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BACKGROUND: According to the World Health Organization (WHO) the cost of adverse drug reactions (ADRs) in the general population is high and under-reporting by health professionals is a well-recognized problem. Another way to increase ADR reporting is to let the consumers themselves report directly to the authorities. In Sweden it is mandatory for prescribers to report serious ADRs to the Medical

ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

Global carbon balances are increasingly affected by large fluctuations in productivity occurring throughout semiarid regions. Recent analyses found a large C uptake anomaly in 2011 in arid and semiarid regions of the southern hemisphere. Consequently, we compared C and water fluxes of two distinct woody ecosystems (a Mulga (Acacia) woodland and a Corymbia savanna) between August 2012 and August 20

Human malignancies are often hallmarked with genomic instability, which itself is also considered a causative event in malignant transformation. Genomic instability may manifest itself as genetic changes in the nucleotide sequence of DNA, or as structural or numerical changes of chromosomes. Unrepaired or insufficiently repaired DNA double-strand breaks, as well as telomere shortening, are importa

Climate change can lead to an increased frequency of extreme weather events, which may induce a decline in tree vitality, rendering the forest more vulnerable to other stress factors. In this study we used the ecosystem model LPJ-GUESS to compare the NPP of boreal conifers on till soil and sandy soil, simulating the growth of Norway spruce during the 21st century using climate model projections co

BACKGROUND: Multisite pain and obesity are cross-sectionally related and are common conditions that may influence each other through socio-demographic, lifestyle and/or health-related factors. The aim of the present study was to examine the cross-sectional and prospective associations between overweight/obesity and multisite pain in a general population.METHODS: In a 20-year population-based prosp

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N ¼ 1,595) were used to build genetic models to predic

Previous studies have shown the beneficial effects of the hepatocyte growth factor (HGF) gene on myocardial perfusion and infarction size but not on the regional strain in relationship to global left ventricular function. A noninvasive magnetic resonance (MR) study was performed to determine the effect of a new HGF gene, VM202, expressing two isoforms of HGF, on regional and global left ventricula

The occurrence of an early Preboreal climatic cooling/oscillation (PBO) in lacustrine and glacial records from northwest Europe, Iceland and Greenland is reviewed and documented. The often subtle response of the proxy records to this oscillation, in combination with its short duration, make it difficult to detect. Owing to its chronostratigraphic position between the 10000-9900 and 9600-9500 14C p

Parkinson’s disease is characterized by a progressive loss of substantia nigra (SN) dopaminergic neurons and the formation of Lewy bodies containing accumulated alpha-synuclein (α-syn). The pathology of Parkinson’s disease is associated with neuroinflammatory microglial activation, which may contribute to the ongoing neurodegeneration. This study investigates the in vivo microglial and dopaminergi

The development of migratory behaviour is a continuous process which is not only determined by genes, but also moulded by individual differences based on life-history variations occurring at each ontogenetic stage. Assessing consistency and plasticity in migratory traits between long distance (LDM) and short distance migratory (SDM) populations within the same species that may express dissimilarit

Field observations of new particle formation and the subsequent particle growth are typically only possible at a fixed measurement location, and hence do not follow the temporal evolution of an air parcel in a Lagrangian sense. Standard analysis for determining formation and growth rates requires that the time-dependent formation rate and growth rate of the particles are spatially invariant; air p

Family history (FH) of cancer is an important factor of increased risk of several cancers. Although the association between FH of cancer and concordant cancer risk has been reported in many previous epidemiological studies, no comprehensive prospective study with adjustment for lifestyle habits has evaluated the association of FH of cancer and concordant cancer risk. We investigated the associatio

Si fluxes from the continents to the ocean are a key element of the global Si cycle. Due to the ability of coastal ecosystems to process and retain Si, the ‘coastal filter’ has the potential to alter Si fluxes at a global scale. Coastal zones are diverse systems, sensitive to local environmental changes, where Si cycling is currently poorly understood. Here, we present the first palaeoenvironmenta

Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proTo date, bone marrow-derived mesenchymal stromal cells (MSCs) have been considered the golden standard among MSC cell-based therapies. However, the harvesting of bone marrow is a highly invasive procedure and the number of MSCs isolated is low, and it declines with increasing age. MSCs with immune-regulatory and regenerative properties can be isolated from many different tissues; however, bone mar