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In order to preserve the variety of life on Earth, we must understand it better. Biodiversity research is at a pivotal point with research projects generating data at an ever increasing rate. Structuring, aggregating, linking and processing these data in a meaningful way is a major challenge. The systematic application of information management and engineering technologies in the study of biodiver
Objectives To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the disease. Methods Linkage disequilibrium (LD) mapping was conducted by using 1251 SNPs (single nucleotide polymorphism) covering a 862 kb genomic region on 3p14.3 comprising the PXK locus in 1467 SLE patients and 2377 controls of Euro
We develop a representation of reverse-time migration (RTM) in terms of Fourier integral operators, the canonical relations of which are graphs. Through the dyadic parabolic decomposition of phase space, we obtain the solution of the wave equation with a boundary source and homogeneous initial conditions using wave packets. On this basis, we develop a numerical procedure for the reverse-time conti
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Standard interpolation techniques are implicitly based on the assumption that the signal lies on a single homogeneous domain. In contrast, many naturally occurring signals lie on an inhomogeneous domain, such as brain activity associated to different brain tissue. We propose an interpolation method that instead exploits prior information about domain inhomogeneity, characterized by different, pote
Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults, including a large number of adults of reproductive age. Several guidelines for the treatment of AD exist, yet specific recommendations for the treatment of pregnant or lactating women and for adults planning to have a child are often lacking. This position paper from the European Task force on Atopi
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
This chapter delves into the evaluation of national innovation policies through a case study of the Brazilian National Innovation Policy (NIP). Assessing these policies poses several challenges, including the difficulty of defining and measuring policy outcomes, the scarcity of reliable data, and the intricacies of interactions among various stakeholders involved in the policy. Additionally, polit
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine. Therefore, d-serine may well play a role in all physiological and pathological processes in which
Deficiency of subunit 6 of the conserved oligomeric Golgi (COG6) complex causes a new combined N-and O-glycosylation deficiency of the congenital disorders of glycosylation, designated as CDG-IIL (COG6-CDG). The index patient presented with a severe neurologic disease characterized by vitamin K deficiency, vomiting, intractable focal seizures, intracranial bleedings and fatal outcome in early infa
Three-phosphoglycerate dehydrogenase (3- PGDH) deficiency is a rare recessive inborn error in the biosynthesis of the amino acid L-serine characterized clinically by congenital microcephaly, psychomotor retardation, and intractable seizures. The biochemical abnormalities associated with this disorder are low concentrations of L-serine, D-serine, and glycine in cerebrospinal fluid (CSF). Only two m
A growing number of inherited disorders causing severe and progressive neurological deficits are linked to peroxisomal dysfunction. More than 15 peroxisomal diseases with neurological manifestations and some of them with dysmorphic features are identified. The diseases are classified into three groups depending on some similarities in the pathophysiology of the diseases within each group: defectiv
The goal of this research is to asses the reach and characteristics of the Phantasmatic as a proposed concept, useful to understand fundamental aspects of the romantic subjective experience in artists, aesthetes and writers. This experiential level has been exemplified in artists that had been living or intermittently residing in Dresden during the first half of 19th century. Caspar David Friedric
This interview focuses on a spectrum of urgent challenges facing marginalized human and other-than-human communities, including the intersecting crises of global anthropogenic climate disruption and state and institutional racist violence. We discuss and consider the opportunities, limits, and contradictions of pursuing transformative, intersectional political change and scholarship through effort
Droughts affect ecosystems at multiple time scales, but their sub-seasonal legacy effects on vegetation activity remain unclear. Combining the satellite-based enhanced vegetation index MODIS EVI with a novel location-specific definition of the growing season, we quantify drought impacts on sub-seasonal vegetation activity and the subsequent recovery in the Northern Hemisphere. Drought legacy effec
Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with
Background & Aims: There is substantial inter-individual variability in the risk of non-alcoholic fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR) (‘MetComp’) and part by common modifiers of genetic risk (‘GenComp’). We examined how IR on the one hand and genetic risk on the other contribute to the pathogenesis of NAFLD. Methods: We studied 846 individuals: 49
