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The expression of junD was studied in the rat hippocampus by in situ hybridization after 15 min of normothermic (37°C) and hypothermic (33°C) transient forebrain ischemia. Ischemia was induced by common carotid artery occlusion combined with hypotension leading to damage in the CA1 region of the hippocampus which was prevented by hypothermia junD mRNA was induced in the hippocampus within 2 h of r
Severe cerebral intraventricular hemorrhage (IVH) in preterm infants continues to be a major clinical problem, occurring in about 15-20% of very preterm infants. In contrast to other brain lesions the incidence of IVH has not been reduced over the last decade, but actually slightly increased. Currently over 50% of surviving infants develop post-hemorrhagic ventricular dilatation and about 35% deve
We have tried to calculate the free energy for the binding of six small ligands to two variants of the octa-acid deep cavitand host in the SAMPL5 blind challenge. We employed structures minimised with dispersion-corrected density-functional theory with small basis sets and energies were calculated using large basis sets. Solvation energies were calculated with continuum methods and thermostatistic
The need for dedicated fixtures for flexible manufacturing systems is increasing, as dedicated fixtures are lighter, more compact, and more accurate than flexible fixtures. The main challenges are that parts and processes are becoming more and more complex, which requires designing novel or complex dedicated fixtures, and that, for one given flexible fixture to be replaced, several variants of suc
The sharp rise in the incidence of Alzheimer's disease (AD) at an old age coincides with a reduction in energy metabolism and core body temperature. We found that the triple-transgenic mouse model of AD (3×Tg-AD) spontaneously develops a lower basal body temperature and is more vulnerable to a cold environment compared with age-matched controls. This was despite higher nonshivering thermogenic act
Abstract– Neural grafting has over the last decade emerged as a possible tool for the substitution of damaged neurons in the central nervous system and for the promotion of symptomatic recovery after brain damage. Transplantation studies in the 6‐hydroxydopamine lesion rat model of Parkinson's disease were initiated in the late seventies. The first studies were based on the neuronal replacement p
Spectroscopic studies of the reaction of [Os-3(CO)(11)MeCN)] with para-thiocresol to form [Os-3(mu-H)(CO)(10)(mu-SC6H4Me-p)] indicate that the reaction proceeds via a two-step consecutive process involving the intermediate [Os-3(CO)(11)-(MeC6H4SH-p)], in which there is an agostic Os-H-S interaction.
SynopsisOn the basis of kinetic studies of the manganese-catalyzed autoxidation of sulfite and thermodynamic data for iron−manganese redox processes and manganese(II) and -(III) protolysis equilibria, the catalytically active species in the autoxidation is concluded to be a mixed-valence oxo-bridged manganese(II,III) complex. Iron−manganese synergism and triggering of the chain reaction by small c
A four-week rehabilitation programme for back patients, focusing on functional activities and psychosocial factors in the demands of work and daily living, was evaluated. The programme is a combination of training of functional activities and increased psychological knowledge, body awareness and coping. A total of 40 patients with lumbago or lumbago ischias participated in the program and were com
Objective IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase- isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potenti
Wood is a hygroscopic material that absorbs and desorbs water to equilibrate to the ambient climate. Within material science, the moisture range from 0 to about 95-98% relative humidity is generally called the hygroscopic moisture range, while the exceeding moisture range is called the over-hygroscopic moisture range. For wood, the dominating mechanisms of moisture sorption are different in these
Visual cues provide an important means for aerial creatures to ascertain their self-motion through the environment. In many insects, including flies, moths, and bees, wide-field motion-sensitive neurons in the third optic ganglion are thought to underlie such motion encoding; however, these neurons can only respond robustly over limited speed ranges. The task is more complicated for some species o
Maximum urine concentration capacity was studied in healthy adults using different routes and doses of administration of 1-deamino-8-d-arginine vasopressin (DDAVP) - desmopressin. Plasma levels of DDAVP showed a dose-dependent increase after the subcutaneous but not after the intranasal administration. The effect on urine osmolality was similar but more prolonged after the subcutaneous as compared
This article considers the ways in which geo-political and legal concerns materialised in debates over self-determination in the years following decolonisation, and how they impacted on its’ possibilities, objectives and conception. During this period, self-determination was not, as some scholars have argued, a declining norm, but one central to the competing visions of reinventing international l
The development of the intraovarian adrenergic nervous system was investigated in the guinea-pig by use of chemical determination of catecholamines with high performance liquid chromatography (HPLC) and with the formaldehyde-induced fluorescence method for visualization of adrenergic nerves (Falck-Hillarp technique). Ovaries from fetuses (39-40, 45-50, 55-57, 60-63 days of gestation) and young ani
Aims/hypothesis: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of a
For many decades, Ingemar Ståhl was a well-known economist in Sweden. He introduced new perspectives into research, teaching and public debate. He made his presence felt in areas as diverse as housing policy, defense economics, energy policy, financial economics, industrial policy, higher education, union controlled wage earner funds, law and economics, health-care economics and taxation. He advoc
