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Rates of molecular, phenotypic, and lineage diversification typically scale negatively with time interval of measurement, raising longstanding questions about time-dependency of evolutionary processes. These patterns and their potential meaning have recently re-entered evolutionary discussions. In this Perspective, we revisit the general challenges in interpreting rate–time relationships. Much app
Contemporary Nordic building design prioritizes energy-efficient HVAC systems to mitigate carbon emissions. However, this approach underestimates intensifying climate risks, creating critical vulnerabilities as extreme weather and energy/resource scarcity escalate. To address this gap, a free-running building concept, eliminating heating, cooling, and mechanical ventilation, was examined for Nordi
Magnetic resonance imaging (MRI) is the primary method for noninvasive investigations of the human brain in health, disease, and development but yields data that are difficult to interpret whenever the millimeter-scale voxels contain multiple microscopic tissue environments with different chemical and structural properties. We propose a novel MRI framework to quantify the microscopic heterogeneity
Definitive hematopoiesis emerges via an endothelial-to-hematopoietic transition in the aorta-gonad-mesonephros (AGM) region and placenta. We have recently demonstrated the induction of hematopoietic stem/progenitors (HSPCs) from mouse fibroblasts with a combination of transcription factors progressing through endothelial-like precursors. Here, guided by our in vitro programming experiments we anal
Objective: Little is known about the prevalence and impact of insomnia on clinical outcomes in youth with obsessive–compulsive disorder (OCD). This study aimed to investigate this subject. Patients/methods: A total of 193 patients from a specialist pediatric OCD clinic completed a range of diagnostic and clinical measures, including the Insomnia Severity Index (ISI). Patients scoring above a previ
This article studies the consequences of adult income resulting from exposure to poverty at the neighbourhood and family levels for children aged 1-17 in Southern Sweden from 1947 to 1967. We used geocoded information at the address level to identify k-neighbourhoods of various sizes and applied both relative and absolute poverty measurements, all yielding similar results. Moreover, our longitudin
Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from I I I men with established hypertension (diastolic pressure > 95 mmHg) from the Swedish component of an on
The ionization dynamics of Ar and Xe clusters irradiated with intense vacuum ultraviolet light from a free-electron laser is investigated using photoelectron spectroscopy. Clusters comprising between 70 and 900 atoms were irradiated with femtosecond pulses at 95 nm wavelength (similar to 13 eV photon energy) and a peak intensity of similar to 4x10(12) W/cm(2). A broad thermal distribution of emitt
The alpha 2B adrenergic receptor (A2AB) is a heptahelical G protein-coupled receptor for catecholamines. We compared the almost complete coding region (about 1,175 bp) of the A2AB gene from 48 mammalian species, including eight newly determined sequences, representing all the 18 eutherian and two marsupial orders. Comparison of the encoded proteins reveals that residues thought to be involved in a
Om filmatiseringen av Axel Wallengrens (Falstaff, fakirs) novell "Ett svårskött pastorat" (1958).
I denna artikel tar jag upp ett berättargrepp, den narrativa syllepsen, som inte fått någon större uppmärksamhet i litteraturteorin hittills. Den narrativa syllepsen definierades först av den franske litteraturteoretikern Gérard Genette år 1972 som ett berättargrepp där olika temporaliteter smälter samman. Begreppet har dock inte använts i någon större utsträckning därefter, vilket jag anser vara In this article I discuss a narrative device, the narrative syllepsis, which has not received much attention in literary theory until now. The narrative syllepsis was first defined by French literary theorist Gérard Genette as a narrative device where different temporalities merge. The concept has however not been used att a larger scale after Genette, something I find surprising taking into consi
A sensitive and selective amperometric biosensor, based on NADH-oxidase (NADOx) working in tandem with horseradish peroxidase (HRP), which is electrically connected to graphite electrode via Os-redox polymer (RP), was developed. Two designs were considered for the biosensor optimization: (i) the first one, [G/HRP-NADOx], exploited the direct electron transfer between HRP and the graphite electrode
Objective This study assessed pesticide exposure of children in rural Nicaragua in relation to parental pesticide use, from around conception to current school age, as part of an epidemiological evaluation of neurodevelopment effects. Methods We included 132 children whose parents were subsistence farmers or plantation workers, or had an agricultural history. As proxies for children's long-term ex
The in vitro replication of the Torque teno virus (IT virus) tth8 full-length genome and particle formation in a Hodgkin's lymphoma-derived cell line after transfection with cloned viral DNA were demonstrated. Analyses of the transcription patterns of tth8 and tth7 TT virus isolates in a number of lymphoma and T-cell leukemia cell lines indicated differential additional splicing events and intrage
Trade Unions are finding it increasingly challenging to appeal to employees and all trade unions alike are encountering new challenges to attract and retain members. Additionally a more diversified and educated labor market is creating demands for trade unions to better meet individual needs. The purpose of this study was to explore and analyze the role of branding in Unionen, the largest white-co
Article about the Latvian-American artist Boris Lurie, the art movement NO!art, founded by Lurie, Sam Goodman and Stanley Fischer in 1959 in New York, and the reception history of Lurie and NO!art from the 1960s until today. Accompanied by an extensive interview with Boris Lurie.
We present and analyze low-rank channel estimators for orthogonal frequency-division multiplexing (OFDM) systems using the frequency correlation of the channel. Low-rank approximations based on the discrete Fourier transform (DFT) have been proposed, but these suffer from poor performance when the channel is not sample spaced. We apply the theory of optimal rank-reduction to linear minimum mean-sq
