Filtyp
Proton-transfer dynamics plays a critical role in many biochemical processes, such as proton pumping across membranes and enzyme catalysis. The large majority of enzymes utilize acid-base catalysis and proton-transfer mechanisms, where the rates of proton transfer can be rate limiting for the overall reaction. However, measurement of proton-exchange kinetics for individual side-chain carboxyl grou
Holocene records of cellulose-inferred lake-water delta O-8 were produced from two lake-sediment sequences obtained in central and northern Kamchatka, Russian Far East. The sediment records share similar fluctuations in delta O-8 during the interval of ca. 5000-800 cal yr BP that correspond (inversely) with changes in K+ content of the GISP2 ice-core record from Greenland, a proxy for the relative
Background Both patient survival and the proportion of patients diagnosed with thin cutaneous malignant melanoma (CMM) have been steadily rising in Sweden as in most Western countries, although the rate of improvement in survival appears to have declined in Sweden at the end of the last millennium. Objectives To analyse the most recent trends in the distribution of tumour thickness (T category) as
Cell abundances and distributions of Alexandrium catenella resting cysts in recent sediments were studied along time at two locations in the Chilean Inland Sea exposed to different oceanographic conditions: Low Bay, which is much more open to the ocean than the more interior and protected Ovalada Island. The bloom began in interior areas but maximum cyst concentrations were recorded in locations m
The standard setup for single-file diffusion is diffusing particles in one dimension which cannot overtake each other, where the dynamics of a tracer (tagged) particle is of main interest. In this article, we generalize this system and investigate first-passage properties of a tracer particle when flanked by identical crowder particles which may, besides diffuse, unbind (rebind) from (to) the one-
We describe the implementation of a biochemical model of isoprene emission that depends on the electron requirement for isoprene synthesis into the Farquhar-Ball-Berry leaf model of photosynthesis and stomatal conductance that is embedded within a global chemistry-climate simulation framework. The isoprene production is calculated as a function of electron transport-limited photosynthesis, interce
The Gram-positive bacterium Streptococcus pneumoniae is a major human pathogen that causes infections ranging from acute otitis media to life-threatening invasive disease. Pneumococci have evolved several strategies to circumvent the host immune response, in particular the complement attack. The pneumococcal glycolytic enzyme phosphoglycerate kinase (PGK) is both secreted and bound to the bacteria
One group of commonly found parasites in birds, for which fitness consequences and effects on life history traits have been much debated are Haemosporidian blood parasites. In a long term study population of great reed warblers Acrocephalus arundinaceus in Sweden, previous studies have shown that the Haemosporidian blood parasites are in their chronic phase during the breeding season and that the
We examined the transduction efficiency of different adeno-associated virus (AAV) capsid serotypes encoding for green fluorescent protein (GFP) flanked by AAV2 inverted terminal repeats in the nonhuman primate basal ganglia as a prelude to translational studies, as well as clinical trials in patients with Parkinson's disease (PD). Six intact young adult cynomolgus monkeys received a single 10 mu l
ad är ett folkhälsoproblem och vilka olika folkhälsoproblem har präglat mänsklighetens historia? Hur har Hippokrates läror påverkat dagens syn på folkhälsoarbete, och var i historien uppträder karantän som en folkhälsoåtgärd för första gången? Denna bok försöker inte bara att besvara dessa frågor, utan även förklara vad folkhälsovetenskap är samt berätta om folkhälsoarbetets historia. Boken är upp
Popular Abstract in Swedish Olika sätt att mäta substrat (monosackarider) och produkter (främst etanol) vid tillverkning av biobränslet etanol har studerats. Etanoltillverkning sker i en fermentor med hjälp av mikroorganismer som kan omvandla socker. Det är av stort intresse att mäta koncentrationen av produkter och substrat under tillverkningsprocessens gång för att veta om den fortlöper som den Two different detection methods for on-line monitoring of substrates and products in ethanol fermentations have been studied. Amperometric biosensors were developed for use as detectors in flow injection or liquid chromatographic (LC) systems. Carbon paste was used as the electrode material and served as the supporting matrix to incorporate the enzymes alcohol oxidase or pyranose oxidase. Hydrogen
Popular Abstract in Swedish Urininkontinens utgör ett stort socialt problem, framför allt hos den äldre befolkningen. Kliniskt är urininkontinens iakttaget i större omfattning hos kvinnor än hos män, men studier antyder männen är mer drabbade än vad nuvarande statistik gör gällande. Grundat på symptombild kan urininkontinens indelas i trängningsinkontinens, ansträngningsinkontinens samt överrinninNormal urine storage and bladder emptying are controlled by the central (CNS) as well as the peripheral nervous system. Dysfunction of these mechanisms can lead to urinary incontinence. Urinary tract dysfunctions have symptomatically been treated mainly with drugs acting peripherally. However, in the CNS, drug targets for pharmacological intervention may be found. The present study deals with effe
An ability to interact with plasminogen or plasmin could provide micro-organisms with a mechanism for invasion. Thus, group A, C and G streptococci secrete streptokinase which binds and activates plasminogen. Some streptococci also express surface structures which bind plasminogen without causing its activation. Plasminogen-binding surface proteins were extracted from one group C and one group G s
The aim of this study is to generate a quality-controlled sub-kilometer dataset of the fraction of absorbed photosynthetically active radiation (FAPAR) across Scandinavia from satellite. FAPAR is required for estimating the amount of PAR absorbed (APAR) by vegetation, which in turn allows for estimation of carbon uptake. In this study, FA-PAR was modeled from normalized difference vegetation index
Syftet var att undersöka upplevelsen av vad som påverkat måendet hos sju unga vuxna med självrapporterad erfarenhet av självskadebeteende. Urvalet har skett i en grupp som tidigare varit med i en enkätstudie vid tre tillfällen och vid något av dessa tillfällen rapporterat självskadebeteenden. Semistrukturerade intervjuer analyserades med tematisk analys. Resultaten visade att deltagarna upplever eThe aim of this study was to investigate the experience of what impacts well-being in seven young adults with self-reported experience of self-harm. The participants have previously participated in a survey-based study and reported self-harm at some point. Semi-structured interviews were analysed using thematic analysis. The results suggested that participants experience an external influence on t
Swedish law provides robust protection for both children and employees. However, legal uncertainty arises when a parent is placed in a residential care home (HVB) together with their child. In such cases, there is currently no specific regulation clarifying the parent’s right to take leave from work or receive financial compensation, even though the absence is based on an official decision grounde
This thesis investigates the climate impact of a newly constructed residential complex in Oceanhamnen, Helsingborg, through an extended life cycle assessment (LCA) covering both building and non-building elements such as road infrastructure, inner courtyards, external installations, that area often overlooked in conventional assessments. The aim is to develop a replicable method to quantify the gl
