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The aim of the overview is to give a perspective of global biobank development is given in a view of positioning biobanking as a key resource for healthcare to identify new potential markers that can be used in patient diagnosis and complement the targeted personalized drug treatment. The fast progression of biobanks around the world is becoming an important resource for society where the patient
Diagnostic measurements and pharmacokinetic studies were performed in 17 patients with various kinds of malignant, premalignant and benign lesions in the head and neck region by means of point monitoring laser-induced fluorescence. For marking different types of tissue, delta-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) was used. The ALA-induced PpIX synthesis was monitored at differ
Ribosomal RNAs contain numerous modifications at specific nucleotides. Despite their evolutionary conservation, the functional role of individual 2'-O-ribose methylations in rRNA is not known. A distinct family of small nucleolar RNAs, box C/D snoRNAs, guides the methylating complex to specific rRNA sites. Using a high-resolution phenotyping approach, we characterized 20 box C/D snoRNA gene deleti
The development of inhibitory antibodies to factor VIII is a serious complication of haemophilia. Two haemostatic agents with different bypassing mechanisms have been used in the treatment of patients with inhibitors: activated prothrombin complex concentrate (aPCC) and recombinant factor VIIa (rFVIIa). The objective was to compare cost and outcome of aPCC and rFVIIa in the treatment of joint blee
Popular Science Summary Konsten att kunna ta bort ett syre Alla celler har DNA, som måste repareras och kopieras för att livet ska fortgå. För att kunna göra detta måste det finnas byggstenar. En av alla processer som ser till att alla delar finns i rätt mängd innefattar bara ett protein. Ett protein som får instruktioner från många håll för att gå igenom en komplicerad process som tillverkar dessThe protein ribonucleotide reductase catalyses the de novo synthesis of deoxyribonucleotides (dNTPs) from ribonucleotides (NTPs), using radical chemistry. It is under strict allosteric regulation, partly from the dNTPs it synthesises that regulate what substrate should be synthesised, but also from dATP/ATP, which regulates overall activity. It is a protein that is found in almost every living org
I en värld där många fler människor ska leva på allt färre resurser har matavfall hamnat i ett stort fokus. Svinnet innebär att hela produktionen har gått förlorad. Det är ett ekonomiskt bortfall för företag men även för samhället i stort. Dessutom orsakar hela livsmedelskedjan miljöpåverkan, inte minst från ett klimatperspektiv. De olika aktörerna försöker självklart minska sitt eget svinn men efIn a world where more people must survive on fewer resources, food waste has become greatly focused. Waste means that the entire production has been unnecessary. It is an economic loss for a company but also for society at large. Moreover, the food chain causes an environmental impact, not least from a climate perspective. The various actors certainly try to reduce their own losses but because con
This paper examines how sugar tax effects the prevalence of overweight and obesity. How great price increase which is needed to reduce sugar consumption to recommended levels is also calculated. The Swedish population consumes on average 44% more sugar than the recommended level. The price increase needed to generate a consumption reduction of 44% is calculated from price elasticities for the good
Bygg- och fastighetssektorn är en av de sektorer som släpper ut mest växthusgaser. Under ett enskilt år så svarar byggbranschen för utsläpp av växthusgaser på 21 miljoner ton koldioxidekvivalenter, vilket motsvarar 21 procent av Sveriges totala utsläpp. Av det totala utsläppet på 21 miljoner koldioxidekvivalenter så kommer 12,8 miljoner ton från inhemska utsläpp av växthusgaser och 8,2 miljoner toThe building and real estate sector is one of the sectors that emits the most greenhouse gases. For a single year, the construction industry is responsible for greenhouse gas emissions of 21 million tons of carbon dioxide equivalent, which corresponds to 21 per cent of Sweden's total emissions. Of the total emissions of 21 million carbon dioxide equivalents, 12.8 million tons come from domesti
Due to climate change, emissions of greenhouse gases must be reduced rapidly and natural resources must be used more sustainably. The public sector should lead the way to a more sustainable society and healthcare has been identified as an area that contributes to large emissions. The purpose of this study was to identify measures that can be taken to reduce the climate impact of the retirement ho
