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Objective: In March 2018, the Explorer study, an international, double-blind, randomised controlled trial (RCT), established that adding a TLC-NOSF (UrgoStart Contact, Laboratoires Urgo, France) dressing to good local standard of care (SoC) significantly and substantially increases wound closure and reduces the healing time of neuroischaemic diabetic foot ulcers (DFU). Besides the TLCNOSF treatmen

AbstractBlind, I. 2015. Essays on Urban Economics. Economic studies 153. xii+199 pp. Uppsala:Department of Economics. ISBN 978-91-85519-60-6.This thesis consists of four self-contained essays.Essay 1 (with Olof Åslund and Matz Dahlberg): In this essay we investigate the impact ofcommuter train access on individual labor market outcomes. Our study considers the exogenousintroduction of a commuter t

Resandet med tåg har ökat stadigt i Sverige de senaste 30 åren. Takten har varit cirka två-tre procent per år, och vi nu har mer än dubbelt så många resenärer. Med ökat fokus på klimatfrågan stiger resandet nu ännu snabbare. Ett problem som drabbar både resenärer och företag i Sverige är tågförseningar. Ett sätt att beskriva dessa är den andel av alla tåg som kommer fram mer än fem minuter för senTravel by train has increased steadily in Sweden the last 30 years. The pace has been about two to three percent per year, and we now have twice as many passengers. With growing awareness of the changing climate, the pace is increasing further. A problem that affects both passengers and businesses in Sweden is train delays. One way to describe these is as the share of trains that arrive less than

This thesis makes a contribution to systemic risk literature in the European banking system. The intimate interdependence between the European banking industries and the fragile GIIPS debt market has jeopardized the banking sector in Europe. The threats of unfavourable financial conditions in European bank- ing sufficiently highlight the importance of the dissertation’s distinct focus on systemic

Objective: To investigate fatigue at baseline and 3.5 years later and its association with balance and gait over time.Background: In Parkinson’s disease (PD), fatigue is considered one of the most common and disabling nonmotor symptoms that may persist or even worsen over time. Fatigue in generally has been described as a significantly diminished energy level or an increased perception of effort d

Through improved bitumen characterization, which will increase the road'sdurability, stability, and performance, pavement engineering can apply thesustainability notion that should be followed in all disciplines nowadays. The newtechniques distinguish between the rheological properties of bituminous binders as a function of loading time and temperature to depict real-world behavior rather than onl

BACKGROUND: Qigong includes training for body and mind, one method is Zhineng Qigong. Scientific literature on qigong for chronic low back pain (LBP) is sparse. This study aimed to investigate feasibility including evaluation of a Zhineng Qigong intervention for pain and other lumbar spine-related symptoms, disability, and health-related quality of life in patients with chronic LBP and/or leg pain

Importance: Endovascular treatment is not recommended for aortic pathologies in patients with connective tissue diseases (CTDs) other than in redo operations and as bridging procedures in emergencies. However, recent developments in endovascular technology may challenge this dogma. Objective: To assess the midterm outcomes of endovascular aortic repair in patients with CTD. Design, Setting, and Pa

Aims: We tested whether parental alcohol use disorder (AUD) predicted adult offspring's likelihood of marriage and marriage to an AUD-affected spouse; whether effects differed as a function of the sex or number of affected parents; and whether they were robust to confounders. Design: Sex-stratified Cox and logistic regression models. Setting: Sweden. Participants: A total of 1 171 070 individuals

Background: Out of Hospital Cardiac arrest (OHCA) survivors with ST elevation (STE) with or without shockable rhythms often benefit from coronary angiography (CAG) and, if indicated, percutaneous coronary intervention (PCI). However, the benefits of CAG and PCI in OHCA survivors with nonshockable rhythms (PEA/asystole) and no STE are debated. Methods: Using the International Cardiac Arrest Registr

OBJECTIVES: To characterise autoimmune congenital heart block (CHB) associated with a maternal diagnosis of primary Sjögren's syndrome (pSS) confirmed either before, concomitant or after the first pregnancy complicated with CHB.METHODS: The following inclusion criteria were applied: (i) Mothers with positive Ro/La autoantibodies detected previously or at the time of diagnosis of the first case of

Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when

Objective Survival in epithelial ovarian cancer (EOC) remains poor. Most patients are diagnosed in late stages. Early diagnosis increases the chance of survival. We used the proximity extension assay from Olink Proteomics to search for new protein biomarkers with the potential to improve the diagnostic performance of CA125 and HE4 in patients with ovarian tumors. Material and methods Plasma sample

One of the main issues in context of the severe economical changes on the local media market and the measures the media companies are forced to take is how to maintain high quality of news journalism in the local press. There are concerns that the quality of news will decline and content will be commercialized as McManus (1994) describes it as a market-driven journalism when profit becomes the leaThe local media organisations in Sweden have the last years been involved in initiating new model of business (Melesko 2013). They have mainly been based on economical actions, as cut-downs of editorial staff, integration of different pressrooms and expanded co-operation between papers within same media organisations (Nygren 2013). For instance, editorials and cover of culture news has on several

The members of the genus Caldicellulosiruptor have the potential for future integration into a biorefinery system due to their capacity to generate hydrogen close to the theoretical limit of 4 mol H2/mol hexose, use a wide range of sugars and can grow on numerous lignocellulose hydrolysates. However, members of this genus are unable to survive in high sugar concentrations, limiting their ability t

Background: To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA). Methods: Individuals who developed GCA after inclusion in two population-based health surveys were identified through linkage to the local and the national patient registers. In addition, other patients diagnos

Severe unrestrained behaviors during armed conflicts, such as the massacre in My Lai or abusive transgressions such as the torture-like behaviors occurring in Abu-Ghraib prison, often lead to increased difficulties to decrease hostilities or to gain a peaceful ending to a military conflict. Therefore, it is of highest relevance to understand which individual, situational and organizational factors

Purpose: To investigate associated systemic diseases, other conditions, visual outcome, ocular complications and treatment in Swedish patients younger than 50 years with central retinal vein occlusion (CRVO) and reviewing the literature. Methods: Twenty-two patients with CRVO, younger than 50 years, were examined with full-field electroretinography (ERG) within 3 months after a thrombotic event, o

Unmanned Aerial Vehicles (UAVs) provide a flexible method for acquiring high-resolution imagery with relative simple operation and cost-effectiveness. This technology emerged 30 years ago and it is widely used by commercial, scientific, and military communities due to its versatility. However, new technology brings new challenges. One of them is the radiometric accuracy of the UAV imagery. Radiome

Det internationella skattesamarbetet har under en längre tid definierats av en vilja att motarbeta dubbelbeskattning av enskilda skattebetalare. Det främsta sättet på vilket detta har tagit uttryck är de många bilaterala skatteavtalen som finns mellan olika stater idag. I ett sådant avtal regleras beskattningen av en gränsöverskridande transaktion eller affärsverksamhet mellan de två avtalsslutandThe international tax law system has for a long time been defined by its prevention of double taxation of the taxpayers. The main way in which this work has been undertaken has been the many bilateral tax agreements that exist between states today. These agreements regulate the taxation rights between two states in a case of a cross-border transaction or arrangement. In that way it is possible for