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The aim of the thesis is to improve the initial steps of xylose metabolism in recombinant Saccharomyces cerevisiae. S. cerevisiae takes up xylose of poor affinity by means of hexose transporters. Metabolic control analysis was used to investigate whether the low xylose utilisation rate is due to inefficient transport. Xylose transport was found to have little control over the aerobi

According to mechanobiologic theories, persistent intermittent mechanical stimulation is required to maintain differentiated cartilage. In a rat model for bone repair, we studied the fate of mechanically induced cartilage after unloading. In three groups of rats, regenerating mesenchymal tissue was submitted to different loading conditions in bone chambers. Two groups were immediately killed after

Background Calcipotriol and betamethasone dipropionate are both widely used, effective treatments for psoriasis. Vitamin D analogues and topical corticosteroids have different mechanisms of action in the treatment of psoriasis. A new vehicle has been developed in order to contain both calcipotriol (50 micro g g-1) and betamethasone dipropionate (0.5 mg g-1) in an ointment form. By using calcipotri

The objective of this work is to present a musculo-skeletal model of the lumbar spine, which can be shared and lends itself to investigation in many locations by different researchers. This has the potential for greater reproducibility and subsequent improvement of its quality from the combined effort of different research groups. The model is defined in a text-based, declarative, object-oriented

In this paper, we describe the commutant of an arbitrary subalgebra A of the algebra of functions on a set X in a crossed product of A with the integers, where the latter act on A by a composition automorphism defined via a bijection of X. The resulting conditions which are necessary and sufficient for A to be maximal abelian in the crossed product are subsequently applied to situations where thes

The value of bone mineral density (BMD) measurements to stratify fracture probability can be enhanced in a case-finding strategy that combines BMD measurement with independent clinical risk indicators. Putative risk indicators include age and gender, BMI or weight, prior fracture, the use of corticosteroids, and possibly others. The aim of the present study was to develop a mathematical framework

Sweden is a country that prides itself on its mining tradition, contributions to European self-sufficiency and, more recently, its steel transition. It focuses its greening efforts on decarbonizing and automating the steel industry. Meanwhile, destructive impacts on land and biodiversity are largely overlooked. Drawing on the literature on extractivism and on psychoanalytical conceptual literature

Det finns många faktorer som påverkar hur svårlöst en konflikt är. Vi undersöker en av dem, nämligen skuggnätverken, genom att titta på kausalsambandet mellan skuggnätverk och staters olika uppbyggnadsprocesser. Begreppet skuggnätverk är en adaption av Nordstroms ?shadows? ? det vill säga ekonomiska och politiska länkar som på både lokal och internationell nivå rör sig utanför de statliga direktiv

Problem Definition: Ericsson wants to increase their focus on reducing the total cost of packaging for the company in the whole world. They want to create a simple calculation model that can calculate the total packaging cost and compare different packaging solutions (country, freight, packaging, and product) in order to find the most cost effective packaging solution. This will facilitate the dev

Purpose: The purpose of the investigation is to give an insight to hot the EU legal environment in the field of vertical relationships influences the competitiveness of the 2nd tier of the automobile industry. Conclusion: It follows that European legislation has succeedded in raising the competitiveness by breaking down the powers of the predominantly more powerful companies that the 2nd tier play

BACKGROUND: The high prevalence of mixed phenotypes of Early Onset Ataxia (EOA) with comorbid dystonia has shifted the pathogenetic concept from the cerebellum towards the interconnected cerebellar motor network. This paper on EOA with comorbid dystonia (EOA-dystonia) explores the conceptual relationship between the motor phenotype and the cortico-basal-ganglia-ponto-cerebellar network.METHODS: In

This Element is a contribution to a new generation of corpus pragmatics research by taking as its starting point the multifaceted nature of speech acts in conversation, and by adopting a mixed-methods approach. Through a unique combination of theoretical, qualitative, quantitative, and statistical approaches, it provides a detailed investigation of advice-giving and advice uptake in relation to (i

Värmland in south western Sweden lies across the established zone of marine-terrestrial transition of the Scandinavian Ice Sheet (SIS) margin. The region lies inside the Younger Dryas maximum limit reached at 12.7 cal ka BP and the area of rapid final SIS retreat from 11.5 cal ka BP. LiDAR data across Värmland allows more detailed observation and analysis of glacial landforms formed during this st

In the present paper an iterative time-reversal algorithm, that retrofocuses an acoustic wave field to its controllable part is established. For a fixed temporal support, i.e., transducer excitation time, the algorithm generates an optimal retrofocusing in the least-squares sense. Thus the iterative time-reversal algorithm reduces the temporal support of the excitation from the requirement of neglig

PurposeThe purpose of this paper is to present an experimental study which aims at assessing the potentially misleading effect of graphic elements on food packaging. The authors call these elements potentially misleading elements (PMEs) as they can give customers false expectations. They are either highlighted numerical information (30 per cent fibre, 8 per cent fat, 100 per cent natural […]) or p