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We present Gene-Aware Variant INterpretation (GAVIN), a new method that accurately classifies variants for clinical diagnostic purposes. Classifications are based on gene-specific calibrations of allele frequencies from the ExAC database, likely variant impact using SnpEff, and estimated deleteriousness based on CADD scores for >3000 genes. In a benchmark on 18 clinical gene sets, we achieve a sen
Hjärtsvikt betecknar ett syndrom som innebär att hjärtat har otillräcklig förmåga att försörja kroppen med blod. Detta kan antingen bero på att hjärtat inte kan fyllas med eller stöta ut tillräckligt med mängd blod. Patienter med hjärtsvikt har i allmänhet hög dödlighet, detta trots att stora framsteg har gjorts avseende behandlingen av hjärtsvikt, speciellt sedan 1980-talet. Femårsöverlevnaden föIntroduction: Despite major advances, the incidence rate and mortality of heart failure (HF) remains high, with a five-year survival of approximately 50%. At the time of inception of this thesis the familial risks of HF, including the aspects of mortality, were largely underdetermined. This thesis is composed of four papers with the main aims as follows:To determine the risk of hospitalization of
Background: Survivors of childhood cancer are at increased risk for a wide range of late effects. However, no large population-based studies have included the whole range of somatic diagnoses including subgroup diagnoses and all main types of childhood cancers. Therefore, we aimed to provide the most detailed overview of the long-term risk of hospitalisation in survivors of childhood cancer. Metho
The parasitoid wasp Nasonia vitripennis is an emerging genetic model for functional analysis of DNA methylation. Here, we characterize genome-wide methylation at a base-pair resolution, and compare these results to gene expression across five developmental stages and to methylation patterns reported in other insects. An accurate assessment of DNA methylation across the genome is accomplished using
Pain, use of painkillers and alcohol are highly prevalent in the general population. Aims of the study were to describe differences in pain, alcohol consumption and use of painkillers among two 60 year old birth cohorts stratified by gender. Participants were recruited from the Skåne centre of The Swedish National study on Aging and Care, a multicentre, prospective, longitudinal study. The sample
Floral scent is a crucial trait for pollinator attraction. Yet only a handful of studies have estimated selection on scent in natural populations and no study has quantified the relative importance of pollinators and other agents of selection. In the fragrant orchid Gymnadenia conopsea, we used electroantennographic data to identify floral scent compounds detected by local pollinators and quantifi
The Scaled Agile Framework (SAFe) is a framework for scaling agile methods in large organizations. We have found several experience reports and white papers describing SAFe adoptions in different banks, which indicates that SAFe is being used in the banking industry. However, there is a lack of academic publications on the topic, the banking industry is missing in the scientific reports analyzing
Emerging technologies have increased the need for cybersecurity protection in web-based systems. This is especially true for drone systems, where any attack would threaten critical missions trying to save lives. In this study, the Remote Mission Control platform developed by Remote Aero is examined, the goal is identifying cybersecurity risks and proposing improvements to strengthen the system
Under de senaste åren har influencer marketing kommit att bli en av de vanligast förekommande och mest effektiva marknadsföringsmetoderna. Metoden går ut på att influencers, genom samarbeten eller på uppdrag av näringsidkare, publicerar innehåll som är ägnat att främja försäljningen av näringsidkarens produkter. På så vis kan marknadsförare, genom att utnyttja influencers relation till sin publik,In recent years, influencer marketing has become one of the most commonly used and effective marketing methods. The method involves influencers who, through collaborations or on behalf of businesses, publishes content intended to promote the sale of the business’s products. In this way, marketers can utilize the influencer’s relationship with their audience to reach a specific target group on a mo
