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Intracerebral neural transplantation offers a new strategy to combat Parkinson’s and Huntington’s diseases. However, a host immune response against a histoincompatible neural graft in the brain may jeopardize transplant survival. We transplanted dissociated mesencephalic tissue prepared from Sprague-Dawley (SD) (syngeneic), Lewis (allogeneic) rats or mice (xenogeneic), into 6-hydroxydopamine (6-OH
Protein S deficiency is an autosomal dominant trait affecting around 10% of families thrombophilic families. The high affinity interaction of approximately 60% of protein S with C4b -binding protein (C4BP) has raised a complicated situation for the diagnosis of deficiency states. Because only free protein S functions as cofactor in the protein C anticoagulant, it is important to measure free prote
Popular Abstract in Swedish Vid många industriella processer bildas olika typer av biprodukter, som kan vara mer eller mindre giftiga. En ovarsam hantering av de giftiga ämnena, eller en olycka, kan lätt leda till att den omgivande miljön blir förorenad. Förr, när man var mindre medveten om riskerna med de här ämnena hamnade de ofta i marken kring anläggningarna. Det har resulterat i många förorenBioremediation of soils is considered a low-cost alternative to other remediation techniques. Its ability to remove a number of different pollutants has been demonstrated, relying mainly on the activities of indigenous soil bacteria. The polycyclic aromatic hydrocarbons (PAHs) are considered major environmental pollutants in soil, some of them being toxic and others carcinogenic. Since high-molecu
Popular Abstract in Swedish Ökat antal patienter som lider av kärlsjukdomar behandlas idag med interventionella metoder istället för kirurgi. Dessa metoder populärt kallade ballong sprängningar, kombineras numera oftast med inläggande av ett metallnät (stent) som hjälper till med att förstärka kärlväggen, så den inte skall falla ihop efter ballong vidgningen. Oavsett vilken metod som används, kompBackground: Restenosis is the most frequently occurring adverse event after percutaneous intravascular treatment of atherosclerotic lesions, which limits long-term patency of the intervention. Objective: The aim of the study was to evaluate if minimizing vascular injury during treatment by insertion of self-expanding stents or modifying the reparative mechanisms by local drug delivery can reduce r
Populärvetenskaplig sammanfattning: Då man för ner en elektrisk ström i marken kommer vissa material i marken laddas upp p.g.a. att positiva och negativa joner samlar ihop sig på ytor och i trånga porkanaler. Detta kallas för polarisering och kan användas för att bestämma t.ex. vad för typ av geologiska material som finns under markytan eller vart föroreningar i marken tar vägen. Fenomenet som uppIt has been shown that surveys of Induced polarization (IP) often contain data of low quality, because it is highly sensitive against different noise sources. When measuring induced polarization, where the method uses multicore cables and continuous electrode sounding (CVES, Continuous Vertical Electrical Sounding), noise phenomena such as capacitive coupling effects have to be considered. It is p
Air sampling and biological sampling have been performed to examine the exposure to nicotine in the Nicorette patch and Nicorette gum production at Pfizer Health AB in Helsingborg, Sweden. For this purpose stationary and personal sampling equipment have been used. At the Nicorette patch production, XAD-2 tubes were used to sample nicotine vapor and at the Nicorette gum production Teflon filters we
The aim of this study was to examine the infiltration rate of water and some parameters affecting it. Especially the land usage, the abundance of roots and macropores were investigated. A field study was carried out on western Java in Indonesia, on the slope of Mount Salak. The study compared four different land uses; i.e. forest, shrub areas, tree plantation and cropland since there was a high o
Eastern New South Wales (NSW), Australia, is a region prone to frequent and intense droughts. An unprecedented episode of high temperatures and low rainfall in 2017–2019 culminating in the 2019-2020 summer triggered massive canopy dieback of eucalypt forests throughout the region. Subsequent high rainfall in 2020 offered a unique and rare opportunity to study the process of vegetation recovery fol
The breakup of the L-chondrite parent body (LCPB) in the asteroid belt at 466 Ma ago is the largest asteroid breakup documented in Earth's geological record for the past ca. three billion years. Recovery of abundant macroscopic fossil L chondrites in mid-Ordovician marine sediments as well as reconstructions of the flux of micrometeoritic chrome spinel through the ages have given much new informat
