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Popular Science Summary Konsten att kunna ta bort ett syre Alla celler har DNA, som måste repareras och kopieras för att livet ska fortgå. För att kunna göra detta måste det finnas byggstenar. En av alla processer som ser till att alla delar finns i rätt mängd innefattar bara ett protein. Ett protein som får instruktioner från många håll för att gå igenom en komplicerad process som tillverkar dessThe protein ribonucleotide reductase catalyses the de novo synthesis of deoxyribonucleotides (dNTPs) from ribonucleotides (NTPs), using radical chemistry. It is under strict allosteric regulation, partly from the dNTPs it synthesises that regulate what substrate should be synthesised, but also from dATP/ATP, which regulates overall activity. It is a protein that is found in almost every living org

Popular Abstract in English Universal Burdens There are Zen students who are in chains when they go to a teacher, and the teacher adds another chain. The students are delighted, unable to discern one thing from another. This is called 'a guest looking at a guest.' -Linji What do Zen master Linji, Muslim scholar ‘Abbād ibn Sulaymān, and Comanche thinker Parra-Wa-Samen have in common? Among manyZen Buddhists have long given the following advice to attain liberation: “Eat when you’re hungry. Sleep when you’re tired.” In other words: “Freedom” is the “knowledge of necessity” (Hegel, Marx, and Engels). Early Islamic communities dealt with the challenge of internal warfare and tyranny and concluded that, “sixty years of tyranny is better than one day’s anarchy.” In other words, the worst-cas

Under 1900-talets första kvartal arbetade lagstiftaren med att införa nya och revidera gamla lagar på familjerättens område. Många av lagarna hade sett mycket lite förändring sedan deras införande i och med 1734 års lag. År 1915 förändrade man begreppet trolovning och dess innebörd blev mycket mer vidsträckt än vad det tidigare hade varit. Det blev nu ett helt formlöst avtal som ansågs ingånget såDuring the first quarter of the 20th century, the legislator worked to introduce new laws and revise old ones concerning family law, many of which had seen very little change since their introduction in the law of 1734. In 1915, the concept of betrothal changed and its meaning became much more extensive than it used to be. It was now a completely formless agreement that was concluded as soon as th

This research is exploring policy coherence of energy, climate, and biodiversity policies on the case study of new hydropower developments in the Republic of Slovenia. A qualitative case-study approach utilising policy document analysis and interviews was chosen to conduct this research. This analysis revealed that policy objectives were coherent within policy sectors but not across policy sectors

Populärvetenskaplig sammanfattning: Frågan om jordens ålder fick sitt svar först vid 1900-talets början, då upptäckten gjordes att uran sönderfaller till bly med bestämd hastighet. Genom att mäta blyisotoper i uranhaltiga mineral kunde man räkna baklänges och se hur lång tid som krävts för att den uppmätta mängden bly skulle bildas. Samma typ av beräkningar gjorda på mineralet zirkon (ZrSiO2) är iZircon crystals from mafic intrusive rocks and surrounding gneisses were studied using back-scattered electron and cathodoluminescence imaging and laser ablation ICPMS. The rocks are exposed on the island of Norra Horten northwest of Varberg off the western coast of Sweden. The intrusion is mainly made up of amphibolite and metadiorite. Most zircons in the mafic rocks have prismatic external morph

This master's thesis sets out to explore information literacy in a contextualized learning environment with emphasis on students at a vocationally oriented program in the Swedish upper secondary school. The concept of information literacy is widely discussed and furthermore a common subject for research within the field of Library and Information Science. Information literacy can be described

Shrunken pore syndrome (SPS) is a condition in which estimated glomerular filtration rate (eGFR) based upon cystatin C is lower than eGFR based upon creatinine. It has been associated with increased mortality even in the presence of normal GFR in both a cardiac surgical population and a general population. No systematic studies of the varia

We propose drl-RPN, a deep reinforcement learning-based visual recognition model consisting of a sequential region proposal network (RPN) and an object detector. In contrast to typical RPNs, where candidate object regions (RoIs) are selected greedily via class-agnostic NMS, drl-RPN optimizes an objective closer to the final detection task. This is achieved by replacing the greedy RoI selection pro

We report on the detection of a remarkable new fast high-energy transient found in the Chandra Deep Field-South, robustly associated with a faint (mR = 27.5mag, zph ~2.2) host in the CANDELS survey. The X-ray event is comprised of 115+12 -11 net 0.3-7.0 keV counts, with a light curve characterized by an ~100 s rise time, a peak 0.3-10 keV flux of ~5 × 10-12 erg s-1 cm-2 and a power-law decay time

Multi-objective optimization is a crucial matter in computer systems design space exploration because real-world applications often rely on a trade-off between several objectives. Derivatives are usually not available or impractical to compute and the feasibility of an experiment can not always be determined in advance. These problems are particularly difficult when the feasible region is relative

Background: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. Aim of the study: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall pre

Effects of pilot H2 injection on the thermoacoustic instability of premixed CH4/air flames were experimentally investigated with varied hydrogen injection rates and different injection strategies. The flames were stabilized on a swirl burner with a central pilot-fuel injection tube. The flame structure was captured using high-speed OH* chemiluminescence and OH-PLIF methods, while the CO and NOx em

Solar energy is an important source of clean energy to combat climate change issues that motivate the establishment of solar farms. Establishing solar farms has been considered a proper alternative for energy production in countries like Mozambique, which need reliable and clean sources of energy for sustainable development. However, selecting proper sites for creating solar farms is a function of

Around the world today, universities are expected to play a unique role as creators of regional growth and innovation. While there appears to be a consensus that the role of universities has been expanded, critiques show that the contribution of universities to their regions is still not well defined. There have been some developments in the literature on the concept of modern universities such as

Over recent decades, management of people with hemophilia (PwH) has been greatly improved by scientific advances that have resulted in a rich and varied therapeutic landscape. Nevertheless, treatment limitations continue to drive innovation, and emerging options have the potential to realize further improvement. We advocate four general principles to optimize benefits from innovation: individualiz

Low-energy electron diffraction, scanning tunneling microscopy, and photoelectron spectroscopy results from the submonolayer Sm- and Yb-induced surface structures are presented. Several similar metal-induced surface reconstructions are found to exist for Yb and Sm on Si(111) for low submonolayer coverages: 3×2, 5×1, and 7×1. At higher submonolayer coverage, Yb induces a 2×1 reconstruction while Sm

Automated soil moisture systems are commonly used in precision agriculture. Using low-cost sensors, the spatial extension can be maximized, but the accuracy might be reduced. In this paper, we address the trade-off between cost and accuracy comparing low-cost and commercial soil moisture sensors. The analysis is based on the capacitive sensor SKU:SEN0193 tested under lab and field conditions. In a

2021 marked the 30-year anniversary of the publication Fatal Years: Child Mortality in the late Nineteenth-Century United States, a pioneering work in historical demography by Samuel H. Preston and Michael R. Haines. This special issue showcases the current state of historical mortality studies through a collection of articles originally presented at two commemorative sessions at the 2021 meeting

Background Patients with acute coronary syndrome (ACS) are often admitted to monitored wards due to the risk of complications. Several risk prediction scores exist, but their use in the emergency department (ED) is limited. We aimed to compare the ability of existing risk scores with a new logistic regression model in predicting complications in ACS patients. Methods This was a secondary analysis