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Wheat bran arabinoxylan can be converted by enzymatic hydrolysis into short arabinoxylo-oligosaccharides (AXOS) with prebiotic potential. Alkali extraction of arabinoxylan from wheat-bran offers advantages in terms of yield and results in arabinoxylan with highly-substituted regions which has been a challenge to hydrolyse using endoxylanases. We show that this hurdle can be overcome by selecting a

Objectives: To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin. Methods: Based on our findings during the 2017-2018 harvest (harvest 1), recommendations that enhanced the rest

Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcin

Although up to 30% of babies born with haemophilia do not have a family history of the disorder, the remaining 70% are born in families where haemophilia has been diagnosed. It has been estimated that for each male with haemophilia, there are five potential female carriers. Such women will benefit from knowledge of both their genetic (mutation present or not) and phenotype (level of plasma factor

Water loss is a crucial factor for vegetation in the semi-arid Sahel region of Africa. Global satellite-driven estimates of plant CO2 uptake (gross primary productivity, GPP) have been found to not accurately account for Sahelian conditions, particularly the impact of canopy water stress. Here, we identify the main biophysical limitations that induce canopy water stress in Sahelian vegetation and

How are public spaces regulated in tourist cities? In this doctoral dissertation I seek to answer this question by exploring the intersections between urban tourism and public space regulation. I argue that public space regulation substantially differs from the tourist to the non-tourist zone. This thesis contradicts the common belief that public space regulation may vary from city to city, but re

Transfusion only occasionally gives rise to antibody production, because blood cells per se are not markedly immunogenic. However, the immunological changes that occur during pregnancy increase the risk of alloimmunization against red blood cells, platelets, and/or leukocytes. Fetal-maternal bleeding during pregnancy or in relation to delivery is the antigenic stimuli for immunization against red

Indoor lighting is known to affect people’s wellbeing, mood and behaviour. The rapid development of new energy-efficient lamp technologies has enabled new lighting applications in home environments. To investigate the prospects of introducing a personalised light emitting diode (LED)-based home lighting technology, a mixed-methods research study was carried out, applying the goal-framing theory. T

Microbial decomposers are responsible for the breakdown of organic matter (OM) and thus regulate soil carbon (C) stocks. During the decomposition of OM, microorganisms can use the assimilated C for biomass production or respire it as CO2, and the fraction of growth to total assimilation defines the microbial carbon-use efficiency (CUE). As such, CUE has direct consequences for how microbial decomp

Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognosis of many cancers, few studies examined DNA methylation in EGLNs and its relationship to prognosis

The applicability of the Weibull distribution to model the strength of glass, the existence of a size effect on the strength and the need for a non-destructive testing of the strength are discussed and reviewed. There are a growing number of studies that put into question the applicability of the Weibull distribution to model annealed glass fracture data. A recent study indicates that the breakage

In search of a way to improve the nutritional profile of noodles, we prepared them with various mixtures of durum wheat flour and isolated plantain starch, and tested their proximal composition. Cooked noodles were assessed for in vitro starch digestibility, indigestible fraction content, and predicted glycemic index. The protein content declined with the addition of plantain starch. Both total st

To increase the added value of arracacha flour, a soup type food was designed considering the traditional culinary recipes of this root. The methodology applied for this purpose, allowed to obtain the baked flour, and also the characterization of the physicochemical, functional composition, and in vitro digestibility; as well as to propose some formulations varying the flour contents from 40 to 65

BACKGROUND: Corn tortillas containing 20% (w/w) amaranth flour (AF) were kept in cold storage and analysed after various times for chemical composition and in vitro starch digestibility, including predicted glycemic index. Comparison was made with traditional nixtamalised corn flour (NCF) tortillas. RESULTS: Lipid and protein contents were higher in mixed NCF/AF tortilla than in NCF tortilla. Avai

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and there are currently limited treatment options for these patients. The disease is characterized by a reduction in airflow due to chronic bronchitis, as well as airspace enlargement in the distal lung, resulting in a loss of surface area available for gas exchange. At end-stage disease, oxygen therapy an

Background Globally recommended measures for comprehensive tuberculosis (TB) infection control (IC) are inadequately practiced in most health care facilities in Ethiopia. The aim of this study was to assess the extent of implementation of TB IC measures before and after introducing a comprehensive technical support package in two regions of Ethiopia. Methods We used a quasi-experimental design, wh

Regular weight-bearing exercise, especially during the pre- or early peripubertal years, leads to substantial benefits in bone mass and skeletal structure, enhancing bone strength at loaded sites. However, few fragility fractures occur in young adulthood, and only if the exercise-induced skeletal benefits are retained into older age, a time when the incidence of fragility fractures rises exponenti