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Crystal structure of β-glucosidase 1A from Thermotoga neapolitana and comparison of active site mutants for hydrolysis of flavonoid glucosides

The β-glucosidase TnBgl1A catalyses hydrolysis of O-linked terminal β-glycosidic bonds at the nonreducing end of glycosides/oligosaccharides. Enzymes with this specificity have potential in lignocellulose conversion (degrading cellobiose to glucose) and conversion of bioactive flavonoids (modification of glycosylation results in modulation of bioavailability). Previous work has shown TnBgl1A to hy

EUCAARI ion spectrometer measurements at 12 European sites - analysis of new particle formation events

We present comprehensive results on continuous atmospheric cluster and particle measurements in the size range similar to 1-42 nm within the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. We focused on characterizing the spatial and temporal variation of new particle formation events and relevant particle formation parameters across Europe. Dif

An exploratory study of Middle Stone Age and Later Stone Age site locations in Kenya’s Central Rift Valley using landscape analysis : a GIS approach

The Kenyan central rift has witnessed dramatic climatic changes over relatively short periods of time in response to global climatic changes, with the water levels of the lakes within the rift rising and falling with these changing conditions. There is considerable evidence showing extreme wet and dry phases throughout their existence. These wet and dry phases also influenced the vegetation cover,

Site localisation on bacterial surface proteins using super resolution imaging

I snart 500 år har människan använt sig av diverse optiska instrument för att betrakta sådant som inte är möjligt att se med blotta ögat. Teleskop har använts för att studera himlakroppar och mikroskop för att exempelvis undersöka små biologiska beståndsdelar. Det finns idag många olika metoder inom optisk mikroskopi men samtliga följer en liknande grundprincip. Objektet som ska avbildas exponerasSeveral significant pathogenic bacteria exhibit surface proteins that bind human antibodies, preventing them from being recognized by the human immune system. These bacteria are thus protected from elimination and can survive in the host organism. One common such bacteria is the Streptococcus pyogenes that exhibits the antibody binding M protein on its surface. Streptococcus pyogenes causes more t

Regulation of HPV16 splice sites located in the E6/E7 oncogene coding region

Kan cellers proteiner bota HPV- sjukdomar? Livmoderhalscancer är en av de vanligaste cancersjukdomarna som drabbar kvinnor världen över. Varje år, diagnostiseras ungefär 500 000 kvinnor och 270 000 dör i sjukdomen, varav de flesta dödsfallen sker i utvecklingsländer. Livmoderhalscancer orsakas av det vanligt förekommande viruset humant papillomvirus (HPV) och för att hitta bättre behandling mot sHuman papillomaviruses (HPVs) are small DNA viruses that have evolved over millions of years and are well-adapted to humans. Persistent infections with HPVs, can result in cancer development. There are over 200 different HPV types that can be divided into high- and low risk types based on their ability to cause cancer. HPV16 is the most common high- risk type that accounts for more than 50 % of al

Finding potential sites for small-scale hydro power in Uganda : a step to assist the rural electrification by the use of GIS : a minor field study

Populärvetenskaplig sammanfattning: Mer än två miljarder människor, mestadels i utvecklingsländer, saknar tillgång till moderna energikällor eller elektricitet. Behovet av rena, effektiva, pålitliga och ekonomiskt överkomliga energitjänster är en viktig fråga i utvecklingsländer, särskilt för landsbygden, där merparten av befolkningen bor. Förnyelsebara energikällor i form av småskaliga vattenkrafOver 2 billion people, mostly in developing countries, have no access to modern fuels or electricity. The necessity of clean, efficient, reliable and affordable energy services is a crucial issue in developing countries, especially in the context of rural areas where the majority of the people lives. Renewable energy sources in shape of small-scale hydropower systems are a complement or alternativ