Filtyp
Two-dimensional (2D) buried delta-function-shaped Sb-doping profiles have been obtained in Si using a low-energy accelerated Sb-ion source during molecular-beam epitaxy. A combination of secondary-ion mass spectrometry (SIMS), capacitance-voltage (C-V) measurements, and cross-sectional transmission electron microscopy (XTEM) was used to investigate dopant distributions and to determine profile wid
Objectives: : Knowledge of the correspondence between clinical ICD diagnoses and classification criteria fulfilment is crucial to interpret studies identifying cases via ICD codes. We assessed the degree to which patients registered with ICD-10 diagnoses of psoriatic arthritis (PsA) in the Swedish National Patient Register (NPR) fulfil established PsA classification criteria. Method: Four hundred
Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or granules and can therefore only be used for extracellular drug release. This shortcoming could be overcome with the use of cell penetrating HA nan
The MAM blood group system (International Society of Blood Transfusion [ISBT] 041) consists of one high-prevalence antigen to date, first detected in a 31-year-old woman during her third pregnancy. Epithelial membrane protein 3 (EMP3) was recently identified as the gene coding the MAM antigen. Six unique genetic variants have been described in EMP3 in 11 MAM- individuals. EMP3 is an 18-kDa glycopr
In the pulp and paper industry, about 5 Mt/y chemithermomechanical pulp (CTMP) are produced globally from softwood chips for production of carton board grades. For tailor making CTMP for this purpose, wood chips are impregnated with aqueous sodium sulphite for sulphonation of the wood lignin. When lignin is sulphonated, the defibration of wood into pulp becomes more selective, resulting in enhance
In situ stability studies of an IrO2(110)-TiO2(110) model electrode are carried out under acidic water electrolysis conditions, employing synchrotron-based techniques including surface X-ray diffraction (SXRD) and X-ray reflectometry (XRR) with a photon energy of 21.5 keV. These experiments are complemented by ex situ scanning electron microscopy (SEM), scanning tunneling microscopy (STM), and X-r
Pro-inflammatory and amyloidogenic S100A9 protein is central to the amyloid-neuroinflammatory cascade in neurodegenerative diseases. Polyoxometalates (POMs) constitute a diverse group of nanomaterials, which showed potency in amyloid inhibition. Here, we have demonstrated that two selected nanosized niobium POMs, Nb10 and TiNb9, can act as potent inhibitors of S100A9 amyloid assembly. Kinetics ana
Co-design processes are of key importance in planning and implementing Nature-based Solutions (NBS), but require boundary management between diverse holders of local, practical and scientific knowledge. Participatory and mapbased planning tools, such as Geodesign workshops, can facilitate such boundary management through mobilising knowledge holders, and translating and negotiating between differe
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs. Aims: To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when comp
BACKGROUND: Triage is used as standard of care for prioritization and identification of time-critical patients in the emergency department (ED) globally, but it is unclear what outcomes should be used to evaluate triage. Currently used outcomes do not include important time-critical diagnoses and conditions.METHOD: We used 18 Swedish triage experts to collect and assess outcomes for the evaluation
This paper investigates how stakeholders respond to digital feasibility study images to augmented reality (AR), with the purpose to determine if AR could be the right practical application to create Virtual tourism. Based on the visitors’ perspective via qualitative interviews, the goal is to explore whether a digitalization in a realistic way, manages to mediate the concealed time layers and othe
Peatlands are unique ecosystems that contain massive amounts of carbon. These ecosystems are incredibly vulnerable to human disturbance and climate change. This may cause the peatland carbon sink to shift to a carbon source. A change in the carbon storage of peatlands may result in surface deformation. This research uses the interferometric synthetic aperture radar (InSAR) technique to measure the
MUC5B is the predominant glycoprotein in saliva and is instrumental in the establishment and maintenance of multi-species eubiotic biofilms in the oral cavity. Investigations of the aciduric Lactobacillaceae family, and its role in biofilms emphasizes the diversity across different genera of the proteolytic systems involved in the nutritional utilization of mucins. We have characterized a protease
Treatment of chronic osteomyelitis by radical debridement and filling of the dead space with antibiotic containing calcium sulphate/hydroxyapatite (CaS/HA) bone substitute has shown excellent long-term outcomes. However, in extensive infections, sessile bacteria may remain in bone cells or soft tissues protected by biofilm leading to recurrences. The primary aim of this study was to evaluate if sy
Sedan mitten på 1900 talet har halvledarmaterial revolutionerat hur vi ser på världen genom uppfinningar som det har gett upphov till, såsom datorer, solceller, och lysdioder. Det är möjligheten att kunna styra halvledarens förmåga att leda ström—mellan att vara nästan metallisk till att vara isolerande—som gör den användbar för tillämpningar inom elektronik. Under de senaste decennierna har elektThis dissertation focus on the atomic-scale characterization of the surface properties and electronic structure of III–V semiconductor nanowires (NWs). Since the early 2000s, the fabrication and characterization of III–V NWs has been a very significant topic within material science due to their potential for applications in lighting, energy harvesting, and electronics. A prominent feature of the N
CONTEXT: Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results.OBJECTIVE: To generate large-scale evidence on whether 3 common ESR1 polymorphisms (intron 1 pol
Peak bone mass is an important risk factor for the development of osteoporosis in later life. Previous work has suggested that genetic, intrauterine, and environmental factors all contribute to the regulation of bone mass, but the ways in which they interact with each other to do so remain poorly understood. In this study, we investigated the relationship between peak bone mass and polymorphisms o
Background: Type 2 diabetes (T2D) is a complex disease characterised by chronic hyperglycaemia. The effects of elevated glucose on global gene expression in combination with DNA methylation patterns have not yet been studied in human pancreatic islets. Our aim was to study the impact of 48 h exposure to high (19 mM) versus control (5.6 mM) glucose levels on glucose-stimulated insulin secretion, ge
A commercially available NaI(Tl) based spectrometer-dosimeter has been used to separate contributions of the terrestrial radionuclides (238U series, 232Th series and 40K) and 137Cs to the total ambient dose equivalent rate (ADER), Ḣ*(10) , outdoors. The device had been initially calibrated by the manufacturer to measure: 1) the total ADER; 2) activity concentrations of 226Ra, 232Th, 40K and ‘effec