Importance: Meningioma is the most common subsequent neoplasm following cranial irradiation among survivors of childhood cancer, but there are still uncertainties regarding the magnitude of the radiation dose-response association, potential modifiers of radiation risks, and the role of chemotherapy. Objective: To evaluate meningioma risk in survivors of childhood cancer following radiotherapy and
IMPORTANCE Standard dosing of chemotherapy based on body surface area results in marked interpatient variation in pharmacokinetics, toxic effects, and efficacy.Whether tailored dosing can improve outcomes is unknown, as is the role of dose-dense adjuvant chemotherapy. OBJECTIVE To determine whether tailored dose-dense adjuvant chemotherapy improves the outcomes of early breast cancer compared with
The human-environment connection in the mostly rural drylands of sub-Saharan Africa forms a complex, interlinked system that provides ecosystem services. This system is susceptible to climatic variability that impacts the supply of its products, and high population growth, which impacts the demand for these products. When plants remove carbon dioxide from the atmosphere through the process of phot
En majoritet av de nordliga torvmarkerna utvecklades under holocen som ett resultat av en positiv massbalans mellan nettoprimärproduktion och heterotrofa nedbrytningshastigheter. Sedan dess har de lagrat stora mängder kol i terrestra ekosystem. En betydande del av dessa områden sammanfaller också med regioner med underliggande permafrost och uppvisar olika ackumulationsmönster av torv. Således, föThe majority of the northern peatlands developed during the Holocene as a result of a positive mass balance between net primary productivity (NPP) and heterotrophic decomposition rates. Over that time they have sequestered a huge amount of carbon in terrestrial ecosystems. A significant proportion of these areas also coincides with areas underlain with permafrost and shows a diverse range of peat
Popular Abstract in Swedish Oberoende av vilket bränsle som används ger förbränning upphov till utsläpp av miljöfarliga gaser, såsom kväveoxider, svaveldioxider, kolmonoxid och oförbrända kolväten. Dessa ämnen bidrar till försurning, smog, växthuseffekten och kan skada ozonlagret. Även koldioxid kan anses som en miljöfarlig gas då den bidrar till den globala uppvärmningen. För att få en bättre förIn the work presented in this thesis, different laser-based techniques were employed for measurements in different combustion devices. Laser-based techniques enable non-intrusive and in-situ measurements to be carried out, in which high spatial and temporal resolution can be obtained. Different parameters related to combustion research can be visualized, such as species concentrations, temperature
Semiconductor nanowires are studied by using transmission electron microscopy (TEM) based methods in this work. In the first section, the growth mechanism of gallium arsenide nanowires grown by chemical beam epitaxy is investigated. The nanowires are epitaxially grown from a gallium arsenide substrate by using gold seed particles as catalysts. The growth of gold particle catalysed nanowires is oft
Popular Abstract in Swedish Mag-tarmkanalen utgör kroppens största hormon-producerande organ. Många av de hormon-producerande cellernas funktion är ännu okänd och mycket lite är känt om den betydelse de kan ha vid olika sjukdomar i mag-tarmkanalen. I magsäckens syraproducerande del (fundus) finns 4 hormon-producerande celler, av vilka ECL cellen (65 %) och A-lika cellen (25 %) tillsammans utgör caThe ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. The first aim of the study was to prepare isolated ECL cells of high purity and to study and identify regul
This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i.e. pili, which recognize and bind to specific rec
Amelogenin is an extracellular matrix protein involved in formation of enamel during early tooth development. By interacting with the forming enamel crystallites amelogenin affects their growth, so that highly elongated hydroxyapatite crystals are formed. Early during the enamel formation amelogenin is proteolytically processed, which is essential for correct enamel formation. However, the exact m
The field of research dealing with the integration of biomolecules with electronic elements to form functional devices is called ‘‘bioelectronics’’. Bioelectronics based on mediated electron transfer (MET) between the biological element and the electrodes are designated as “second generation” while the one based on direct electron transfer (DET) is specified as “third generation”. Implanted bioele
Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non–muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatmen
