör reglering av gener i B-celler. B-cellerna är en viktig del av vårt immunförsvar, de sköter produktionen av antikroppar som hjälper till att skydda våra slemhinnor och vårt inre från sjukdomsframkallande bakterier och virus. Kroppens försvar mot sådana patogener består av flera delar, inklusive vår hud och våra sEach Ig V-region has its own upstream promoter and the promoter of a mature Ig gene is thereby selected during the V(D)J recombination process. Upon comparison, it is evident that only one transcription factor binding site, the octamer, is preserved within all promoters. The octamer motif and the binding Oct-proteins are crucial for Ig promoter function, but not sufficient for a high level of tran

Moisture is decisive for a large number of reaction, binding and transport processes in concrete affecting the durability, shrinkage and performance in various environments. Consequently, the role of moisture must be assessed and quantified in a diagnosis of concrete degradation by moisture measurements and a survey of environmental actions. The paper gives an over-view of the role of moisture in

We performed high-resolution simulations of two stellar collisions relevant for stars in globular clusters. We considered one head-on collision and one off-axis collision between two 0.6-Msolar main-sequence stars. We show that a resolution of about 100000 particles is sufficient for most studies of the structure and evolution of blue stragglers. We demonstrate conclusively that collision products

In the module allocation problem a collection of software modules are to be assigned to physical processing nodes, subject to execution and communication cost. The cost of an allocation is a function of the execution costs and the communication costs for any pair of modules allocated to distinct processors. The module allocation problem has been well studied and is known to be NP-complete except f

Individuals with autism spectrum disorder (ASD) experience high levels of anxiety symptomatology with an estimated prevalence rate of anxiety disorders as high as 40 %. It is likely that anxiety is prominent in individuals with ASD throughout the life-span and that factors such as age, IQ, and ASD symptoms may influence the rates, symptoms, or anxiety subtypes. The high comorbidity rate of anxiety

In the West, everybody is now talking about the economic and financial crisis. The term ‘’crisis” has become a buzzword within both academic and policy communities. There is an enormous upsurge of scholarly interest in the effects of this crisis on public administration systems, and the role that public administration plays in these processes. The underlying belief is that the public administratio

The Mach number and pressure on the outlet plane of a straight micro-tube were investigated numerically for both laminar and turbulent flow cases. The numerical methodology is based on the Arbitrary-Lagrangian-Eulerian (ALE) method. The LB1 turbulence model was used for the turbulent flow case. The compressible momentum and energy equations with the assumption of the ideal gas were solved. The com

Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel

We present the results of multiple simulations of open clusters, modelling the dynamics of a population of brown dwarf members. We consider the effects of a large range of primordial binary populations, including the possibilities of having brown dwarf members contained within a binary system. We also examine the effects of various cluster diameters and masses. Our examination of a population of w

When Axel Oxenstierna, Chancellor of Sweden, died in 1654, Sweden was a great power. In 1612, however, when Oxenstierna took office, Sweden was on the verge of collapse. In the east, she was menaced by Muscovy, in the south-east by Poland, and in the west by Denmark. One of the means to save the Swedish realm was through active diplomacy. Two important figures in Oxenstierna’s diplomatic network w

We investigate whether the recently observed population of high-velocity white dwarfs can be derived from a population of binaries residing initially within the thin disc of the Galaxy. In particular, we consider binaries where the primary is sufficiently massive to explode as a Type II supernova. A large fraction of such binaries are broken up when the primary then explodes as a supernova, owing

Chronic obstructive pulmonary disease (COPD) is characterised by a chronic inflammation in conducting airways and the alveolar parenchyma. The inflammation, which is a consequence of inhalation of noxious gases like tobacco smoke, has traditionally been thought to be driven by innate immune responses. However, more recent studies have revealed an increase in lymphocyte-rich lymphoid aggregates (LA

New basis sets of the atomic natural orbital (ANO) type have been developed for the main group and rare gas atoms. The ANO's have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive and negative ions, and the dimer at its equilibrium geometry. Scalar relativistic effects are included through the use of a Douglas-Kroll Hamiltonian. Multico

The mechanism of templated synthesis of ordered mesoporous alumina according to the recipe proposed by Yada et al. (Yada, M.; Machida, M.; Kijima, T. Chem. Commun. 1996, 769) using sodium dodecyl sulfate (SDS) as template, has been investigated by NMR self-diffusion and spin and fluorescence probe techniques. In the precursor solutions urea was found to produce a substantial shortening of the long