Barnets bästa ska vara avgörande för alla frågor om vårdnad, boende och umgänge. Barnets åsikter är en viktig del i bedömningen och som regel får barn, om det inte bedöms som olämpligt, komma till tals. Det är dock långt ifrån självklart att deras åsikter faktiskt påverkar utgången. Ett barn som motsätter sig att träffa en förälder kan ändå få umgänge beslutat av domstol trots att umgänge enligt lThe best interests of the child should be decisive in all matters concerning custody, residence and visitation. The child’s views are an important part of this assessment, and children are generally given the opportunity to express their opinions, unless it is deemed inappropriate. However, it is far from certain that these opinions actually influence the outcome. Even if a child opposes visiting
As generative artificial intelligence (“AI”) rapidly transforms sectors, regulators are racing to keep pace with technologies that evolve faster than legal frameworks can adapt. These systems, powered by large language models or foundation models, are not only capable of generating human-like content but also demonstrate behaviors that shift depending on their data, deployment, and interaction con
Publications Archive - Page 34 of 43 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Pro
https://rwi.lu.se/publications/page/34/ - 2026-07-19
4th International Workshop on the Sharing Economy THE INTERNATIONAL INSTITUTE FOR INDUSTRIAL ENVIRONMENTAL ECONOMICS AT LUND UNIVERSITY LUND, SWEDEN, 15-16 JUNE 2017 Nomen Nescio, Titulus etc SPONSORS: THE INTERNATIONAL INSTITUTE FOR INDUSTRIAL ENVIRON- MENTAL ECONOMICS, AT LUND UNIVERSITY THE DEPARTMENT OF URBAN PLANNING AND ENVIRONMENT AT KTH, ROYAL INSTITUTE OF TECHNOLOGY 4th International Work
https://www.iiiee.lu.se/sites/iiiee.lu.se/files/4iwse_final_31_oct._2016.pdf - 2026-07-19
pnas201006568 11602..11607 Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors Rohit Sachdevaa, Marie E. Jönssona, Jenny Nelandera, Agnete Kirkebya, Carolina Guibentifa, Bernhard Gentnerb, Luigi Naldinib, Anders Björklunda, Malin Parmara, and Johan Jakobssona,1 aDepartment of Experimental Medical Sciences, Wallenberg Neuroscience Center,
https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/11602.full_.pdf - 2026-07-19
pnas201006568 1..6 Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors Rohit Sachdevaa, Marie E. Jönssona, Jenny Nelandera, Agnete Kirkebya, Carolina Guibentifa, Bernhard Gentnerb, Luigi Naldinib, Anders Björklunda, Malin Parmara, and Johan Jakobssona,1 aDepartment of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund Uni
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/sachdeva_et_al_pnas_2010.pdf - 2026-07-19
BACKGROUND BRIEF Key International Standards and Guidelines Relating to Displacement in the Context of Disasters and Climate Change Regional Asia Programme Report - Funded by Sida Title Written by Dr Matthew Scott* * Researcher and Team Leader, People on the Move thematic area, Raoul Wallenberg Institute of Human Rights and Humanitarian Law (www.rwi.lu.se) TABLE OF CONTENTS 1. Introduction 2. What
https://rwi.lu.se/app/uploads/2019/02/Background-Brief.pdf - 2026-07-19
Vägledning för oavlönad docentur 241204, eng Page 1 of 7 Date 2024-12-04 Reg no Styr 2024/2849 Guidelines for applications to be appointed as a Docent at the Faculty of Medicine, Lund University A person who has obtained a doctoral degree is eligible to apply for the post of Docent in a specific research and education area. For the Docent to be justified it needs to be deemed beneficial for the re
Programme syllabus Bachelor of Science Programme in Development Studies Faculty of Social Sciences SGUTV, Bachelor of Science Programme in Development Studies, 180 credits Kandidatprogram i utvecklingsstudier, 180 högskolepoäng First cycle degree programme not requiring previous university study / Program utan akademiska förkunskapskrav och med slutlig examen på grundnivå Decision The programme sy
https://www.keg.lu.se/en/sites/keg.lu.se.en/files/2024-01/SGUTV-programme-syllabus-2020%20(1).pdf - 2026-07-18
