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The effect of the pineal indole hormone melatonin on the life span of mice, rats and fruit flies has been studied using various approaches. It has been observed that in female CBA, SHR, SAM and transgenic HER-2/neu mice long-term administration of melatonin was followed by an increase in the mean life span. In rats, melatonin treatment increased survival of male and female rats. In D. melanogaster
The ever increasing volume of air transport necessitates new technologies to be adopted by the flight industry to fulfill the requirements of safety, security, affordability, and environmental friendliness while still meeting the growing demand. What we need to achieve this goal is a new type of aircraft cruise control, interconnecting all the onboard active control systems and making more accurat
The spinocerebellar systems are essential for the brain in the performance of coordinated movements, but our knowledge about the spinocerebellar interactions is very limited. Recently, several crucial pieces of information have been acquired for the spinal border cell (SBC) component of the ventral spinocerebellar tract (VSCT), as well as the effects of SBC mossy fiber activation in granule cells
Zooplankton accumulate several groups of photoprotective compounds to shield against damaging ultraviolet radiation (UV). One of these groups, the carotenoids, makes the animals more conspicuous to visually hunting predators, whereas others, such as the mycosporine-like amino acids (MAAs) may not. The blend of photoprotective compounds is therefore important for the UV defense but also for the abi
Accurate assessment of early hip joint cartilage alterations may help optimize patient selection and follow-up of hip joint preservation surgery. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA). Hence, the dGEMRIC technique holds promise for the deve
Chronic obstructive pulmonary disease (COPD) independently associates with an increased risk of coronary artery disease (CAD), but it has not been fully investigated whether this co-morbidity involves shared pathophysiological mechanisms. To identify potential common pathways across the two diseases, we tested all recently published single nucleotide polymorphisms (SNPs) associated with human lung
Popular Abstract in Swedish Fåglar har fascinerat människor i århundraden. Färgen på deras fjädrar, deras flyghöjd och deras förmåga att fånga små byten har skapat den allmänna uppfattningen att fåglar har en fantastisk syn. Föreställningen att fåglar har skarpare syn än människor är väletablerad hos jägare och fiskare och finns att hitta i litteraturen. Det finns emellertid tusentals fågelarter oAvian eyes are big both in relative and absolute terms, thus the importance of vision to birds is obvious. Even though the general eye plan is rather conservative throughout the group, there is a great variation in visual capabilities. In this thesis I present four studies on different aspects of spatial vision in parrots, procellariiform seabirds and birds of prey. In Paper I we studied retinal g
Measurements in a road tunnel in Stockholm, Sweden give the real-world traffic emission factors for a number of gaseous and particle pollutants. These include 49 different polycyclic aromatic hydrocarbons (PAH), CO, NOX, benzene, toluene, xylenes, aldehydes, elements and inorganic/organic carbon contained in particles, the sub-micrometer aerosol number size distribution, PM2.5 and PM10. The exhaus
Popular Abstract in Swedish Bakgrund: Det första elektrokardiogrammet (EKG) utfördes 1887 av Augustus Desiré Waller. Det innebar att spänningsskillnader mellan olika delar av hjärtat, under hjärtats arbete dvs. vid upprepade sammandragningar och avslappningar, kunde registreras med elektroder på kroppens yta. Metoden utvecklades vidare av Willem Einthoven, som fick nobelpriset för sitt arbete 1924Background and Methods: Signal-averaging ECG (SAECG), a bioelectrical processing method, is a further development of the conventional ECG. SAECG can detect voltage potentials in the microvolt range and provide a noise-reduced determination of QRS duration. Extended frequency spectra can be analysed. In adult patients after myocardial infarction it is used to predict the risk for arrhythmias and su
Background: Oxidation of LDL is associated with generation of autoantibodies against a large number of different aldehyde-modified peptide sequences in apo B-100. Autoantibodies recognizing peptide sequences in the LDL receptor-binding region of apo B-100 could potentially affect both cholesterol metabolism and atherosclerosis. The aim of the present study was to determine physiological effects of
AIM: The purpose of the study was to explore the effects of using a structured nursing intervention programme in hypertension care. BACKGROUND: Counselling on lifestyle changes to address hypertension helps patients reduce risk factors such as smoking, high alcohol consumption, overweight, dyslipidemia, negative stress and physical inactivity. DESIGN: The study was performed as a pre-test-post-tes
The Kaposi's, sarcoma-associated herpesvirus (KSHV) complement control protein (KCP) inhibits the human complement system, and is similar in structure and function to endogenous complement inhibitors. Other inhibitors such as C4d-binding protein and factor H, as well as the viral homologue vaccinia virus complement control protein are known to bind heparin and, for the two latter, also to glycosam
Background: As the incidence of allergy to different compounds increases in society, the need to understand and characterize specific IgE responses becomes F. obvious. Different cell culture systems have been evaluated for their ability to support such IgE secretion. Methods: One system employed human peripheral lymphocytes (PBL) from normal donors stimulated with anti-CD3 activated T cells with o
According to Silvan Tomkins’ (1963, 1965) Polarity Theory, all ideologies are polarized by a fundamental conflict between Humanism, which idealizes and glorifies humanity, and Normativism, which portrays human beings as inherently worthless and able to attain value only through achievement of external norms. Research has shown that Humanism and Normativism do indeed form two coherent and negativel
Popular Abstract in Swedish Hudfibros, inre organengagemang och autoantikroppar vid systemisk skleros: longitudinell utveckling och effekt på överlevnad. Systemisk skleros kallas ofta för sklerodermi. Sjukdomen tillhör de systemiska bindvävssjukdomarna och handläggs i Sverige oftast av reumatologer. Kardinalsymtomet vid sklerodermi är förhårdnad hud vilket gett sjukdomen den dess namn. Sklero betySystemic sclerosis (SSc) is a connective tissue disease with a highly variable prognosis. Since new treatment strategies are emerging, there is a need for prognostic markers in order to help allocate patients to the optimal treatment. When comparison is made to the general population, there is an increased mortality rate in this study, both in the series as a whole and in the subgroups of men and
This study investigates the topic of forgiveness of sins in the mission of the historical Jesus. Gospel material that pertains to the question is authenticated by the use of criteria for historicity and interpreted within the wider context of first-century Judaism as part of a broader reconstruction of Jesus’ career as a healer and prophet. Questions posed and answered concern the historical plaus
The microflora of Herrgård cheese produced at three dairies was compared after three and six months maturation. The microflora of cheeses from two of the dairies was dominated by a spontaneous microflora of Lactobacillus after three months of ripening, while starter bacteria still dominated in cheese from the third dairy after six months. Isolates were typed by the PCR-based method Randomly
Popular Abstract in French Phytoplancton invasif : génétique des populations, phylogéographie, et facteurs facilitant l’invasion par Gonyostomum semen De nos jours, les espèces invasives représentent une importante menace à la biodiversité. Une espèce invasive colonise un nouvel environnement, ou elle était absente, et atteint de forte densité rapidement, diminuant l’abondance ou remplaçant les esnvasive species is a major threat to ecosystems and biodiversity. Invasions by macroorganisms have been intensively studied, but little is known concerning microbial invasions. In aquatic environments, phytoplankton, i.e. autotrophic microbes, have a key role as primary producers. In my thesis, I focused on the population genetic structure and phylogeography of the freshwater raphidophyte Gonyosto
BackgroundDimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. Study Design and MethodsIn this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma
This paper investigates the decision-making processes of mayors on the municipal level in Brandenburg, Germany, to support 100% renewable energy policies as well as the respective key success factors. Three different cases and their specific settings are examined: (1) Turnow-Preilack with Germany's largest solar power plant, (2) Prenzlau, a town claiming the title 'City of Renewable Energy’ and (3
