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An economic evaluation of combination treatment with budesonide and formoterol in patients with mild-to- moderate persistent asthma

Patients with mild asthma may benefit from increasing their inhaled corticosteroid dose, adding a tong-acting beta(2)-agonist, or both. This study assessed the cost-effectiveness of these options. Patients aged greater than or equal to12 years with mild-to-moderate persistent asthma (n = 1272) were randomised to twice-daily, double-blind treatment with budesonide 100 mug, budesonide 100 mug plus f

Patterns of normal change in cervical length and width during pregnancy in nulliparous women: a prospective, longitudinal ultrasound study

OBJECTIVES: To determine what constitutes normal changes in the uterine cervix visible at transvaginal ultrasound examination from 24 gestational weeks until delivery in nulliparous women delivering at term. DESIGN: Cervical length and width were measured using transvaginal ultrasound, and the inner cervical os was assessed as being closed or open every 2 weeks from gestational week 24 until deliv

Integration of Molecular Biology and Morphology in Effusions with Focus on in situ Detection of Telomerase and its Components

Popular Abstract in Swedish Den viktigaste uppgiften inom den kliniska cytologin är att påvisa cancerceller i olika typer av cellprover. Många olika cancertumörer sprider sig till lungsäcken och bukhålan och ger då ofta upphov till vätska (exsudat) som innehåller cancerceller. Ofta kan cancerdiagnosen ställas på grundval av cellernas utseende men detta är inte alltid möjligt, eftersom cancercellerClinical cytology is a rapid method to detect malignancy in effusions of the serous cavities, but the morphological characteristics of the cells do not always allow diagnosis and a specific marker for malignant cells would improve the diagnostic performance. Telomerase adds telomere repeats to the chromosome ends. It is the most promising universal indicator of malignancy and the project focuses o

Males are sensitive - sex-dependent effect of rearing conditions on nestling growth

The sex-dependent effect of environmental conditions on nestlings has been extensively studied in size dimorphic birds. Whether males or females are more sensitive to poor conditions is not yet clear; however, the degree of sexual size-dimorphism, brood size and their interactions seem to influence the pattern. Much less is known about sex-dependent environmental sensitivity in size-monomorphic sp

Importance of factors determining the low health-related quality of life in people presenting with a diabetic foot ulcer: the Eurodialestudy

AimTo identify the factors responsible for the low health-related quality of life associated with foot ulcers and the relative importance of these factors. MethodsA total of 1232 patients with a new foot ulcer, who presented at one of the 14 centres in 10 European countries participating in the Eurodiale study, were included in this cross-sectional study. Patient and ulcer characteristics were obt

Advancing Software Development Efficiency in an Open Source Software Context

Open source software has been gaining popularity, especially among commercial organizations. The broad industry acceptance is in large part due to the demonstrated ability of open source solutions to compete with proprietary alternatives. Using open source software components enables companies to reduce their own development costs, and thus improve software development efficiency. Many open source

Direct and indirect impacts of climate and socio-economic change in Europe : a sensitivity analysis for key land- and water-based sectors

Integrated cross-sectoral impact assessments facilitate a comprehensive understanding of interdependencies and potential synergies, conflicts, and trade-offs between sectors under changing conditions. This paper presents a sensitivity analysis of a European integrated assessment model, the CLIMSAVE integrated assessment platform (IAP). The IAP incorporates important cross-sectoral linkages between

Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1

An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-specificity of antibodies to toxic shock syndrome toxin (TSST-1) was investigated by a solid-phase radioimmunoassay. TSS-patients lacked pre-immu

Are emotions important for good interaction in treatment situations?

Emotional aspects in interaction have been an area of growing interest in recent decades.The aims of this research were to investigate the role of emotions in interactions between individuals receiving physiotherapy and their therapists providing PT services to them in psychiatric care. The study was a qualitative case study with cross-case analysis according to Shephard et al (1993) and Merriam (

The MreB-like protein Mbl of S. coelicolor A3(2) depends on MreB for proper localization and contributes to spore wall synthesis.

Most bacteria with a rod-shape morphology contain an actin-like cytoskeleton consisting of MreB polymers which form helical spirals underneath the cytoplasmic membrane to direct peptidoglycan synthesis for elongation of the cell wall. In contrast MreB of Streptomyces coelicolor is not required for vegetative growth, but has a role in sporulation. Beside MreB, S. coelicolor encodes two further MreB

DNA building blocks: keeping control of manufacture

Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substra

Syntes och design : Den intellektuelle politikern som konstnär

Popular Abstract in Swedish Hur löser den intellektuelle politikern problem och hur skapas kontakten med den politiska omgivningen? Svaren på frågorna skall kortfattat presenteras och är intressanta för politiker, partier, väljare och forskare. Svaren visar nämligen hur intellektuella politiker under kristider producerar och presenterar innovativa lösningar som kan få stor betydelse för samhällsutA new theory on the intellectual politician, which has the ability to produce a designed type of problem-solving, has been developed from political science theory, cognitive theory as well as art theory. A cognitive concept, modified integrative complexity, consisting of four sub-concepts, frame reflection, differentiation, reframing and integration has been developed. The relation between politic

Hemodilution during bone marrow harvesting in children

Eight children (1--17 yr) underwent bone marrow harvesting while in cytostatic-induced remission of their disease (leukemia [n = 6], Ewing sarcoma, and non-Hodgkin lymphoma). After the induction of general anesthesia, all patients were loaded with 10 mL/kg of a 6% high-molecular dextran solution (Macrodex — Pharmacia), which resulted in a significant preoperative decrease in hematocrit (Hct) from

Strain in semiconductor core-shell nanowires

We compute strain distributions in core-shell nanowires of zinc blende structure. We use both continuum elasticity theory and an atomistic model, and consider both finite and infinite wires. The atomistic valence force-field (VFF) model has only few assumptions. But it is less computationally efficient than the finite-element (FE) continuum elasticity model. The generic properties of the strain di

Intravenous zoledronic acid in postmenopausal women with low bone mineral density

Background: Bisphosphonates are effective agents for the management of osteoporosis. Their low bioavailability and low potency necessitate frequent administration on an empty stomach, which may reduce compliance. Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explore

Invasion under a trade-off between density dependence and maximum growth rate

The invasion of alien species and genotypes is an increasing concern in contemporary ecology. A central question is, what life-history traits enable invasion amidst populations of wild species and conventional cultivars? In order to invade, the initially rare species must perform better than their resident competitors. We conducted a mathematical analysis and simulation of a two-species extension

Homosexual-themed Advertisement in Mainstream Media: Heterosexual Consumer’s Attitude Toward the Brand and its Social Impact

Nowadays, consumers are daily exposed to an overflow of content in mainstream media. Many companies have developed a trend where they target different sexual orientations as separate segments in order to create a closer relationship to all consumers. However, when companies use homosexual themes in their advertising, it can be perceived as a sensitive area, especially when including minority group

Åklagaren som exekutiv producent - Det videoinspelade förhörets förenlighet med grundläggande rättssäkerhetsprinciper, med särskild betoning på kontradiktion, parternas likställdhet, rätten till korsförhör och omedelbarhet

Brottsligheten i Sverige har på senare tid blivit alltmer komplicerad och omfattande, vilket har inneburit allvarliga påfrestningar både för rättssystemet och för de enskilda som på något sätt har varit inblandade i dessa mål. Med anledning härav tillsattes den 7 april 2016 ett antal särskilda utredare med uppgift att undersöka hur straffprocessen i stora brottmål skulle kunna effektiviseras med bIn recent years, criminal behaviour has changed quite a bit due to an increased internationalization and an advanced use of internet. As a result, the frequency of complex and large-scaled crimes has increased remarkably, which has caused the Swedish judicial system great difficulties. Both the crime investigations and the legal proceedings in these cases require huge recourses, and additionally,