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Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

Stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1), and proteoglycan fragments were quantified in knee synovial fluid samples in a cross-sectional study of patients who had injury to the anterior cruciate ligament or the meniscus. The average concentrations of stromelysin-1 and TIMP-1 increased 25-fold and 10-fold within the first day after the trauma, respectively, and the concentra

In the present study, using retinal ischemia as a model, we examined if different periods of ischemia and recirculation influenced the generation of reactive oxygen species, i.e. in hydrogen peroxide generation and nitroblue tetrazolium (NBT) reduction. Ischemia was induced for 30 and 90 min by ligation of the optic nerve with the vessels and recirculation was established by removing the ligature.

The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention.

Background: Use of bio-based diesel is increasing in Europe. It is currently produced from oilseed crops, but can also be generated from lignocellulosic biomass such as straw. However, removing straw affects soil organic carbon (SOC), with potential consequences for the climate impact of the biofuel. This study assessed the climate impacts and energy balance of biodiesel production from straw usin

Hushållens skuldsättningsgrad i Sverige är hög både internationellt och historiskt sett och förväntas fortsätta växa under många år framöver. Hushållens höga skuldsättning gynnar den ekonomiska tillväxten i landet. Samtidigt kan det innebära en risk för den finansiella stabiliteten och för den svenska ekonomin i stort. Hög skuldsättning och stigande bostadspriser har förvärrat konjunkturnedgångar The Swedish household debts are, both internationally and historically, high and are expected to increase for many years to come. High household debt is beneficial for the economic growth in the country, but may at the same time implicate a risk to the financial stability and for the Swedish economy in general. High household debts and rising housing prices have made economic turndowns worse in se

The purpose of this project was to create a risk model for extended time between major overhauls on steam turbines. The project was created by Siemens Industrial Turbomachinery who develops and manufactures steam turbines and performs maintenance. It is the turbine users who have requested a longer time in order to reduce maintenance costs and increase availability. Prior to the work, external and

As mass timber construction gains momentum worldwide, cross-laminated timber (CLT) has emerged as an important material in the built environment. However, the combustible nature of wood presents challenges and fire safety concerns, and a key interest with respect to CLT is the adhesive bond line. CLT is commonly used in ceiling configuration, and current fire stability evaluations rely predominant

This study analyzed daily temperature data from 114 meteorological stations in the Qinling-Daba Mountains from 1980 to 2017, focusing on core zones (CE I ≥ 2274 m, CE II 1321–2274 m) and peripheral zones (PE I 668–1321 m, PE II < 668 m). Using 15 extreme temperature indices computed with RClimDex, we assessed the spatiotemporal patterns, trends, and response to climate warming of extreme temperatu

The Cone Calorimeter is the most complete reaction-to fire test apparatus available presently. It measures heat release rates and mass loss rate, ignitability properties and smoke and toxic gas production rate. One of the main advantages remains in its wide spread and use. There are, however, some drawbacks in the cone calorimeter that should be noticed and maybe corrected for. The sample size is

Popular Abstract in Swedish Trumljud är det ljud som hörs i ett rum då ett objekt, till exempel en fot, träffar golvytan i samma rum. Ökande användning av tunna och hårda golvbeläggningar, såsom parkett och laminatgolv, kan leda till ljudstarka och skarpa ljud, vilket har ökat intresset av trumljud. En prediktionsmodell för den subjektiva responsen av trumljud vid en parvis jämförelse har tagits fDrum sound is the sound produced when an object, such as a foot, hits the flooring in the room in which the receiving ear is located. Drum sound has attracted interest in recent years, particularly due to an increased use of thin floating floor constructions, such as veneer or laminate flooring, which can produce loud and sharp walking sound. A prediction model of the subjective response, in a pai

AIMS: The aim of this study was to determine the incidence of valve-related complications in patients with a mechanical aortic valve prosthesis and to identify risk factors for an adverse outcome.METHODS AND RESULTS: In the 424 patients, event-free survival rates 5 and 10 years after aortic valve replacement were 62% and 37%, respectively. The linearized incidence of thromboembolic events was 4.4%

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin

For a train speed close to the speed of elastic waves in the soil, often referred to as “critical speed”, largely elevated vibration responses occur. This can be a practical problem for soft soil sites, where the phenomenon may cause excessive vibrations in the track and also at distances far from the track. To ensure the running safety of the train, the long-term quality of the track and to reduc

Work-life balance är ett arbetsmiljöproblem som är av ökande relevans på både organisations- och individnivå. Ämnet är särskilt relevant för gymnasielärare, ett yrke som har sett en ökad grad av utbränning och långtidssjukskrivning under de senaste åren. Studien syftar till att analysera hur gymnasielärares fritid, arbete och work-life balance hänger samman och påverkar varandra och ifall det finn

The services provided by the Cell and Gene Technologies Core Facility are available to all internal and external academic customers. StemTherapy and MultiPark users have priority access. We offer the following services:Consultation and TrainingiPS ServicesmRNA Production ServicesCRISPR ServicesVector Production Services (AAV & Lentiviral)Please note that new prices are in place as of 01 January, 2

https://www.stemcellcenter.lu.se/cellandgene/services - 2026-06-21

Förenta nationernas klimatpanel (IPCC) uppmuntrar till djup och snabb omvandling inom varje ekonomisk sektor för att förebygga eskalerande klimatförändringar. I detta sammanhang har en offentlig och politisk debatt om luftfart som en stor källa till koldioxidutsläpp uppstått i Sverige med ökande antal människor som förklarar att de ”håller sig på jorden”. Trots att forskning har undersökt motivatiThe Intergovernmental Panel on Climate Change is encouraging profound and rapid transformation in every economic sector to mitigate escalating climate change. In this context, a public and political debate about aviation as a high-carbon source has emerged in Sweden with growing numbers of people declaring that they are “staying on the ground”. Despite increased research that explores the motivati

Increased levels of the inflammatory mediator leukotriene D-4 (LTD4) are present at sites of inflammatory bowel disease, and such areas also exhibit an increased risk for subsequent cancer development. It is known that LTD4 affects the expression of many proteins that influence survival and proliferation of intestinal epithelial cells. We demonstrate here that after LTD4 exposure, beta-catenin tra

Follin C1, Gabery S2, Petersén Å2, Sundgren PC3, Björkman-Burtcher I3,4, Lätt J3, Mannfolk P3 and Erfurth EM1.1Department of Endocrinology, Skåne University hospital and IKVL, Lund University, Lund, Sweden.2Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Department of Diagnostic Radiology, Skåne University Hospital and IKVL/Lun

https://www.huntington-research.lu.se/associations-between-metabolic-risk-factors-and-hypothalamic-volume-childhood-leukemia-survivors - 2026-06-21

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2026-06-19