Sökresultat

A hallmark of polycystic kidney diseases (PKDs) is aberrant proliferation, which leads to the formation and growth of renal cysts. Proliferation is mediated by cyclin-dependent kinases (Cdks), and the administration of roscovitine (a pan-Cdk inhibitor) attenuates renal cystic disease in juvenile cystic kidney (jck) mice. Cdk2 is a key regulator of cell proliferation, but its specific role in PKD r

This article closely analyses mutual recognition as a justification for EU legislative activity in the field of domestic criminal procedure. By looking at the structure, wording and purpose of the Treaties, the article first discusses the proper interpretation of the mutual recognition criterion in Article 82(2) TFEU. It argues for a narrow construction of Article 82(2) TFEU, suggesting that the e

This article presents a gendered analysis exploring publication productivity in the Philippines using bibliometric data from the Web of Science. It investigates the temporal pattern of journal article publications for six disciplines, its gendered distribution, differences between disciplines, patterns of authorship and collaboration, and how much women authors contribute and participate in resear

The de novo synthesis of the amino acid l-serine plays an essential role in the development and functioning of the central nervous system (CNS). l-Serine displays many metabolic functions during different developmental stages; among its functions providing precursors for amino acids, protein synthesis, nucleotide synthesis, neurotransmitter synthesis and l-serine derived lipids. Patients with cong

This article investigates the reception of Swedish broadside songs dealing with wonders and accidents from the seventeenth and eighteenth centuries. Focusing on rhetorical strategies, the study suggests that these broadside ballads were designed to function as the basis for Lutheran meditation. The wonders and accidents are interpreted as the divine words of God, and the shocking images are used t

Patients in an intensive care unit (ICU) may risk disruption of their circadian rhythm. In an intervention research project a cycled lighting system was set up in an ICU room to support patients' circadian rhythm. Part I aimed to compare experiences of the lighting environment in two rooms with different lighting environments by lighting experiences questionnaire. The results indicated differences

Barns internetanvändning äger i stor utsträckning rum i en kommersiell miljö där reklam och försäljning av virtuella föremål är ständigt närvarande. Genom att kombinera publikforskning, produktionsforskning samt textanalys (observationer online och dokumentanalys) bidrar denna avhandling till en kritisk förståelse av internet som en plats för barns vardagliga aktiviteter och deltagande, och som enChildren’s daily internet usage takes place to a large extent in a commercial environment, where advertising and the sale of virtual goods are ever-present parts of the online experience. The overall goal of this thesis is to contribute to a critical understanding of children’s commercial online environment as spaces for children’s everyday life activities and participation, and as spaces for comm

Arktiska miljöer har de senaste decennierna upplevt en stark temperaturökning, vilket påverkar tundrans kolcykel.Smältande permafrost, minskande snötäcke och förändringar i hydrologiska mönster är exempel på pågående processer som förändrar samspelet mellan mark och atmosfär samt ekosystemens säsongsdynamik.Då ett antal av dessa processer involverar utbyte av växthusgaser, såsom spårgaserna metan Arctic environments have experienced strong warming in recent decades, which is affecting the carbon cycle of tundra ecosystems.Degrading permafrost, diminishing snow cover, and changing hydrology are examples of ongoing processes that affect the land-atmosphere interactions and seasonal ecosystem dynamics.Since a number of the affected processes involve the exchange of atmospheric greenhouse gase

Changes in climate are likely to induce changes in precipitation characteristics including intensity, frequency, duration and patterns of events. In this paper, we evaluate the performance of multiple regional climate models (RCMs) in the North American Regional Climate Change Assessment Program (NARCCAP) to simulate storm properties including storm duration, inter-storm period, storm intensity, a

An extension of the available kinetic theory for reactions in the transient state is presented which establishes that single‐enzyme reactions may exhibit damped oscillations under the conditions of standard kinetic experiments performed by stopped‐flow techniques. Such oscillations may occur for reasonable magnitudes of rate constants in the enzymic reaction mechanism and at physiological concentr

Introduction: Thrombin generation tests (TGTs) are considered to give more detailed information of the overall coagulation capability of a patient than clotting-based routine assays. The TGT thrombin generation assay-calibrated automated thrombogram (TGA-CAT) uses both platelet-poor plasma (PPP) and platelet-rich plasma (PRP). Assessing PRP gives more physiological test conditions and is of great

Land-use and land-cover (LUC) changes are a key uncertainty when attributing changes in measured atmospheric CO2 concentration to its sinks and sources and must also be much better understood to determine the possibilities for land-based climate change mitigation, especially in the light of human demand on other land-based resources. On the spatial scale typically used in terrestrial ecosystem mod

This thesis employs an international comparative perspective to empirically analyse the Czech energy transition between 1830 and 2010. It addresses the utilization of energy in shaping modern economic growth through structural and technological change and the implications of those changes on specialization and foreign trade. New historical data is collected and utilized to investigate the impact o

Saccharomyces cerevisiae, the conventional baker's yeast, remains the most domesticated yeast monopolizing the baking industry. Its rapid consumption of sugars and production of CO2 are the most important attributes required to leaven the dough. New research attempts highlight that these attributes are not unique to S. cerevisiae, but also found in several non-conventional yeast species. A small n

Revised information on the morphology, chemistry and distribution of species of Parmelia s. str. in Fennoscandia is presented. Although Parmelia ernstiae was earlier believed to be chemically distinct from P. serrana in terms of lobaric acid, its presence in all studied samples detected by TLC means that these two semi-cryptic species can no longer be chemically separated. All three species are in