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Cu/Zn superoxide dismutase (SOD1) forms intracellular aggregates that are pathological indicators of amyotrophic lateral sclerosis. A large body of research indicates that the entry point to aggregate formation is a monomeric, metal-ion free (apo), and disulfide-reduced species. Fibril formation by SOD1 in vitro has typically been reported only for harsh solvent conditions or mechanical agitation.

Thyroid hormone level has been positively associatedwith breast cancer cell proliferation andtumour growth in experimental studies. However,previous observational studies have been contradictoryon the relationship between thyroidfunction and breast cancer. Age is a known riskfactor for breast cancer but its role as a prognosticfactor is less clear. The present thesis thereforeaimed to examine the

Aim: Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to Hb itself and to the surrounding proteins and lipids. However, the molecular mechanism underpinning Hp protection is to date unclear. The aim of this study was to use electron paramagnetic resonance (EPR) spectroscopy, stopped flow opt

Objective. To identify predictors as free-text markers for mental ill-health from an electronic perinatal record (EMR) system and the association with emergency cesarean section (CS) in nulliparous women. Material and methods. This was a population-based study using an EMR system, set in the catchment area of Malmö University Hospital in Sweden. Of 10 662 nulliparous women presenting with a single

Intra--arterial thrombolysis has become the most important minimal--invasive treatment option to treat acute lower limb ischemia. Although hemorrhagic stroke is a dreaded complication, it is considered beneficial to many fragile and elderly patients where vascular surgery is not an option. This review outlines current results after intra--arterial thrombolysis with low dose recombinant tissue plas

Protein stabilization was achieved through in vivo screening based on the thermodynamic linkage between protein folding and fragment complementation. The split GFP system was found suitable to derive protein variants with enhanced stability due to the correlation between effects of mutations on the stability of the intact chain and the effects of the same mutations on the affinity between fragment

Popular Abstract in Swedish Svensk sammanfattning Slaganfall (stroke), hjärtstillestånd eller överdosering av insulin är tillstånd som leder till en minskning av syre- och/eller glukos till hjärnvävnaden. Då tillförseln av glukos och syrgas minskar, kan cellerna inte längre upprätthålla en normal energiproduktion. Eftersom en stor del av energin går åt till bevara den spänning som finns över cellIn this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. The influence of bioenergetic failure on K+e concentration and Ca2+e homeostasis were also investigated in transient focal ischemia. Moreover, the free radical formati

Handledningsaritmetik Managing the politics of value creation – The case of waste management services Hervé Corvellec & Johan Hultman Department for service management Lund University Value in Service Management Service dominant logic has revived debate on value creation in services Emphasises shortcomings of value-in exchange view Co-creation of value e.g., Grönroos’ view that service provider an

https://www.ses.lu.se/sites/ses.lu.se/files/corvellec_servsig_2012_value_social_construct.ppt - 2026-05-01

Lead is a heavy metal which is toxic even at low exposure levels. Although the amount of lead used in industry is steadily declining, it still constitutes a common alloying element for most conventional brass varieties. Today, conventional brasses contain roughly 3 wt % lead. One of the main incentives for using lead as an alloying element is that it has a markedly positive effect on the machinabi

Gluten in bread can cause severe health problems in patients with celiac disease. However, gluten-free substitutions often show impaired quality characteristic like a liquid dough because of a missing gluten-network or accelerated staling due to the high amount of gluten-free starch. Therefore, hydrocolloids are considered to improve gluten-free bread quality characteristics. The idea of this degr

Lund University generates scientific knowledge that increases our understanding of problems related to sustainable development and examines potential solutions and the undesirable effects the solutions may cause. Research plays a crucial role in advancing the frontier of knowledge regarding sustainability issues. Sustainability is important for Lund University and top of the classSustainability sh

https://www.staff.lu.se/research-and-education/research-support/sustainable-development-research - 2026-05-02

Conference Full Paper template 4TH INTERNATIONAL CONFERENCE ON CRISIS COMMUNICATION IN THE 21ST CENTURY OCTOBER 7–10, 2015 IN HELSINGBORG, SWEDEN 1 Using the Riverside Situational Q-sort to Assess Perceptions of Hazard and Outrage Karen Freberg1, Sabrina Page2, Laura Freberg3, and Kristin Saling4 1 Communication, Strickler Hall 305B, University of Louisville, Louisville, KY 40292, Karen.freberg@lo

https://www.isk.lu.se/sites/isk.lu.se/files/karen_freberg.pdf - 2026-05-01

The Swedish retail landscape is currently undergoing a transformative change with increased digitalization and a rapidly growing e-commerce sector, which creates both opportunities and challenges. The development towards omnichannel commerce creates a more complex customer journey and results in complex environmental challenges. E-commerce deliveries to consumers, in particular, pose a complex soc

We consider the random normal matrix ensemble associated with a potential in the plane of sufficient growth near infinity. It is known that asymptotically as the order of the random matrix increases indefinitely, the eigenvalues approach a certain equilibrium density, given in terms of Frostman's solution to the minimum energy problem of weighted logarithmic potential theory. At a finer scale, we

Two C57BL/6 mice colonies maintained in two rooms of the same specific pathogen-free (SPF) facility were found to have different gut microbiota and a mucus phenotype that was specific for each colony. The thickness and growth of the colon mucus were similar in the two colonies. However, one colony had mucus that was impenetrable to bacteria or beads the size of bacteria - which is comparable to wh

Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

OBJECTIVE: Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-

Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known. To this end we sequenced bacterial 16S rRNA from fecal samples of Aβ precurso

Thromboembolic events are the second cause of death in cancer patients, although the mechanisms underlying this increased thromboembolic risk remain unclear. The aims of this study were to examine whether BRCA2 gene mutations may modify the circulating levels of thrombocoagulation biomarkers and whether breast cancer development may influence changes in such circulating biomarkers. The study was p