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When conducting randomised clinical trials, the choice of methodology and statistical analyses will influence the results. If the planned methodology is not of optimal quality and predefined in detail, there is a risk of biased trial results and interpretation. Even though clinical trial methodology is already at a very high standard, there are many trials that deliver biased results due to the im

High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NENs) are highly aggressive cancers. The molecular etiology of these tumors remains unclear, and the prevalence of pathogenic germline variants in patients with HG-GEP NENs is unknown. We assessed sequencing data of 360 cancer genes in normal tissue from 240 patients with HG-GEP NENs; 198 patients with neuroendocrine carcinomas (

While never a numerically significant religion, the idea of Satanism is intimately intertwined with a number of broader issues relevant for the study of religion and culture. The notion of devil-worshipping cults has been a surprisingly stable element of conspiracy theories, historically as well as in the present, and accusations of being in league with demonic forces is a recurring motif in relig

Children with cancer experience recurring hospitalizations and isolation during treatment, which affect their school attendance. This study explores experiences of children with cancer, their classmates, and teachers with using the telepresence robot as a learning mediator in the hybrid classroom during treatment periods. 31 children with cancer (aged 7–17 years), 30 teachers, and 118 classmates p

Aims/hypothesis: The rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin secretion (GSIS), emphasising the role of beta cell dysfunction in the early stages of the disease. In search of novel mechanisms of beta cell dysfunction after long-term exposure to mild to severe glucotoxic conditions, we extensively characterise

Understanding wood surface moisture variations is fundamental to the modelling of moisture content. Exposure to sunlight, fluctuating temperature and rain leads to superficial deterioration and reduced surface hydrophobicity. Here, the effect of weathering was studied through monitoring the surface and global moisture content of axially matched pre-weathered and planed sets of specimens exposed ou

Purpose We determined the characteristics of Chinese men undergoing initial prostate biopsy and evaluated the relationship between prostate specific antigen levels and prostate cancer/high grade prostate cancer detection in a large Chinese multicenter cohort. Materials and Methods This retrospective study included 13,904 urology outpatients who had undergone biopsy for the indications of prostate

The molecular composition of the organic and inorganic matrices of bone undergoes alterations during maturation. The aim of this study was to compare Fourier transform infrared (FT-IR) and near-infrared (NIR) Raman microspectroscopy techniques for characterization of the composition of growing and developing bone from young to skeletally mature rabbits. Moreover, the specificity and differences of

In this paper an approach for employing risk and vulnerability analyses as the basis for emergency preparedness planning is discussed and exemplified using a case study. The study consisted of three connected parts: a broad scope hazard identification and analysis, an assessment of potential assistance needs should any of the hazards materialise and finally a mapping of actors and dependencies. Th

The stake holders seem to be pending on each others reaction towards ISA-systems (Intelligent Speed Adaptation). A situation can occur in which the car owners do not invest in the system because the car industry do not believe in it, the car industry waits upon the politicians’ standpoint, and the politicians leer at the public opinion… Decision makers need a good picture of what decisions are nee

Purpose – In the last decade, greater attention has been paid to the role of management accounting and control (MAC) in making professional organizations more horizontal. The authors argue that earlier research has not shown how the interrelatedness between professional identities and MAC influences attempts to make organizations more horizontal. In this paper the authors respond to the call for m

Responding to increasing concerns with the quality of care in both Sweden and England, this paper explores the way in which caring practice emerges out of the interplay between personal and social agency. Working from a socio-cultural perspective, results from an English and a Swedish study conducted independently of each other were used to explore the construction of caring practice. The English

Our hypothesis was that carbohydrate, fat, and protein contents of meals affect satiety, glucose homeostasis, and hormone secretion. The objectives of this crossover trial were to examine satiety, glycemic-insulinemic response, and plasma peptide levels in response to 2 different recommended diabetes diets with equivalent energy content. One traditional reference breakfast and one test breakfast,

In this paper I study the public debt dynamics of three episodes (the crises of the 1950s, the 1980s and 2010-15) in Ireland’s modern economic history. By using traditional debt dynamic decomposition formulae, I measure the components which contributed most to public debt ratio reduction following previous high debt episodes. I also employ the case of Sweden for comparative purposes, in how it eme

Social scientists studying mental health from a qualitative approach faces a complex and diverse field. As an empirical field, the object in focus is usually summed up as being concerned with for example, experiences of a psychosis, enactments of the clinician-patient dialectic, or different encounters within, as well as outside, psychiatry. This paper is a suggestion for how to approach and use t

Critical infrastructures provide essential services for the functioning of the society, and vulnerability analysis is an important basis for decisions concerning increasing their robustness against strains. Since critical infrastructures can be regarded as complex systems, such analyses can prove challenging. To analyze the system response to strains, several different functional models have been

The need for red blood cells to transport oxygen and CO2, blood platelets to stop bleedings, and neutrophils, macrophages, B- and T-cells for host defense, is a prerequisite for life. These mature blood cells have a limited life span and are thus constantly replenished by an enormous cell production (estimated to 1012 cells per day) which primarily takes place in the bone marrow (BM). Mature blood

The aim of this article is to analyze reported changes in outdoor mobility, increased/unchanged/decreased, for a sample of older people (>62 years) in two regions in Sweden, who have transitioned from a two-person to a single-person household during the two years since the study was conducted. The target group (N=162) consists of all people who had transitioned to a single-person household in a ra

Many modern software applications have performance requirements, like mobile and embedded systems that must keep up with sensor data, or web services that must return results to users within an acceptable latency bound. For such applications, the goal is not to run as fast as possible, but to meet their performance requirements with minimal resource usage, the key resource in most systems being en