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Induction of morphological changes in death-induced cancer cells monitored by holographic microscopy.

We are using the label-free technique of holographic microscopy to analyze cellular parameters including cell number, confluence, cellular volume and area directly in the cell culture environment. We show that death-induced cells can be distinguished from untreated counterparts by the use of holographic microscopy, and we demonstrate its capability for cell death assessment. Morphological analysis

pSTAT3 Expression is Increased in Advanced Prostate Cancer in Post-Initiation of Androgen Deprivation Therapy

Background: The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis and is involved in processes, such as proliferation, differentiation, drug resistance and immunosuppression. STAT3 can be activated by phosphorylation of tyrosine at position 705 (pSTAT3Tyr705) or serine at 727 (pSTAT3Ser727). High expression levels of pSTAT3 are implicate

Understanding the characteristics of non-equilibrium alternating current gliding arc discharge in a variety of gas mixtures (air, N2, Ar, Ar/O2, and Ar/CH4) at elevated pressures (1-5 atm)

This work aims at clarifying the fundamental mechanisms of non-equilibrium alternating current gliding arc discharge (GAD) by investigating effects of gas compositions and pressures on the GAD characteristics with electrical and optical methods. Interestingly, the glow-to-spark transition was found by adding O2 or CH4 into the argon or modulating the power supply. This transition occurs attributed

Phase-contrast computed tomography for quantification of structural changes in lungs of asthma mouse models of different severity

Lung imaging in mouse disease models is crucial for the assessment of the severity of airway disease but remains challenging due to the small size and the high porosity of the organ. Synchrotron inline free-propagation phase-contrast computed tomography (CT) with its intrinsic high soft-tissue contrast provides the necessary sensitivity and spatial resolution to analyse the mouse lung structure in

Dataset

Datasets published in an external, suitable repository should be added to LUCRIS. In LUCRIS, you register information about the dataset — not the dataset itself. Why should I add information about my datasets?It is voluntary for you as a researcher to add information in LUCRIS about the datasets you have created and how they can be accessed. Note that you do not upload the dataset itself in LUCRIS

https://www.staff.lu.se/research-and-education/research-support/lucris/use-lucris/dataset - 2026-05-06

Food diaries provide answers to researchers’ questions

Food can make us ill and it can make us healthy. “The current dietary recommendations are too general. Ideally, diets would be personalised for each individual, on the basis of a blood test taken at birth”, says Carin Andrén Aronsson, research dietician and head of unit at Skåne University Hospital. An important part of the faculty’s major population studies is to ask participants what they eat. F

https://www.medicine.lu.se/research-and-research-studies/meet-our-researchers/food-diaries-provide-answers-researchers-questions - 2026-05-05

Geo-mapping of time trends in childhood caries risk - a method for assessment of preventive care

Background: Dental caries is unevenly distributed within populations with a higher burden in low socio-economy groups. Several attempts have been made to allocate resources to those that need them the most; there is a need for convenient approaches to population-based monitoring of caries risk over time. The aim of this study was to develop the geo-map concept, addressing time trends in caries ris

New seeds for poor women? Reflections on the Multinational New Rice for Africa (Nerica) dissemination project in Sierra Leone

The introduction of new farming technologies, such as high-yielding varieties, has for long been regarded as one of the best strategies to increase agricultural production, and to combat poverty and food-insecurity. Since around 2005, New Rice for Africa (Nerica) is one of the main development strategies for combating such issues in Sierra Leone, and in many other African countries. Africa Rice Ce

Safety of thalidomide in newly diagnosed elderly myeloma patients: a meta-analysis of data from individual patients in six randomized trials

Treatment with melphalan-prednisone-thalidomide improves the outcome of patients with multiple myeloma and is now considered a standard of care for patients not eligible for transplantation. However, this treatment is a major source of morbidity. A meta-analysis of data from individual patients (n=1680) in six randomized trials was performed, comparing the effects of melphalan-prednisone-thalidomi

