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Activated Lactococcus lactis beta-phosphoglucomutase (beta PGM) catalyzes the conversion of beta-D-glucose 1-phosphate (beta G1P) derived from maltose to beta-D-glucose 6-phosphate (G6P). Activation requires Mg2+ binding and phosphorylation of the active site residue Asp8. Initial velocity techniques were used to define the steady-state kinetic constants k(cat) = 177 +/- 9 s(-1), K-m = 49 +/- 4 mu
PURPOSE: To investigate whether separate physical tests of the lower extremities, that assess movement speed and postural control, were associated with cognitive impairment in older community-dwelling subjects. SUBJECTS AND METHODS: In this population-based, cross-sectional, cohort study, the following items were assessed: walking speed, walking 2 × 15 m, Timed Up and Go (TUG) at self-selected an
Carlsson M, Heiberg E, Toger J, Arheden H. Quantification of left and right ventricular kinetic energy using four-dimensional intracardiac magnetic resonance imaging flow measurements. Am J Physiol Heart Circ Physiol 302: H893-H900, 2012. First published December 16, 2011; doi: 10.1152/ajpheart. 00942.2011.-We aimed to quantify kinetic energy (KE) during the entire cardiac cycle of the left ventri
The Ukrainian Shield comprises the exposed crust of the large Palaeoproterozoic protocraton Volgo-Sarmatia, which together with the Fennoscandian crustal segment constitutes the East European Craton ("Baltica"). Geological and geophysical data indicate that 1.80 to 1.75 Ga mafic dykes related to anorthosite-mangerite-charnockite-granite (AMCG) plutons are widespread within the Ukrainian Shield. We
Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast canc
Background: Orthostatic hypercoagulability is proposed as a mechanism promoting cardiovascular and thromboembolic events after awakening and during prolonged orthostasis. We evaluated early changes in coagulation biomarkers induced by tilt testing among patients investigated for suspected syncope, aiming to test the hypothesis that orthostatic challenge evokes procoagulatory changes to a different
Changes to the contemporary food system, including meals and eating patterns, have occurred quickly. One such change over the past 30 years has been the increase of commercially produced foods aimed at food allergies and intolerances and ‘free from’ dieting. The gluten free diet has recently emerged as a popular diet trend in Western countries, outpacing its origins as a treatment for celiac disea
Resultaten i denna avhandling ökar vår kunskap om hur evolutionen av feromondetektering hos fjärilar gått till.Luktsinnet är viktigt för de flesta djur, inklusive människor, hundar, insekter och många andra. Hos insekter, särskilt nattfjärilar och flugor, används luktsinnet för att hitta parningspartners, föda, äggläggningsställen och att undkomma fiender.Feromoner är kemikalier som produceras ochIn moths, females produce sex pheromone compounds to attract males over a long distance for mating. The antennae of moths and many other insects have specialized odorant receptors (ORs), called pheromone receptors (PRs), to sense the pheromone compounds and they group in a monophyletic clade (PR clade).In this thesis, I investigated and compared various components of the olfactory system in differ
Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mineral density and increased fracture risk. Although the genetic basis of osteoporosis is incompletely understood, previous studies have identified a polymorphism affecting an Sp1 binding site in the COLIA1 gene that predicts bone mineral density and osteoporotic fractures in several populations. Here
This paper presents the light-scattering properties of atmospheric aerosol particles measured over the past decade at 28 ACTRIS observatories, which are located mainly in Europe. The data include particle light scattering (σsp) and hemispheric backscattering (σbsp) coefficients, scattering Ångström exponent (SAE), backscatter fraction (BF) and asymmetry parameter (g). An increasing gradient of σsp
Background: Child marriage is being increasingly recognized globally as a fundamental violation of human rights. Child marriages occur globally in varying degrees across countries and regions. South Asia alone accounted for almost half of the total number of child marriages that have occurred globally. Early marriage can lead to serious ramifications such as school drop-out, early pregnancy, mater
Background: Alkaline enzymes are stable biocatalysts with potential applications in industrial technologies that offer high quality products. Objective: The growing demand for alkaline enzymes in industry has enhanced the search for microorganisms that produce these enzymes. Methods: Eighteen bacterial isolates from Lake Bogoria, Kenya, were screened for alkaline proteases, pectinases and amylases
