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The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)
Sustainable low melting temperature bicomponent polyester fibers that can be circularly recycled were developed. The potentially biobased poly(hexamethylene terephthalate) (PHT), acting as the low melting temperature sheath material in the designed bicomponent fibers, was synthesized in a pilot scale. The obtained PHT with an intrinsic viscosity of 0.47 dL/g showed suitable processability when it
Objective: To evaluate the influence of implant and prosthetic components on peri-implant tissue health. A further aim was to evaluate peri-implant soft-tissue changes following surgical peri-implantitis treatment. Materials and methods: Group discussions based on two systematic reviews (SR) and one critical review (CR) addressed (i) the influence of implant material and surface characteristics on
Background: Patients with perioperative myocardial injury are at risk of death and major adverse cardiovascular and cerebrovascular events (MACCE). The primary aim of this study was to determine optimal thresholds of preoperative and perioperative changes in high-sensitivity cardiac troponin T (hs-cTnT) to predict MACCE and mortality. Methods: Prospective, observational, cohort study in patients ≥
Motivated by the pioneering activation-energy asymptotic analysis of strained laminar premixed flames in counterflow by Libby and his coworkers, a rate-ratio asymptotic analysis is carried out to elucidate the structure and predict the critical conditions of extinction of strained premixed methane flames. Steady, axisymmetric, laminar flow of two counterflowing streams: a reactive mixture stream a
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and cell death in cartilage are among the first signs
Apart from classical orthostatic hypotension, the gravitational force may strongly contribute to other forms of orthostatic intolerance, delayed and postprandial OH, postural orthostatic tachycardia syndrome (POTS), and reflex syncope. In delayed OH, the significant blood pressure drop occurs first after 3-min period of orthostasis, whereas in postprandial OH, the symptoms appear first approximate
Dense urban morphologies further amplify extreme climate events due to the urban heat island phenomenon, rendering cities more vulnerable to extreme climate events. Here we develop a modelling framework using multi-scale climate and energy system models to assess the compound impact of future climate variations and urban densification on renewable energy integration for 18 European cities. We obse
A small, nucleotide-binding domain, the ATP-cone, is found at the N-terminus of most ribonucleotide reductase (RNR) catalytic subunits. By binding adenosine triphosphate (ATP) or deoxyadenosine triphosphate (dATP) it regulates the enzyme activity of all classes of RNR. Functional and structural work on aerobic RNRs has revealed a plethora of ways in which dATP inhibits activity by inducing oligome
Non-bee pollinators (NBP) are a group of species with very diverse ecology. Indeed, they inhabitvarious habitats, using these as nesting sites, for shelter, as source of food and as huntingground for prey. Depending on the life stage of species, NBPs can inhabit different areas andtheir overall contribution to pollination can be diverse. For example, adult butterflies mainlyforage on nectar, where
Purpose: To evaluate inter- and intrarater reliability, of the Eating and Drinking Ability Classification System (EDACS) for children and adults with cerebral palsy (CP) in Sweden. Methods: Four speech and language pathologists rated EDACS from videos of 30 individuals with CP, 3 to 62 years, (mean 21 y, 10 m, SD 18 y, 6 m), six at each level of the Gross Motor Function Classification System (GMFC
Syftet med denna avhandling är att undersöka användningen av naturrättsligt språkbruk i de danska agrarreformerna, cirka 1750-1800. Detta görs genom en social kontextualisering som fokuserar på de sprickor som fanns i det danska samhället före och under reformperioden. Jag hävdar att dessa huvudsakligen utgjordes av interna materiella skillnader inom den danska jordägande eliten, inklusive deras oPopular science description The agrarian reforms of the 18th century were some of the most momentous historical events in Danish history. In the span of 30 years, half of all peasants went from living in a state of serfdom to owning and cultivating their own plots of land, free from the onerous ties of manorial dependence that they had toiled under for hundreds of years. In this pioneering dissert
Skolämnet Idrott och hälsa (IDH) har ett brett innehåll eftersom det inkluderar både idrottsaspekter och hälsoaspekter. Tidigare studier har visat att idrott-delen dominerar på flera sätt, delvis på grund av ett vagt och icke-specifikt ämnesspråk i ämnesplaner, kursplaner och läromedel (Lundin & Schenker 2021, 2022; Lundin m.fl. 2021, 2023). Detta resulterar i att hälsoaspekterna av ämnet inteThe school subject Physical Education and Health (PEH) has a wide scope with respect to its content, combining the aspects ‘sports’ and ‘health’. Previous studies have shown that for the Swedish school subject PEH, sports dominate the content of the subject in several aspects, as a result of, for instance, a vague and unspecific subject specific literacy used in the curricula and course books (Lun
This research study investigates the response of clay brick masonry with different crack widths before and after repointing subjected to water spray. In doing so, 3-course masonry prisms containing artificial cracks were exposed to a water spray during 23 hours of testing. Forty-nine cracked 3-course masonry prisms were prepared with a crack width varying between 0.3 mm and 0.9 mm, whereas thirtee
A novel method to enhance the heat transfer on the internal tip surface of gas turbine blades was developed. Effects of delta-winglet vortex generators (DWVG) and their angle of attack on the vortical structures and mechanism of enhanced heat transfer were investigated. Seven different angles of attack were considered: 0°, 15°, 30°, 45°, 60°, 75°, and 90°. The Reynolds number varies from 10,000 to
Microsoft Word - Thesis, 2011-06-01 (statiska referenser).docx Scouting for Sustainable Development A study of some young people’s environmental views within the Scout Movement By: Lovisa Lönegren lovisen@hotmail.com Supervised by: Lena Christensen lena.christensen@lucsus.lu.se Lund University Center for Su
https://www.lumes.lu.se/sites/lumes.lu.se/files/lonegren_lovisa_thesis_2011.pdf - 2026-06-23
FINAL SIMM16 190220.pdf SIMM16 GRADUATE SCHOOL, FACULTY OF SOCIAL SCIENCES, LUND UNIVERSITY Introduction to Quantitative Methods Spring 2019, version 1.0 For an always up-to-date online version, please visit the course site (check regularly for updates) Welcome! SIMM16 Welcome to the Autumn term’s course Introduction to Quantitative Methods The aim of this course is for students with little prio
https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/final_simm16_190220.pdf - 2026-06-23
Hjärnkoll förändrar attityder Uppföljning och effektutvärdering av Hjärnkoll Datum 2012-06-01 Diarienummer 2012/0002 Handisam, Myndigheten för handikappolitisk samordning, 2012 Titel: Hjärnkoll förändrar attityder Handisam Serie A 2012:4 (diarienummer 2012/0002) Utredare: Rickard Bracken Rapporten finns att ladda ner från Handisams webbplats www.handisam.se. Alternativa format kan beställas från H
https://www.cepi.lu.se/sites/cepi.lu.se/files/hjarnkoll_forandrar_attityder.pdf - 2026-06-23
On Integration of Technology, Media and Mediation Inter Arts Center, Malmö October 11-12, 2023 This seminar discusses methods to integrate sound and image and text. One focus is on what counts as media in this specific practice: the text, music, sound, the live performances of actors’ and musicians’? Or is the art form itself a medium? Another field of interests is how and what is mediated through
https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2023-11/seminar%20on%20technology.pdf - 2026-06-23
Development Plan for the Department of Political Science Page 1 of 6 Faculty Board DEVELOPMENT PLAN Reg. No. STYR 2018/2041 2019-11-21 Development Plan for the Department of Political Science Background The evaluation was carried out during the spring semester of 2019 and covered the Bachelor’s programme in Political Science and the Masters’ programmes in Political Science, European Affairs and We
