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Background: 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice. However, the significance of CYP27A1 expression on BC biology and prognosis is unclear. Methods: Intratumoral CYP27A1 expression in invasive BC was measured by immunohistochemist

Dwarf males (nannandry) occur in many unrelated, mostly aquatic, groups of organisms. Among land plants they are unique to bryophytes. In this study our aim was to explain variation in frequency of dwarf males and fertilization within populations in the moss Homalothecium lutescens. We compared parameters related to dwarf male presence and sporophyte production in 90 colonies from three localities

Background: Targeted temperature management is recommended after out-of-hospital cardiac arrest and may be achieved using a variety of cooling devices. This study was conducted to explore the performance and outcomes for intravascular versus surface devices for targeted temperature management after out-of-hospital cardiac arrest. Method: A retrospective analysis of data from the Targeted Temperatu

Low energy buildings have well insulated building enclosures and efficient ventilation heat recovery systems which lead to small transmission and ventilation heat losses. During a large part of the year internal heat gains from people, household electricity and solar heat gains balance the heat losses with zero heating need as a result. All energy uses in a building are part of the buildings energ

Background: Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [18F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheime

In the aircraft industry maximizing availability is essential. Maintenance schedules must therefore be opportunistic, incorporating preventive maintenance activities within the scheduled as well as the unplanned ones. At the same time, the maintenance contractor should utilize opportunistic maintenance to enable the minimization of the total expected cost to have a functional aircraft engine and t

Crop growth simulation models can differ greatly in their treatment of key processes and hence in their response to environmental conditions. Here, we used an ensemble of 26 process-based wheat models applied at sites across a European transect to compare their sensitivity to changes in temperature (-2 to +9°C) and precipitation (-50 to +50%). Model results were analysed by plotting them as impact

Neurodevelopmental disorders (Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), tic disorder, intellectual disability (ID)), in prison populations have received increased attention but the focus has generally been on one single condition leaving out the global picture. This study assessed the prevalence and overlap of neurodevelopmental disorders (NDD) in a consecuti

IMPORTANCE Prostate cancer commonly metastasizes to bone, and bone metastases are associated with pathologic fractures, pain, and reduced survival. Bone disease is routinely visualized using the technetium Tc 99m(99mTc) bone scan; however, the standard interpretation of bone scan data relies on subjective manual assessment of counting metastatic lesion numbers. There is an unmet need for an object

Compared to other regions, the drivers of diversification in Africa are poorly understood. We studied a radiation of insects with over 100 species occurring in a wide range of habitats across the Afrotropics to investigate the fundamental evolutionary processes and geological events that generate and maintain patterns of species richness on the continent. By investigating the evolutionary history

BACKGROUND: Sustained intrauterine hypoxia causes some four million perinatal deaths annually worldwide. The condition is predicated by neonatal acidemia, as determined by pH in umbilical cord blood at birth. We aimed to evaluate the association between umbilical cord arterial pH and long-term outcomes up to 20 years of follow-up.STUDY DESIGN: Using a retrospective cohort design, umbilical cord ar

Despite growing interest in community-based ecotourism as a pathway to sustainable development, there is a critical lack of research on how localized configurations of marketing and policy factors shape ecolodge performance at the village level. This study addresses this gap by pioneering a comprehensive, contextually grounded analysis of the availability and desirability of key marketing and poli

The Web Accessibility Directive (WAD) is part of the European Union’s work for digital inclusion. The WAD obligates that public sector bodies’ websites meet accessibility standards and provide an accessibility statement on the website informing about inaccessible content, and a feedback mechanism for reporting accessibility issues or requesting inaccessible content in an accessible format. The obj

Background: Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating longitudinal outcomes over an extended period of time are limited. Therefore, we aimed to investigate clinical outcomes up to 9 years after amyloid-PET to support the clinical validity of the imaging technique. Methods: We analyzed longitud

In this paper, we explore contemporary regional development in a historic industrial region. Specifically, we unpack the influences of industrial history and culture, built up over several centuries, on contemporary regional development dynamics and issues. In doing so, we draw on an evolutionary perspective within economic geography and perspectives from deindustrialization studies to understand

The tazkera (national ID) is Afghanistan’s most important identity document and necessary to receive a variety of government services (e.g. education), employment, or even other identity documents such as passports or driver’s licenses. While the most commonly held identification by Afghans, certain groups own tazkeras far less than do others, especially women and rural, displaced and nomadic popu

This abstract is based on a pilot study from an ongoing project focusing the implementation of a digital platform offering support for both the patient- and workflow at a primary healthcare center in Western Sweden. The overarching aim of the project is to follow the introduction and adaptation (normalization) of the platform in primary healthcare centers to study how digital support of the patien

Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study. Methods: Targeted mass spectrometry metabolomics

In a multi-storey residential housing project comprising of four 8-storey timber buildings, the bottom storeybeing designed with concrete and storeys 2-8 in timber, the vertical relative displacement, the temperature and the relativehumidity (RH) along one vertical channel in the external wall of one building has been monitored. Measurements startedduring construction and presented herein are r