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Bone mineral density (BMD) is an established measure used to diagnose patients with osteoporosis. In clinical trials, change in BMD has been shown to provide a reliable estimate of fracture risk reduction, and achieved BMD T-score has been shown to reflect the near-term risk of fracture. We aimed to test the association between BMD T-score and fracture risk in patients treated for osteoporosis in

Objectives: The primary aim was to examine how event-related potentials (ERPs) and mismatch negativity (MMN) change and develop over time among children with hearing loss (HL) using hearing aids (HAs) or cochlear implants (CIs). Children with normal hearing (NH) were tested as a reference group. Methods: This three-year follow-up study included 13 children with sensorineural HL (SNHL); 7 children

Buildings account for a signifi cant proportion of the energy use thatgenerates greenhouse gases and consequently drives the ongoing climatechange. As the population of the world increases, the need for buildingsincreases, while the energy use needs to decrease. A reduction in energyuse and increased use of renewable energy are important measures forclimate change mitigation. A fi rst step in decr

Changes to the contemporary food system, including meals and eating patterns, have occurred quickly. One such change over the past 30 years has been the increase of commercially produced foods aimed at food allergies and intolerances and ‘free from’ dieting. The gluten free diet has recently emerged as a popular diet trend in Western countries, outpacing its origins as a treatment for celiac disea

Background: Orthostatic hypercoagulability is proposed as a mechanism promoting cardiovascular and thromboembolic events after awakening and during prolonged orthostasis. We evaluated early changes in coagulation biomarkers induced by tilt testing among patients investigated for suspected syncope, aiming to test the hypothesis that orthostatic challenge evokes procoagulatory changes to a different

The content of this thesis consists of two parts. For the first part, size and crystallographic orientational influence on the elastic properties of bcc nanowires and films have been studied through static molecular simulations. In order to explicitly account for surface effects, the concept of surface free energy has been employed. Comparisons between continuum mechanical calculations and results

This thesis explored the protective effects of growth factors and antioxidants on striatal and nigral neurons in in vitro and in vivo brain insult models and neural transplants. Five different growth factors were examined for their survival-promoting effects on cultured striatal neurons: basic fibroblast growth factor (bFGF), truncated insulin-like growth factor-1 (tIGF-1), platelet derived growth

Popular Abstract in Swedish Fetma, övervikt och allergi är ett problem i många delar av världen och förändringar i tarmens bakterieflora kan vara en av flera orsaker. Människan har tio gånger fler mikroorganismer än mänskliga celler. Flest mikroorganismer finns i tarmen och de brukar gemensamt kallas för tarmfloran. Många bakterier är helt oskadliga och en del är dessutom nödvändiga för att vi tilThe gastrointestinal tract of the foetus is considered sterile but during vaginal birth the neonate comes into contact with bacteria from the maternal vaginal and intestinal microbiota. The main focus of this doctoral thesis was to elucidate the initial bacterial ecosystem in newborns and to relate microbial perturbations to physiological traits. The bacterial flora was mainly studied with molecul

Objective Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3′ UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast canc

Selective removal of the basal forebrain cholinergic neurons by the immunotoxin 192 immunoglobulin G-saporin has offered a new powerful tool for the study of the relationships between cholinergic dysfunction and cognitive impairments. In the present study the morphological and functional consequences of selective lesions of the basal forebrain cholinergic system during early postnatal development

The script we are presenting below is one of four different scenarios from Violence & Learning by Henrik Bromander and John Hanse, which was performed at the International Brecht Society’s Symposium in Oxford in June 2016. The learning play Violence & Learning has been developed and performed in the context of left-wing activism in Sweden. The different variants of the play have partly bee

The workshop will focus on what first-year students to higher education needs to be successful and how a peer learning programme might address those needs. (~5 min for introduction)The workshop will start with a brainstorm session where participants in small groups will share thoughts and ideas on the question (~20 min for activity): “What would you like to affect with your new students? Provide s

Importance: Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective: To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. Design, Setting, and Participants: This mendelian randomization study used

Glutathione (GSH) is an endogenous antioxidant implicated in numerous biological processes, including those associated with multiple sclerosis, aging, and cancer. Spectral editing techniques have greatly facilitated the acquisition of glutathione signal in living humans via proton magnetic resonance spectroscopy, but signal quantification at 7 Tesla is still hampered by uncertainty about the gluta

Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA a

Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mineral density and increased fracture risk. Although the genetic basis of osteoporosis is incompletely understood, previous studies have identified a polymorphism affecting an Sp1 binding site in the COLIA1 gene that predicts bone mineral density and osteoporotic fractures in several populations. Here

Objective: To estimate intra- and interrater agreement and reliability with regard to describing ultrasound images of the endometrium using the International Endometrial Tumor Analysis (IETA) terminology. Methods: Four expert and four non-expert raters assessed videoclips of transvaginal ultrasound examinations of the endometrium obtained from 99 women with postmenopausal bleeding and sonographic

Three-dimensional (3D) models are widely used within the geosciences to provide scientists with conceptual and quantitative models of the earth’s subsurface. As a result, 3D geologic modelling is a growing field, such that scientific research often cannot keep up with technical advancements. Literature often shows conflicting results with respect to which interpolation algorithms produce the best

I uppsatsen berörs frågeställningen om hur värdeersättning beräknas när en sakskada har inträffat, när egendom har skadats genom en annan persons handling. Värderingen utgår från den skadeståndsrättsliga bestämmelsen i 5:7 1 p. Skadeståndslagen (SFS 1972:207, nedan benämnd SkL). Uppsatsens kärna består av en presentation och en diskussion om vilken värderingsmetod som är tillämplig vid totalskada This essay deals with the question of how damages on personal property is to be calculated when a damage has occured. It is assumed in this essay that the personal property has been damaged by another person's action. The calculation of the indemnity is based on 5:7 1 p. SkL. The essay presents which method of valuation that is applicable when the damage has taken place, and how the detriment

Uganda has experienced extreme weather for example droughts and flooding for many years resulting from rainfall deficits and variability. With the increased manifestation of negative effects related to climate change and global warming, this challenge is becoming greater and greater. And with increased public awareness about disasters and disaster risks, communities are ceasing to portray droughts