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Inhibition of dipeptidyl peptidase- 4 ( DPP- 4) is currently being explored as a new approach to the treatment of type 2 diabetes. This concept has emerged from the powerful and rapid action of the enzyme to inactivate glucagon- like peptide-1 ( GLP- 1). However, other bioactive peptides with potential influence of islet function are also substrates of DPP- 4. Whether this inactivation may add to
OBJECTIVE: To adapt the Knee injury and Osteoarthritis Outcome Score (KOOS) into French and to evaluate the psychometric properties of this new version. METHODS: The French version of the KOOS was developed according to cross-cultural guidelines by using the "translation-back translation" method to ensure content validity. KOOS data were then obtained in patients with symptomatic knee osteoarthrit
BACKGROUND: There is conflicting evidence that traffic-related air pollution is a risk factor for allergic conditions. Few studies have investigated this in adults. In adults, a high proportion of asthma, rhinitis and eczema is triggered by non-allergic factors. We investigated traffic as a risk factor for allergic versus non-allergic asthma and rhinitis, and eczema, in adults. A questionnaire fro
Aim: Several studies have addressed the association between changes in the female sex hormones estrogen and progesterone levels and changes in parameters of periodontitis. In order to understand how these hormones affect periodontal health it is of major importance to obtain information on their physiological importance. We have previously shown that periodontal ligament cells (PDL cells) express
Popular Abstract in Swedish Mer än 75 % av energianvändningen i världen kommer idag från förbränning av fossila bränslen, biobränslen och avfall. Trots att alternativa energikällor är på framfart kommer förbränning stå för den största andelen av världens energianvändning även de kommande decennierna. Tyvärr medför förbränning flera negativa konsekvenser, såsom ökad koldioxidhalt i atmosfären och uLaser-induced incandescence, LII, is a laser-diagnostic technique that can be used to measure the volume fraction and the sizes of soot particles suspended in a gas, such as within a combustion process or in its exhausts. The technique is based on the facts that the time-decay of the radiation from laser-heated soot particles is directly related to the particle size in the probed volume, and that
Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets. Further, we studied islet apelin regulation and the effect of apelin on insulin secretion. Apelin expression and regulatio
Aim. To study nurses' compliance to national guidelines (Sweden) for peripheral venous catheters and to establish the complication frequency connected to time in situ and bore size. Background. Worldwide, there are no standard peripheral venous catheters guidelines, and the need for elective replacement has been challenged. Furthermore, the time interval and need for elective change of peripheral
Popular Abstract in Swedish Vårt behov av att öka matproduktionen för en växande global befolkning, har sedan mitten av nittonhundratalet drivit jordbrukets utveckling. Det traditionella, småskaliga jordbrukslandskapet med sitt lapptäcke av betesmarker, ängar och åkrar, har över tid ersatts av ett mer produktionsinriktat landskap. Åkrar har slagits ihop för att skapa större odlingsenheter, där nyaThe intensification of agriculture during the second half of the twentieth century, has caused sever declines of farmland biodiversity, where loss of semi-natural habitats is one of the major drivers. To halt further loss of habitat and biodiversity, agri-environmental schemes (AES) are used to compensate farmers to use methods less harmful to the environment. In this thesis, I have investigated t
The possibility of using radio over fiber (RoF) analog transmissions to characterize the wireless propagation channel of distributed antenna systems is investigated. In particular, the coherence time of kilometer-long, fiber-based networks is analyzed. Joint measurements of the phase noise of parallel links to the same site (intra-site) and to different sites (inter-site) in such a network are pre
A significant portion of the large amount of carbon (C) currently stored in soils of the permafrost region in the Northern Hemisphere has the potential to be emitted as the greenhouse gases CO2 and CH4 under a warmer climate. In this study we evaluated the variability in the sensitivity of permafrost and C in recent decades among land surface model simulations over the permafrost region between 19
Background: As more people reach older age, there is a growing interest in improving old person's health, activity, independence and social participation, thereby adding quality to the extended years. Preventive home visits (PHV) programs for old people have received much attention in recent decades. A large body of research shows mixed effects, and argues that a home visit is a complex social pro
Although the U-Pb zircon chronometer has been widely used for dating metamorphism in moderate to high-grade rocks, it is generally difficult to link the U-Pb age of zircon to specific metamorphic reactions. In this study, the initial Hf isotopic composition of secondary zircon is compared with the evolution of Hf isotopic composition of the bulk sample, back-projected from the measured value throu
Background: Misuse of substances is a major contributor to disability and mortality worldwide. The use of tobacco, alcohol, and illegal drugs in adolescence and young adulthood are well-known risk factors for subsequent substance-related harms. A better understanding of adolescent and young adult substance use behaviors and their correlates might help develop new prevention programs. This thesis a
Background Clinical classification of rare sequence changes identified in the breast cancer susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of individuals carrying these variants. We previously showed that variant BRCA1 c.5096G>A p.Arg1699Gln in the BRCA1 transcriptional transactivation domain demonstrated equivocal results from a series of functional assays,
Background: Mechanical ventilatory support seriously affects speaking and communication, and earlier studies show that many ventilator-supported patients experience difficulties and frustration with their speech and voice production. Since there is a growing number of individuals who require mechanical ventilatory support and there is a paucity of studies that examine ventilator-supported communic
A larger study surrounding innovation capital has taken place at Lund University in Sweden. The purpose of the study was to examine what meaning the management, research department and the financial analysts perceive in the reported information about innovation capital. The authors have found some prominent patterns that arose during the interviews. The different perspectives between the research
This master thesis work comprises 20 academic credits (20 weeks) and was carried out in a time period beginning autumn 2004 ending early 2005 at the department of Industrial Management and Logistics under the division of Production Management at Lund Institute of Technology (LTH) in cooperation with IdeonCenter AB. The problem being investigated was how to measure the development of the new techno
Populärvetenskaplig sammanfattning: Supernovor och andra galaktiska system skickar ut mängder av atomkärnor med nära ljusets hastighet, så kallad kosmisk strålning. Eftersom supernovor framförallt finns i spiralarmarna i vår galax och jorden över långa tidsperioder rör sig relativt spiralarmarna så har det föreslagits att kosmisk strålning inte varit konstant under jordens historia. Vidare har visIt has been suggested that the cosmic ray flux varies as Earth moves relative to the spiral arms in the galaxy. However, no satisfying record over the cosmic ray flux over long time scales has been presented. This work aims to investigate the possibility to use cosmic ray tracks in silicate mineral inclusions in sediment-dispersed extraterrestrial chromite (SEC) grains as such a record. Chromite i
The myth of the user - a study of the user discourse and its visionaries This study is a discourse analysis of the visions that implicitly are expressed in different texts about user-centered library theory. Several other studies have analyzed the discourse and conceptualization of how the user is expressed in the library debate. Therefore we have chosen to analyze the visions that are expressed
