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We review our recent work on the thermoseparating polymers in aqueous two-phase extractions of biomolecules. Random copolymers of ethylene oxide and propylene oxide (EOPO copolymers) are thermoseparating in water solution, i.e., at temperatures above the cloud point a concentrated copolymer phase and a water phase almost free of copolymer are formed. This phase behavior makes it possible to recycl

PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway,

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

Popular Abstract in Swedish Den här avhandlingens syfte var att undersöka hur väl barn kan återberätta en bevittnad händelse och vid behov identifiera en misstänkt gärningsman i en ”lineup”, en vittneskonfrontation där en misstänkt tillsammans med fem personer som liknar den misstänkte presenteras på fotografier. Tre studier genomfördes. Den första studien undersökte barns förmåga att återberätta Through centuries, witnesses to crimes have played an important role for the police to get a conviction of the culprit. This dissertation examined how accurate children are as witnesses of events and when participating in lineups. In Study 1, participants were tested with free recall and focussed questions. Children aged 8-9 years, 11-12 years and adults in two experiments witnessed film events

Looking back over 30 years of Swedish health care, professor Saltman examines structural changes in the Swedish health care sector. This is a very welcome contribution to the literature, and it makes good sense – institutional change is often a slow process, and it may take considerable time before the effects can be fully appreciated. Saltman’s paper provides a useful analytical overview of thre

Six-membered cyclic carbonates are potential monomers for phosgene and/or isocyanate free polycarbonates and polyurethanes via ring-opening polymerization. A two-step process for their synthesis comprising lipase-catalyzed transesterificationofa polyol, trimethylolpropane(TMP) with dimethylcarbonate(DMC)in a solvent-free system followed by thermal cyclization was optimized to improve process effic

This thesis investigates the evolving legal status of Sports Governing Bod-ies (SGBs) like UEFA and FIFA under EU law. It specifically questions whether their regulatory frameworks and practices align with EU competi-tion law and free movement principles. The research heavily relies on the analysis of recent pivotal court decisions, including the December Rulings and Diarra. The thesis begins by

Protein microarrays are powerful tools to quantify and characterize proteins in multiplex assays. They have great potential within clinical diagnostics and prognostics, as they minimize consumption of both analyte and biological sample. Assays that do not require labeling of the biological specimen, henceforth called label-free, are vital for ease of clinical sample processing. Here, we evaluate t

The expression of anti-predator adaptations may vary on a spatial scale, favouring traits that are advantageous in a given predation regime. Besides, evolution of different developmental strategies depends to a large extent on the grain of the environment and may result in locally canalized adaptations or, alternatively, the evolution of phenotypic plasticity as different predation regimes may var

Decarbonization policies require public support to be implemented and to remain in legislation. Examinations of public support for climate policies tend to focus on asmall number of policy instruments and/or use hypothetical instead of real policy proposals. Here, we address these criticisms by examining public support acrossfour distinct policy instruments– command-and-control, market-based, info

BACKGROUND: Recent years have seen enormous progress in the development of methods for modeling (bio)molecular systems. This has allowed for the simulation of ever larger and more complex systems. However, as such complexity increases, the requirements needed for these models to be accurate and physically meaningful become more and more difficult to fulfill. The use of simplified models to describ

Background Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age worldwide, caused by dysbiosis of the vaginal microbiome. Despite its prevalence, the underlying molecular mechanisms remain poorly understood, making diagnosis and treatment challenging. Although antibiotics are the standard therapy, recurrence rates are high, up to 50% within 1 year, and repe

This thesis contributes to the development of the proposed NNBAR experiment at theEuropean Spallation Source (ESS), which aims to search for free neutron-antineutron oscillations with unprecedented experimental sensitivity. Achieving this goal requires both an intense beam of cold neutrons and a detector capable of reconstructing the pionic final state expected from antineutron annihilation on a c

Migrating birds perform extreme endurance exercise when fly-ing. This shifts the balance between the production of reactive oxygen species and the antioxidant defense system toward the former, potentially generating oxidative damages. In between migratory flights, birds make stopovers, where besides accumulat-ing fuel (mainly fats), they are assumed to rest and recover from the strenuous flight. W

Material och produkter som kan innehålla hälsofarliga ämnen förekommer på förskolor i Hässleholms kommun. Bristande kunskap och rutiner bidrar även till barns exponering för dessa ämnen. Det är av vikt att man arbetar långsiktigt för giftfria förskolor. Åtgärder finns, och en hel del kan göras omgående för att minimera problemet. Användningen av kemikalier har ökat markant de senaste decennierna.During the last decades the production and consumption of chemicals has increased dramatically. We know that some chemicals are hazardous for humans and the environment but for most of them our knowledge is limited. Children are very sensitive to hazardous substances compared to adults because of their undeveloped bodies and different behavior. Due to lacking knowledge and regulation of chemicals

Patients with mild asthma may benefit from increasing their inhaled corticosteroid dose, adding a tong-acting beta(2)-agonist, or both. This study assessed the cost-effectiveness of these options. Patients aged greater than or equal to12 years with mild-to-moderate persistent asthma (n = 1272) were randomised to twice-daily, double-blind treatment with budesonide 100 mug, budesonide 100 mug plus f

Polymer-droplet interactions have been Studied in AOT/water/isooctane oil-continuous microemulsions mixed with an amphiphilic graft copolymer. or with the parent homopolymer (AOT = sodium bis(2-ethylhexyl) sulfosuccinate). The graft copolymer has an oil-soluble poly(dodecyl methacrylate) backbone and water-soluble poly(ethylene glycol) side chains. Pseudo-ternary polymer/droplet/isooctane phase di

Recent climate change predictions suggest altered patterns of winter precipitation across the Arctic. It has been suggested that the presence, timing and quantity of snow all affect microbial activity, thus influencing CO2 production in soil. In this study annual and seasonal emissions of CO2 were estimated in High-Arctic Adventdalen, Svalbard, and sub-Arctic Latnjajaure, Sweden, using a new trace

Over the past years fast label-free nonlinear imaging modalities providing molecular contrast of endogenous disease markers with subcellular spatial resolution have been emerged. However, applications of these imaging modalities in clinical settings are still at the very beginning. This is because single nonlinear imaging modalities such as second-harmonic generation (SHG) and two-photon excited f