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Specific Derivatization of the Active Site Tyrosine in dUTPase Perturbs Ligand Binding to the Active Site

Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+protects against inactivation and modification, in agreement with the study onE. colidUTPase (Vertessyet al.(1994)Biochim. Biophys. Acta1205, 146-150). Amino acid analyses of nitrated dUTPases

Syllabi and reading lists

Autumn Semester 2023 Semester 1 SMMX11 Introduction to Service Management (7.5 credits)  Syllabus Reading list Examiner For specialisation Culture and Creativity Management SMMV12 Introduction to Culture and Creativity Management (7.5 credits)  Syllabus Reading list Examiner For specialisation Retail SMMV13 Introduction to Retail (7.5 credits) Syllabus Reading list Examiner For specialisation Supp

https://www.ses.lu.se/en/education/study-information/syllabi-and-reading-lists/syllabi-and-reading-lists-20 - 2026-05-27

Survival in cancer of unknown primary site: population-based analysis by site and histology

Cancer of unknown primary (CUP) is diagnosed at a metastatic stage, conferring an unfavorable prognosis. The natural history of the disease is poorly understood, which complicates diagnosis, treatment and follow-up. Population-based survival data are lacking regarding location and histology of metastases. From the Swedish Cancer Registry, 18 911 CUP patients were identified between years 1987 and

Multiscale Modeling of the Active Site of [Fe] Hydrogenase: The H-2 Binding Site in Open and Closed Protein Conformations

A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT+ and th

Mapping of the factor Xa-binding site on factor Va by site-directed mutagenesis.

Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be important for factor Xa binding. To further define which residues are important for factor Xa binding, we prepared fifteen recombinant factor V varia

Geological characterisation of geophysical lineaments as part of the expanded site descriptive model around the planned repository site for high-level nuclear waste, Forsmark, Sweden

Svenska Kärnbränslehanteringen (SKB) startade ett projekt under 2020 i närheten av Forsmark i Sverige med målet att utöka deformationszonsmodellen till att inkludera hela dräneringsområdet runt om det planerade slutförvaret för använt kärnbränsle. Detta arbete bygger på en lineamentmodell som var skapad för SKB. Denna modell använder sig av magnetiska data tillsammans med höjddata samt data insamlThe Swedish Nuclear Fuel and Waste Management Co. (SKB) started a project in 2020 near Forsmark, Sweden with the aim to expand the deformation zone model to encompass the entire catchment area around the planned repository for spent nuclear fuel. This thesis builds upon a lineament model that was constructed for SKB which utilizes airborne magnetic data supported by airborne Very Low Frequency (VL

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA

Mim jazz impro

Bachelor in Muisc symp orc inst Programme Syllabus 1 GENERAL INFORMATION 2 PROGRAMME DESCRIPTION 3 LEARNING OUTCOMES Knowledge and understanding - Skills and abilities - - - Judgement and approach - - 4 COURSE INFORMATION Master in Music Jazz Improvisation, Second cycle, 120 higher education credits Year 1 Year 2 Main field of study including an independent project of 30 higher education credits 2

https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/mim_jazz_impro.pdf - 2026-05-27

Rhesus monkey gastric mucins: oligomeric structure, glycoforms and Helicobacter pylori binding

Mucins isolated from the stomach of Rhesus monkey are oligomeric glycoproteins with a similar mass, density, glycoform profile and tissue localization as human MUC5AC and MUC6. Antibodies raised against the human mucins recognize those from monkey, which thus appear to be orthologous to those from human beings. Rhesus monkey muc5ac and muc6 are produced by the gastric-surface epithelium and glands

Jama prescott 2018 rv 170009

Enhancing Recovery From SepsisA Review Enhancing Recovery From Sepsis A Review Hallie C. Prescott, MD, MSc; Derek C. Angus, MD, MPH IMPORTANCE Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery. OBSERVATIONS Each year, more than 19 mil

https://www.sepsis.lu.se/sites/sepsis.lu.se/files/jama_prescott_2018_rv_170009.pdf - 2026-05-27

Countercurrent Distribution of Lymphocytes from Human Peripheral Blood in an Aqueous Two-Phase System : I. Separation into Subsets of Lymphocytes Bearing Distinctive Markers’

Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o

No title

The present study examines in a quantitative manner the relationship between the attitudes toward gender equality and those toward gender-inclusive language. It also studies how a text written with gender-inclusive language is evaluated and observes what factors can act thereupon. Firstly, statistical analyses show that women have more positive attitudes than men, and that residents in a French-sp

Antibody-dependent allostery of the M1 protein

Den förrädiska antikroppen Streptokocker är en lömsk bakterie som har många olika sätt att ta sig runt vårt immunförsvar. Den kan låtsas vara en del av vår kropp genom att klä sig själv i en proteinkapsel som är väldigt likt ett mänskligt protein, bryta ned våra celler med hjälp av utsöndrade gifter och använda vårt immunförsvar mot oss genom att binda antikroppar till sig själv. En virulensfaktoThe Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands