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We have earlier demonstrated that a Status Epilepticus (SE) during CNS development has long-lasting effects on cholinergic neurotransmission, detectable in vitro and in vivo. In this work, we aimed to localize changes in temporal (T) vs septal (S) hippocampus and to correlate adult CA3 interictal epileptiform discharge (IED) frequency changes to those of Ripples (R) and Fast Ripples (FR) of the Hi

Purpose: To explore stakeholders’ perceptions of the coordination of health and rehabilitation services for persons with disabilities in Sierra Leone. Materials and methods: A qualitative study including seven focus group discussions with health, rehabilitation, and disability organisations stakeholders in Sierra Leone. Content analysis was used for data analysis. Results: One theme emerged; poor

The main goal was to improve the longitudinal flying qualities by investigation of low stick forces and pitch-sensitivity of the ultralight aircraft, BW600-RG and to provide design suggestions for improvement. Computational fluid dynamics (CFD) was used to estimate stability derivatives and coefficients for calculation of the flying qualities derivate stick force gradient. Flight testing was condu

Polarization deficiency and excess ion hydration free energy at an electric field E (ion hydration free energy at the field E subtracted by the ion hydration free energy at zero field) of hydrated calcium, sodium, and chlori e ions have been determined by Monte Carlo simulations. A spherical cell containing either one ion and molecular water or only molecular water subjected to an external electri

OBJECTIVES: In this study, a systematic analysis was conducted of phasic intracoronary pressure and flow velocity in patients with severe aortic stenosis (AS) and coronary artery disease, undergoing transcatheter aortic valve replacement (TAVR), to determine how AS affects: 1) phasic coronary flow; 2) hyperemic coronary flow; and 3) the most common clinically used indices of coronary stenosis seve

The Cone Calorimeter is the most complete reaction-to fire test apparatus available presently. It measures heat release rates and mass loss rate, ignitability properties and smoke and toxic gas production rate. One of the main advantages remains in its wide spread and use. There are, however, some drawbacks in the cone calorimeter that should be noticed and maybe corrected for. The sample size is

Popular Abstract in Swedish Trumljud är det ljud som hörs i ett rum då ett objekt, till exempel en fot, träffar golvytan i samma rum. Ökande användning av tunna och hårda golvbeläggningar, såsom parkett och laminatgolv, kan leda till ljudstarka och skarpa ljud, vilket har ökat intresset av trumljud. En prediktionsmodell för den subjektiva responsen av trumljud vid en parvis jämförelse har tagits fDrum sound is the sound produced when an object, such as a foot, hits the flooring in the room in which the receiving ear is located. Drum sound has attracted interest in recent years, particularly due to an increased use of thin floating floor constructions, such as veneer or laminate flooring, which can produce loud and sharp walking sound. A prediction model of the subjective response, in a pai

The purpose of this project was to create a risk model for extended time between major overhauls on steam turbines. The project was created by Siemens Industrial Turbomachinery who develops and manufactures steam turbines and performs maintenance. It is the turbine users who have requested a longer time in order to reduce maintenance costs and increase availability. Prior to the work, external and

Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention.

Background: Use of bio-based diesel is increasing in Europe. It is currently produced from oilseed crops, but can also be generated from lignocellulosic biomass such as straw. However, removing straw affects soil organic carbon (SOC), with potential consequences for the climate impact of the biofuel. This study assessed the climate impacts and energy balance of biodiesel production from straw usin

As mass timber construction gains momentum worldwide, cross-laminated timber (CLT) has emerged as an important material in the built environment. However, the combustible nature of wood presents challenges and fire safety concerns, and a key interest with respect to CLT is the adhesive bond line. CLT is commonly used in ceiling configuration, and current fire stability evaluations rely predominant

BACKGROUND AND OBJECTIVE: The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) is evolving rapidly. Real-world data (RWD) are essential to understand actual treatment use and outcomes. This study aimed to describe treatment trajectories and clinical outcomes in a large, multicenter RWD cohort under the PIONEER project. METHODS: Eight European and US databases (2016-2020

Lifelong learning – upskilling your knowledge LUSEM has a long tradition of developing various forms of education for professionals and lifelong learning. In recent years, there has been an increased interest in returning to university after completing education, driven by the accelerating pace of digitisation in companies and organisations. This trend underscores the pressing demand for two key s

https://www.lusem.lu.se/study/education-professionals - 2026-04-29

The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin

Stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1), and proteoglycan fragments were quantified in knee synovial fluid samples in a cross-sectional study of patients who had injury to the anterior cruciate ligament or the meniscus. The average concentrations of stromelysin-1 and TIMP-1 increased 25-fold and 10-fold within the first day after the trauma, respectively, and the concentra

AIMS: The aim of this study was to determine the incidence of valve-related complications in patients with a mechanical aortic valve prosthesis and to identify risk factors for an adverse outcome.METHODS AND RESULTS: In the 424 patients, event-free survival rates 5 and 10 years after aortic valve replacement were 62% and 37%, respectively. The linearized incidence of thromboembolic events was 4.4%

For a train speed close to the speed of elastic waves in the soil, often referred to as “critical speed”, largely elevated vibration responses occur. This can be a practical problem for soft soil sites, where the phenomenon may cause excessive vibrations in the track and also at distances far from the track. To ensure the running safety of the train, the long-term quality of the track and to reduc