ADP regulation of insulin secretion and beta-cell apoptosis

Popular Abstract in Swedish Endokrina och metabola sjukdomstillstånd har många gemensamma komponenter. Att förstå de signalvägar som ligger till grund för dessa sjukdomar hjälper oss att utveckla bättre behandlingsmetoder. Det övergripande syftet med min forskning är att undersöka den roll s.k. G-protein kopplade receptorer spelar i endokrina metaboliska sjukdomar, mer specifikt de signalvägar somThe aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug

Automatic Reduction Procedures for Chemical Mechanisms in Reactive Systems

Popular Abstract in Swedish En av dagens största utmaningar är de stadigt ökande utsläppen av förorenande avgaser och drivhusgaser. Den största delen av dessa föroreningar kommer från förbränningsanläggningar och fordon. För att kunna minska utsläppen måste man förstå förbränningsprocesserna, och hur man kan kontrollera förbränningen. Utmaningen är att förbränningprocesser är mycket komplexa. Det To deal with complex physical and chemical processes in reactive systems, such as combustion processes, it is necessary to find methods that simplify modelling in such a way that it becomes both more comprehensible and practically useful. In the work reported here a method for automatically reducing chemical reaction mechanisms has been developed for use in computer simulations of various combusti

Course Call – Reflexive And Creative Methodology

Reflexive and Creative Methodology (7.5 credits) Organized by: Monika Müller 12–16 May, 2025 30 hours of lectures and seminars In principle, there are two major routes to producing credible research texts. One, indicating rationality, is to follow rules and procedures. The other is to journey competently and innovatively with the interpretive, political, linguistic, theory-data fused nature of the

https://www.ehl.lu.se/sites/ehl.lu.se/files/2025-03/Course%20call%20%E2%80%93%20Reflexive%20and%20Creative%20Methodology.pdf - 2026-05-06

Improve international symposium program

Microsoft Word - Dokument4 IMPROVE International Symposium 22-23 May 2014 Welcome to the final symposium of the IMPROVE- theme. The conference will bring together experts in human and animal vision to discuss various aspects relevant to how to IMPROve the Visual Environment for all. The Symposium will take place on May 22-23, 2014 at the Elite Hotel Ideon (Scheelevägen 27, 223 63 LUND). Lunch and

https://www.pi.lu.se/sites/pi.lu.se/files/improve_international_symposium_program.pdf - 2026-05-06

Trimethine Cyanine Dyes as NA-Sensitive Probes for Visualization of Cell Compartments in Fluorescence Microscopy

We propose symmetrical cationic trimethine cyanine dyes with β-substituents in the polymethine chain based on modified benzothiazole and benzoxazole heterocycles as probes for the detection and visualization of live and fixed cells by fluorescence microscopy. The spectral-luminescent properties of trimethine cyanines have been characterized for free dyes and in the presence of nucleic acids (NA) a

Assessment of numerical integration schemes and boundary conditions for Lagrangian tracking of marine debris

A growing environmental issue today is the amount plastic pollution in the ocean. To investigate how it might affect marine life, an important aspect is to study how plastics are transported by ocean currents and where it ends up. This can be done by use of Lagrangian simulation of plastic particles in computer ocean models. To improve the quality of the output from such simulations the number of

När vården krisar och juridiken paniker

Med hänvisning till den rådande resursbristen och till den ökade efterfrågan av vård i allmänhet och intensivvård i synnerhet är prioriteringsbeslut något som många vårdgivare måste befatta sig med dagligen. Under år 2020 när coronapandemin svepte över oss och belastade sjukvården ytterligare så blev frågeställningarna rörande prioriteringsbeslut ännu mer aktuella än innan. Socialstyrelsen släpptIn regard to the current shortage of resources and the increasing demand for care in general and intensive care in particular, priority decisions are something that many healthcare providers have to deal with on a daily basis. In 2020, as the Corona pandemic swept across us and further burdened the healthcare system, the issues surrounding priority decisions became even more relevant than before.

Postoperative complications following colonic resection for cancer are associated with impaired long-term survival

Aim: Surgery for colorectal cancer is associated with a high incidence of postoperative complications. The aim of this study was to analyse whether postoperative complications following radical resection for colorectal cancer are associated with increased recurrence rate and impaired survival. Method: Patients operated for colon cancer between 2007 and 2009 with curative intent were identified thr