Experience with crash prediction modeling has confirmed the importance of traffic volume, not only as exposure but also as a predictive variable. For intersection-related collisions, for example, angle collisions or any collisions involving turning vehicles, traffic volumes on both intersecting roads are necessary for sufficient prediction of crash count These collisions occur not only at intersec
Kerstin Thorvall (1925–2010) is a Swedish author of books for children and young adults, as well as books for adults. In 1965, she wrote the article “Do all authors of children's books live in Tomtebolandet?” (“Bor alla barnboksförfattare i Tomtebolandet”, Expressen 1965) in which she claims that gender roles in Swedish children's literature, are depicted in an old and stereotypical fashion. She a
Theoretical and empirical research often points to a positive relation between corporate sustainability and organisational performance; however, attempts to conceptualise the multi-dimensional nature of sustainability practices are rare in the current literature. Thus, the purpose of this paper is to present a conceptual framework to aid in understanding and explaining the relationship between sus
AimTo identify the factors responsible for the low health-related quality of life associated with foot ulcers and the relative importance of these factors. MethodsA total of 1232 patients with a new foot ulcer, who presented at one of the 14 centres in 10 European countries participating in the Eurodiale study, were included in this cross-sectional study. Patient and ulcer characteristics were obt
Monte Carlo simulations and coarse-grained modelling have been used to analyze Histatin 5, which is an unstructured short cationic salivary peptide known to have anti-candidical properties. The calculated scattering functions have been compared with intensity curves and the distance distribution function P(r) obtained from SAXS, at both high and low salt concentrations. The aim is to achieve a mol
Enol MEM ethers 4 and 15 and the corresponding enol acetates were hydrogenated over Pd/C with very high (>99%) diastereoselectivity to saturated -lactones. A stereochemical generalization can be formulated thus: trans-5,6-disubstituted 1-oxa-3-cyclohexen-2-ones (e.g. 14 and 15) are hydrogenated over Pd with high selectivity from the side trans to the C(6)-substituent. A mechanistic rationalization
Populärvetenskaplig sammanfattning: Frågan om jordens ålder fick sitt svar först vid 1900-talets början, då upptäckten gjordes att uran sönderfaller till bly med bestämd hastighet. Genom att mäta blyisotoper i uranhaltiga mineral kunde man räkna baklänges och se hur lång tid som krävts för att den uppmätta mängden bly skulle bildas. Samma typ av beräkningar gjorda på mineralet zirkon (ZrSiO2) är iZircon crystals from mafic intrusive rocks and surrounding gneisses were studied using back-scattered electron and cathodoluminescence imaging and laser ablation ICPMS. The rocks are exposed on the island of Norra Horten northwest of Varberg off the western coast of Sweden. The intrusion is mainly made up of amphibolite and metadiorite. Most zircons in the mafic rocks have prismatic external morph
Over the last decade the music festival sector grew enormously: in 2008 over a million festivalgoers gathered in the UK to share music and companionship. However in doing so musicfestivals generate large volumes of waste streams and consume large quantities of resources. Amusic festival of more than 40 000 people will produce in the order of 2000 tons of CO2e –with audience transportation and on s
This report is a result of a Master Thesis made at Volvo 3P and the Department of Advance Engineering and Concepts. The thesis is a part of the education in Mechanical Engineering at the Department Design Sciences, for the Division of Machine Design at Lund University. Volvo 3P is involved in a project regarding a new patented manufacturing method that is under development. The manufacturing metho
To allow the user interface in a mobile phone more space, slide modules are implemented. The usage of slide modules introduces many new challenges when designing a mobile phone. New solutions to these challenges is the main scope for this thesis. Nokia currently has several different slide phones out on the market implementing some sort of slide module. The slide module provides extra space for th
Uppsatsens syfte var att utreda huruvida kriminalisering av narkotikabruk var att betrakta som godtagbart ur ett strikt rättsteoretiskt perspektiv. Den svenska narkotikastraffrätten har vuxit fram över lång tid, men har under det senaste halvseklet kommit att innehålla strängare straff och vidgat omfång. Länge ansågs kriminalisering av bruk inte vara önskvärt, något som dock skedde i slutet av 19The purpose of this thesis has been to find out whether criminalization of drug use is acceptable from a jurisprudential perspective. The Swedish criminal legislation regarding drugs has developed over some time. For the last half decade, the scope of the law has broadened and punishments have become harsher. For a long time, criminalization of drug was not deemed necessary, but a law to that exte
