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Ncf1-Associated Reduced Oxidative Burst Promotes IL-33R+ T Cell-Mediated Adjuvant-Free Arthritis in Mice.

Reactive oxygen species (ROS) are important in the immune defense against invading pathogens, but they are also key molecules in the regulation of inflammatory reactions. Low levels of ROS production due to a polymorphism in the neutrophil cytosolic factor 1 (Ncf1) gene are associated with autoimmunity and arthritis severity in mouse models induced with adjuvant. We established an adjuvant-free ar

Patterns and dynamics of rest-phase hypothermia in wild and captive blue tits during winter.

We evaluated biotic and abiotic predictors of rest-phase hypothermia in wintering blue tits (Cyanistes caeruleus) and also assessed how food availability influences nightly thermoregulation. On any given night, captive blue tits (with unrestricted access to food) remained largely homeothermic, whereas free-ranging birds decreased their body temperature (T (b)) by about 5 degrees C. This was not an

Flow cytometric S-phase fraction in soft-tissue sarcoma: prognostic importance analysed in 160 patients

We could determine the S-phase fraction (SPF) by flow cytometric DNA analysis of paraffin archival material in 160 of 260 patients with soft-tissue sarcoma of extremity and trunk wall. The prognostic value of SPF was compared with other clinicopathological factors. The median follow-up time was 16 (6-31) years. In a univariate analysis, deep tumour location, increasing tumour size and histological

Soft-tissue sarcomas and exposure to chemical substances : A case-referent study

In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a case-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumor. A further case-referent study of soft-tissue s

Raman-shifted laser sources suitable for differential-absorption lidar measurements of ozone in the troposphere

Measurements have been performed at eight laboratories on Raman-shifted radiation from frequency-quadrupled Nd:YAG and KrF lasers. Each of these sources is a possible candidate for making differential-absorption lidar measurements of ozone in the free troposphere. The spectral purity, efficiency and divergence of the different sources are compared and explained using a simplified model of the Rama

Flexibility of exercise capacity during nestling feeding in blue tits

Nestling feeding in altricial birds is a physiologically demanding phase of the annual cycle. Accordingly, parental effort in breeding songbirds has been suggested to be limited by the maximum capacity to perform sustained aerobic work. However, the maximum capacity for exercise and plasticity thereof is understudied in free-living, breeding songbirds. We tested two predictions related to the plas

Platform For Strategic Work 2026–2027

Platform for Strategic Work | Lund University 2026–2027 Platform for Strategic Work LUND UNIVERSITY | 2026–2027 PLATFORM FOR STRATEGIC WORK | 2026–2027 2 Greater international impact, building upon strong local and regional engagement PLATFORM FOR STRATEGIC WORK 2026–2027 The world around us is significantly more unpredict­ able and changeable than before and the conditions are more complex. The f

https://www.staff.lu.se/sites/staff.lu.se/files/2026-04/Platform%20for%20Strategic%20Work%202026%E2%80%932027.pdf - 2026-05-05

Research centres and networks

The Department of Service Studies is part of several interdisciplinary research centers and networks. What characterizes these platforms is that they work as gathering points for researchers and practitioners, stimulating research and dialogue across boundaries – both within the academy and in the surrounding society. Centre for retail researchAn interdisciplinary centre of excellence in retail re

https://www.ses.lu.se/en/collaborate/research-centres-and-networks - 2026-05-05

Chemo-enzymatic epoxidation of linoleic acid: Parameters influencing the reaction

The effect of reaction parameters on lipase-mediated chemo-enzymatic epoxidation of linoleic acid was investigated. Hydrogen peroxide was found to have the most significant effect on the reaction rate and degree of epoxidation. Excess of hydrogen peroxide with respect to the amount of double bonds was necessary in order to yield total conversion within a short time period, as well as at temperatur

Induction of NFκB responses by the S100A9 protein is TLR4-dependent.

