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Head and neck squamous cell carcinoma (HNSCC) is a heterogenous cancer with poor prognosis, especially for patients with advanced or recurrent disease. The complex tumor microenvironment (TME) plays an important role in mediating immune evasion and therapy resistance. To improve preclinical testing, advanced 3D in vitro and ex vivo models such as spheroids, organoids, and tumor slice cultures have

3,5 miljarder år gamla bakterier kan rädda våra vatten från metallutsläpp Långt innan det fanns syre i atmosfären så fanns bakterier som ”andades” svavel. I stället för att andas ut koldioxid andas dessa bakterier ut sulfid, en negativt laddad svaveljon som binder till metaller. På en avfallsanläggning utanför Hässleholm står en testanläggning där man forskar på att minska utsläppen av metaller t

In today's world, it is essential to understand how customer in-store experiences can be successfully transferred to online environments for international jewelry retailers to master their digital transformation. Further, there is an apparent lack of extensive research about the jewelry retailing industry and its customers in academia despite its prominence in the business world. Therefore, th

Rumour refutation is a series of campaigns that the Chinese authorities invest in combating 'the overflow' of network rumours, especially since 2017. These campaigns reflect the Chinese's knowledge of rumour as false and harmful. Among which #PoliceRefuteRumours on social media platform Weibo is one of the most typical forms conducted most explicitly and exposed problematically. Throug

Sustainable development at the local level is greatly impacted by policymaking. In China’s Jingmai Mountain region, the sustainable development policies are centred mostly around the tea industry, due to the social and environmental dynamics surrounding tea in that region. However, considering the complex interlinkages between the tea industry and local environment and society, the policies concer

Traumatic brain injury (TBI) is a common cause of morbidity and mortality in young individuals. Following TBI, the initial injury caused by the head impact is exacerbated by a complex cascade of secondary injury factors leading to increased tissue loss. TBI is an established risk factor for neurodegenerative disorders including Alzheimer disease (AD). In long-term survivors of TBI, increased aggre

Populärvetenskaplig sammanfattning av examensarbete utfört vid institutionen för byggvetenskaper vid LTH i samarbete med Sweco Civil AB. Under vissa förhållanden kan sugkrafter uppstå i jord. Fenomenet är sammankopplat med hur mycket vatten det finns i marken, desto mindre vatten desto högre sugkraft och därmed mindre risk för att t.ex. jordslänter rasar. För att undersöka detta fenomen har finiIn this master´s dissertation I investigated if it is possible to increase the total stability for excavations in clay, if suction is taken into account during the calculations. The work has been performed at, and in cooperation with, Sweco Civil AB as well as the Dept. of Construction Sciences at Faculty of Engineering LTH, Lund University. The objective of this master´s dissertation is to asse

Bostadsbristen slår hårdast mot dem som redan står längst ifrån bostadsmarknaden. Unga, nysvenskar och äldre har fått det svårare att få sina bostadsbehov tillgodosedda. Det svenska bostadsbyggandet har sedan år 2006 varit lågt i förhållande till befolkningsutvecklingen (Boverket 2015:a). Effekterna av ett lågt bostadsbyggande är bland annat en ökad trångboddhet, osäkra boendeförhållanden, svarthaThe effects of a housing shortage will be hardest on those groups, who are far from being a part of the housing market. It is becoming more and more difficult for young adults, immigrants and elderly to find a solution for their housing needs in Sweden. Since 2006, the rate of construction of housing in Sweden has been relatively low compared to the population growth rate (Boverket 2015:a). The ef

Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 diabetes (T2D) in humans. Here we analyzed mRNA expression and DNA methylation of PDX-1 in human pancr

Popular Abstract in Swedish Mikroorganismer finns överallt! De klarar av att överleva i extrema miljöer, extrema pH, extrema temperaturer och kan motstå strålning och gift i doser som vi inte skulle överleva. Framförallt klarar mikroorganismer av att överleva i en specifik extrem miljö - människan. Hundratals olika mikroorganismer bor på och i oss, i ett antal som långt överskrider vårt eget cellaMicroorganisms are everywhere! They can tolerate many diverse extreme environments, such as the human body. Even though many of us might associate the word microorganism with infections and disease, most are actually either harmless or even beneficial for us. Those commensals often fight off more dangerous bacteria and might also directly benefit their host. The human skin harbors several differen

A consensus protocol for treatment of distal radius fractures (DRF) has been developed to aid clinicians in treatment decision making. The protocol was evaluated in Paper I using a validated subjective outcome instrument, DASH in 518 consecutive patients. A good final subjective result was achieved with the proposed protocol, regardless of initial severity with a low median DASH score in all group

Plant species beta diversity is influenced by spatial heterogeneity in the environment. This heterogeneity can potentially be characterised with the help of remote sensing. We used WorldView-2 satellite data acquired over semi-natural grasslands on The Baltic island of Öland (Sweden) to examine whether dissimilarities in remote sensing response were related to fine-scale, between-plot dissimilarit

Resolving fungal and bacterial groups within the microbial decomposer community is thought to capture disparate life strategies for soil microbial decomposers, associating bacteria with an r-selected strategy for carbon (C) and nutrient use, and fungi with a K-selected strategy. Additionally, food-web model-based work has established a widely held belief that the bacterial decomposer pathway in so

Background: Systemic amyloidosis (SSA) is a common form of amyloidosis but it remains often unnoticed because of the slow progression in old patients. The cause for SSA is the accumulation of wild-type transthyretin amyloids in critical tissues. We provide here data showing that SSA may be associated with old-age non-Hodgkin lymphoma.Systemic amyloidoses include immunoglobulin light chain (AL) amy

Den Nagssugtoqidiska orogenen är ett cirka 300 km brett Paleoproterozoiskt deformerat och metamorfaserat bälte som sträcker sig över de södra och mellersta delarna av västra Grönland. Bergarterna karaktäriseras och domineras av metamorf arkeisk ortognejs och en mindre del suprakrustala sekvenser, där metasediment finns representerade. Trots sin ringa omfattning utgör de suprakrustala sekvenserna eThe Nagssugtoqidian Orogen is represented by an approximately 300 km wide Palaeoproterozoic deformation and metamorphic belt that stretch through the southern and middle parts of west Greenland. The Orogen is characterized and dominated by metamorphosed Archaean orthogneisses with minor supracrustal sequences. Despite its small extent the supracrustal sequences are an important factor in the inter

Augustenborg storm water system has become well known for its incorporation of urban green spaces. Open storm water system was developed in late 1990s by disconnecting impervious surfaces from combined sewers as a result of flooding problem in the basements after heavy rain events. The open storm water management system consists of open channels and ponds, a small wetland, green infiltration areas

“1000 Extra” is a project that takes off in the sub optimal conditions that city planning in the 20-th century has left behind for the future. First and foremost looking at the conditions of residential areas planned based on doctrines stemming in modernism, the project proposes desnsifying the not-so-dense areas in Lund, consisting of row houses and other residential buildings in the same categor