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Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
Background: Sleep problems (insomnia) and chronic pain are associated. Chronic pain and insomnia/insufficient sleep quality share similar symptoms and features. Although they have a bidirectional relationship, more research is needed to understand how they interact via mediators and how moderators influence this relationship. Aims: In this large clinical registry-based cohort study (N = 6,497), we
Community-acquired pneumonia (CAP) is a significant health threat for adults. Although conjugate vaccines have reduced pneumococcal CAP incidence in children, Streptococcus pneumoniae-related CAP remains prevalent among older adults. The nasopharynx acts as a reservoir for S. pneumoniae, yet the interplay between this pathogen and the nasopharyngeal microbiome during and after pneumonia remains po
BackgroundAs primary health care forms the basis of the health care system, it is regarded as an efficient way to address main causes of, and risk factors for, poor health. In the Swedish health care system, general practitioners play a role in facilitating access to specialized health care and in coordinating care from other parts of the health care system. In Sweden, recent marketization efforts
Aims: Data on sex and left ventricular assist device (LVAD) utilization and outcomes have been conflicting and mostly confined to US studies incorporating older devices. This study aimed to investigate sex-related differences in LVAD utilization and outcomes in a contemporary European LVAD cohort. Methods and results: This analysis is part of the multicentre PCHF-VAD registry studying continuous-f
The growing digitalization of recent decades and the ease with which we can connect to others on the web has resulted in many forms of civil activism which appear hardly conceivable without it. Ironically, one of the most profound of these manifestations has been in its defense. In 2012, a European public went online and took to the streets to demonstrate, ultimately successfully, against the Anti
This report summarises the results of a thesis work performed at Lund University, Faculty of Engineering (LTH) in association with Volvo Car Corporation (VCC) in the autumn of 2010 through the winter of 2011. The task is to develop a system to mount a bright trim on a vehicles bodyside. A bright trim is a polished metal trim that is fitted around the windows of a vehicle for aesthetical reasons. T
Background Manufacturing companies often have to balance the use of components for manufacturing and for aftermarket sales. This puts pressure on these companies to efficiently organize and prioritize their needs and supply of these. The Gasketed Plate Heat Exchanger Business Unit within Alfa Laval is an example of a company experiencing this type of need. The business unit has two separate parts,
Denna uppsats undersöker räckvidden av tillämpningsområdet av principen non-refoulement för personer som tvingas migrera på grund av klimatförändringar, genom rättighetskatalogerna ICCPR och EKMR. Ämnet är av stor betydelse eftersom effekterna av klimatförändringarna är beräknade att innebära en tvångsförflyttning av över en miljard människor innan år 2050. Frågan gällande vad dessa personer har fThis thesis examines the scope of non-refoulement under the international human rights instruments ICCPR and ECHR, in cases of climate displacement. This topic is important, as the effects of climate change are predicted to trigger a mass population displacement of over one billion people by the year 2050. This raises the issue of international protection for climate displaced persons, which will
Friskrivningsklausuler är vanligt förekommande i kommersiella avtal och fungerar som en avtalad riskfördelning mellan parterna. Rätten att använda friskrivningsklausuler följer av principen om avtalsfrihet. Genom att upprätta friskrivningsklausuler kan parterna frångå de dispositiva regler som gäller för avtalsförhållandet. Förekomsten av det stränga konsultansvaret för konsulter medför att en konDisclaimers are common in commercial contracts and act as contractual allocation of risks between the contracting parties. The right to use disclaimers originates from the principle of freedom of contract. Parties may, by establishing disclaimers, deviate from optional law otherwise applicable on the contractual relationship. The strict consultant responsibility entails that a consultant is genera
In this thesis a framework for finding anomalies in streaming data is proposed. The framework proposed is not necessarily applicable only to problems in anomaly detection, but could be applied to other problems as well. There are three main concepts at play in the framework: (i) Active Learning, a learning algorithm which can query a human specialist for labels of instance such that the model can
This work analyzed the impact caused by different intensities of Pulsed Electric Fields (PEF) pre-treatment on the biogas production from small-scale anaerobic digesters of wastewater sludge under thermophilic conditions. PEF technology consists of passing the substrate through an electric field which generates a potential difference across the cells, resulting in electroporation. Mixed sludge fro
Eftersom människan nu står inför sin största utmaning någonsin – klimatkrisen – är det viktigare än någonsin att miljöskyddet integreras i alla delar av den Europeiska unionen. Miljöskydd anses vara ett huvudmål för EU. I Artikel 3.3 i EU-fördraget anges att Unionens inre marknad bör arbeta för en hållbar utveckling och en hög skyddsnivå och förbättring av miljön. Den inre marknaden ska dock ocksåAs humanity is facing its biggest challenge ever – the climate crisis – it is now more important than ever that environmental protection is integrated in all parts of the European Union. Environmental protection is considered a main objective of the EU. In Article 3(3) of the TEU is stated that the internal market of the Union should work for a sustainable development and a high level of protectio
Den 1 juli 2018 trädde det som brukar kallas för samtyckeslagen ikraft i Sve-rige. Sexualbrotten våldtäkt och sexuellt övergrepp är därmed numera kon-struerade med frivillighet som grundrekvisit. Skyddsintressena för lagstift-ningen är den enskildes sexuella självbestämmande och sexuella integritet. I 6 kap. 1 § brottsbalken stadgas att den som med en person som inte deltar frivilligt, genomför eIn 2018 Sweden passed a new sexual offence legislation based on consent. The new law came in effect on 1 July. Due to the new law, the lack of consent is now enough to constitute a sexual offence. The sexual offences affected by the new law are rape, 6 kap. 1 § brottsbalken, and sexual abuse 6 kap. 2 § brottsbalken. The interests protected by the sexual offence legislation are the right to self-de
Listeria monocytogenes is a pathogen, sometimes occurring in fresh cheese, such as Queso Fresco. Antimicrobials could be utilized to prevent the presence of L. monocytogenes in this type of cheese. In order to be able to screen and assess several novel antimicrobials simultaneously in the future, the validated miniaturized laboratory-scale model for Queso Fresco (MLQF) was further developed into a
Background and Objectives: This project explored the needs of art galleries and collectors for Digital Asset Management Systems (DAMS), in order to fill an existing knowledge gap and help companies to analyse these needs. Bespoken difficulties in the field significantly challenge the development of DAMS and have thus also hampered the evolvement of high-quality systems for the art market. There se
The aim of this thesis is to by studies and analyses of the past, in this case an older real-catalog system used during the period 1930-1960 at the Folklore archive in Lund, learn and create understandings for the system used at the archive from 1991 to today, which is a text database system. By this create understandings of how an organisations history can affect and influence the present, and wi
In this master´s dissertation I investigated if it is possible to increase the total stability for excavations in clay, if suction is taken into account during the calculations. The work has been performed at, and in cooperation with, Sweco Civil AB as well as the Dept. of Construction Sciences at Faculty of Engineering LTH, Lund University. The objective of this master´s dissertation is to asse
In the State of Oaxaca in Southern Mexico exist abundant natural resource and excellent wind conditions. Currently in the region of the Isthmus of Tehuantepec in Oaxaca has an extensive area with wind farm projects due to their excellent wind speed conditions. A large wind energy plant – the Project Mareña Renovables that since their origins started in 2004 with Preneal Company. It was planned to
This deliverable reports on Risk Assessment for Wetland Sediment Applications on Agricultural Land. The main content is a thorough and critical evaluation (literature review) of the wetland coupled agriculture and the related concerns such as nutrients, sediments and contamination risks. This will also be supported by the two case studies. Constructed wetlands act as traps for substances carried w