Interactions between danger and pathogen-associated molecular patterns (DAMP and PAMP) and pattern recognition receptors such as Toll-like receptors (TLRs) are critical for the regulation of the inflammatory process via activation of NFκB and cytokine secretion. In this report, we investigated the capacity of LPS-free S100A9 (DAMP) protein to activate human and mouse cells compared to lipoprotein-

The amyloid precursor protein(APP)of Alzheimer's disease and its paralog APLP2 modulate the Cu/Zn-NO-catalyzed degradation of glypican-1 heparan sulfate In vivo.

Processing of the recycling proteoglycan glypican-1 involves the release of its heparan sulfate chains by copper ion- and nitric oxide-catalyzed ascorbate-triggered autodegradation. The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains. We have investigated the possi

Surface-enhanced Raman scattering and fluorescence near metal nanoparticles

We present a general model study of surface-enhanced resonant Raman scattering and fluorescence, focusing on the interplay between electromagnetic (EM) effects and the molecular dynamics as treated by a density matrix calculation. The model molecule has two electronic levels, is affected by radiative and nonradiative damping mechanisms, and a Franck-Condon mechanism yields electron-vibration coupl

Correlation between membrane surface properties, polymer nature and fouling in skim milk ultrafiltration

The fouling of the membranes in skim milk ultrafiltration with the nominal molecular weight cut-off (MWCO) of 100 kDa fabricated from different polymers (polysulfone (PSF), polysulfonamide (PSA), aromatic polyamide (PA), polyacrylonitrile (PAN), cellulose acetate (CA) and regenerated cellulose (RC)) was studied. The membrane structure and physical-chemical properties of the selective layer were an

Car free urban districts – Interactions between measures, implementation and experience

Cities and car traffic does not always fit well together. Apart from the well-knownenvironmental problems associated with traffic congestion (e.g. air pollution and noise,climate change and global warming), there are also negative local effects in the form ofincreased risk of traffic accidents, abuse of key resources (energy and time), gender issues interms of accessibility, security and power ove

Sufficiency, change, and flexibility : Critically examining the energy consumption profiles of solar PV prosumers in Sweden

The number of consumers producing electricity at home, i.e., “prosumers”, is rapidly increasing in many European countries. This article analyses the electricity consumption and energy-saving behaviours of households that own photovoltaic (PV) systems in Sweden. Earlier studies of how home production of electricity affects consumption patterns are few and their results are mixed. We interviewed pr

A 9-Year Follow-Up of Women and Men Reporting Pain: Results from The Swedish National Study Of Aging And Care - Blekinge

Background and aim: Pain is common in older adults, but its relationship with ageing is unclear. The aim was toinvestigate pain among adults aged 72 years and older by means of a population-based sample followed for aperiod of nine years.Methods: The Swedish National study on Aging and Care (SNAC) is conducted at four research centres. AtSNAC-Blekinge (B), 609 (60.6%) women and 396 (39.4%) men wer

Effects of acetonitrile-water mixtures on α-chymotrypsin catalyzed dipeptide synthesis

α-Chymotrpysin (EC 3.4 21.1) was immobilized by deposition on celite and subsequent cross-linking with glutaraldehyde. The effects of different mixtures of aqueous buffer and acetonitrile on the immobilized preparation were evaluated using a dipeptide synthesis as model reaction. The initial reaction rate at 6-95% of water increased with increasing water content. The maximum yield of peptide had t

Ewing sarcoma of the mobile spine; predictive factors for survival, neurological function and local control. A Scandinavian sarcoma group study with a mean follow-up of 12 years

Object: Many patients with Ewing sarcoma (ES) of the mobile spine present with neurologic symptoms leading to emergency decompressive surgery. Only rarely is optimal treatment involving neo-adjuvant chemotherapy followed by en bloc excision possible. The purpose of this study was to study treatment, neurologic and oncologic outcome in patients with ES of the mobile spine. Methods: Twenty-four pati