Long-term stability of endosseous implants depends on successful bone formation, ingrowth and adaptation to the implant. Specifically, it will define the mechanical properties of the newly formed bone-implant interface. 3D imaging during mechanical loading tests (in situ loading) can improve the understanding of the local processes leading to bone damage and failure. In this study, titanium screws
The present global environmental condition is a consequence of the increasing consumption of natural resources whose depletion exceeds what is physically possible to sustain in the long term. The construction sector is a considerable contributor to this resource depletion and sustainability is adopted in the form of the theory of ecological modernization. The implementation depends to varying exte
Popular Abstract in Swedish Däggdjurens mag-tarmkanal genomgår dramatiska strukturella och funktionella förändringar under di-perioden för att anpassa individen för den fasta föda som kommer att bli den huvudsakliga näringskällan efter avvänjningen från modersmjölken. Dessa förändringar följer en ?biologiska klocka? och är således huvudsakligen genetiskt styrda. Däremot kan yttre och inre stimuli The timing of the postnatal development of the gastrointestinal (GI) tract in mammals is influenced by dietary and hormonal factors. It was hypothesized that accelerated GI cell turnover during maturation would result in a precoucios conversion to more mature digestive functions. Thus, it was investigated if red kidney bean lectin, phytohaemagglutinin (PHA) - a potent gut mitogen in adult rats - c
Popular Abstract in Swedish Luften omkring oss består inte bara av gaser. I den finns det mängder av små partiklar. De partiklar som står i fokus i den här avhandlingen är mindre än 10 μm, vilket endast är en femtedel av ett hårstrås diameter. Dessa partiklar är tillräckligt små för att kunna förflyttas långa sträckor i atmosfären och har dessutom visat sig påverka människors hälsa negativt. Man hAerosol particles are found in the whole troposphere. Research regarding these particles has gained increased attention because of the effect the particles have on both health and climate. In the atmosphere, aerosol particles scatter incoming solar radiation and this has a cooling effect on the Earth’s climate. But there are particles, especially those containing soot, which can absorb sun light a
Background: Except for overall survival, whether or not waiting time for treatment could influences other domains of cancer patients' overall well-being is to a large extent unknown. Therefore, we performed this study to determine the effect of waiting time for cancer treatment on the mental health of patients with esophageal or gastric cancer. Methods: Based on the Swedish National Quality Regist
Popular Abstract in Swedish Hjärt-kärlsjukdom är den vanligaste dödsorsaken i västvärlden. Till gruppen hjärt-kärlsjukdom räknas t.ex. hjärtinfarkt, åderförkalkning, högt blodtryck, kärlkramp och hjärtsvikt. Gemensamt för dessa sjukdomar är att blodkärlens egenskaper förändras. Blodkärlen drar lättare ihop sig vilket försämrar blodflödet och därmed sjukdomstillståndet. En orsak till förändringarnaAngiotensin II (Ang II) and endothelin-1 (ET-1) induce strong vasoconstriction via activation of receptors on vascular smooth muscle cells. In this thesis, the contractile Ang II and endothelin receptors were examined in endothelium-denuded human coronary arteries and in bypass grafts (the left internal mammary artery and the saphenous vein), with focus on receptor alterations in cardiovascular di
Popular Abstract in Swedish I det här arbetet har vattenlösningar av cellulosabaserade polymerer studerats. En polymer är en lång molekyl som består av många sammanlänkande repeterande enheter. Längs den vattenlösliga polymerryggraden har korta hydrofoba (vattenskyende) kedjor ympats, vilket resulterar i så kallade ympsampolymerer. I vattenlösning bildas ett polymernätverk genom att de hydrofoba gThe properties of hydrophobically modified cellulose derivatives in aqueous mixtures with various other molecules have been investigated. Mixtures of a hydrophobically modified polymer and alkali-sensitive, degradable surfactants gave rise to time-dependent viscosities. With time, the viscosity decreased continuously or went through a maximum, depending on the initial surfactant concentration. Th
Background: Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer cells with concomitant increase in 'inhibitor of differentiation 1' (ID1) gene expression. I
