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Background Trials of imatinib have provided evidence of activity in adults with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (ALL), but the drug's role when given with multidrug chemotherapy to children is unknown. This study assesses the safety and efficacy of oral imatinib in association with a Berlin-Frankfurt-Munster intensive chemotherapy regimen and allo geneic stem-cell tr

Plant mitochondria contain alternative external NAD(P)H dehydrogenases, which oxidise cytosolic NADH or NADPH and reduce ubiquinone without inherent linkage to proton pumping and ATP production. In potato, St-NDB1 is an external Ca2+-dependent NADPH dehydrogenase. The physiological function of this enzyme was investigated in homozygous Nicotiana sylvestris lines overexpressing St-ndb1 and co-suppr

Glucagon, secreted by the pancreatic alpha-cells, stimulates insulin secretion from neighboring beta-cells by cAMP- and protein kinase A (PKA)-dependent mechanisms, but it is not known whether glucagon also modulates its own secretion. We have addressed this issue by combining recordings of membrane capacitance (to monitor exocytosis) in individual alpha-cells with biochemical assays of glucagon s

Excessive vascular cell proliferation is an important component of pulmonary hypertension (PH). Perlecan is the major heparan sulfate (HS) proteoglycan in the vascular extracellular matrix. It binds growth factors, including FGF2, and either restricts or promotes cell proliferation. In this study, we have explored the effects of perlecan HS deficiency on pulmonary vascular development and in hypox

We use formaldehyde (HCHO) vertical column measurements from the Scanning Imaging Absorption spectrometer for Atmospheric Chartography (SCIAMACHY) and Ozone Monitoring Instrument (OMI), and a nested-grid version of the GEOS-Chem chemistry transport model, to infer an ensemble of top-down isoprene emission estimates from tropical South America during 2006, using different model configurations and a

To reach a European consensus on the definition and characterization of the main organ-specific extraglandular manifestations in primary SS.

Fertility rates have dramatically decreased in the last two decades, especially in men. It has been described that environmental factors, as well as life habits, may affect semen quality. Artificial intelligence techniques are now an emerging methodology as decision support systems in medicine. In this paper we compare three artificial intelligence techniques, decision trees, Multilayer Perceptron

Introduction. Over the years, Outcome Measures in Rheumatology Clinical Trials (OMERACT) has worked toward consensus on core sets for outcome measurement in specific rheumatologic diseases. OMERACT core sets refer to the minimum number of domains and instruments essential to address the desired outcomes in trials. "Domains" are the attributes of an activity or function. This article discusses the

Objective: To better understand the seemingly contradictory plasma beta-amyloid (A beta) results in Alzheimer's disease (AD) patients by using a newly developed plasma A beta assay, the INNO-BIA plasma A beta forms, in a multicenter study. Methods: A combined retrospective analysis of plasma A beta isoforms on mild cognitive impairment (MCI) from three large cross-sectional studies involving 643 s

The development of improved biomass pyrolysis models is vital for more accurate modelling and design of biomass conversion equipment. Such improved models must be based on reliable experimental data: biomass should be pyrolyzed at high heating rates and the reaction products should be measured using an on-line, non-intrusive method. Therefore, a heated grid reactor with heating rate of 300-600 K/s

A departing assumption in my work is the idea about a particular kind of conflict inherent in the theatrical line, produced by its situatedness in the specific relational doubt created in the speaking, performing voice and body, a space articulated already in the written line, as writing intended to be spoken. To the inherent self-contradiction in such utterances are added the layers of conscious

We report the near-field imaging characterization of a 10 Hz Ni-like 18.9 nm molybdenum soft-x-ray laser pumped in a grazing incidence pumping (GRIP) geometry with a table-top laser driver. We investigate the effect of varying the GRIP angle on the spatial behavior of the soft-x-ray laser source. After multiparameter optimization, we were able to find conditions to generate routinely a high-repeti

Excited levels in As-69 were studied using the Ca-40(S-32,3p)As-69 reaction at 95 and 105 MeV beam energy. Gamma rays were detected with the EUROBALL spectrometer operated in conjunction with the Neutron Wall and the charged-particle detector array EUCLIDES. New level sequences with positive and negative parity were identified from 3p-gammagamma and gammagammagamma coincidences. Spins were assigne

A soft x- ray laser from Ni- like Mo, pumped in grazing incidence ( GRIP), is analyzed with regard to high repetition rate operation. Reliable lasing is obtained, but with significant energy fluctuations attributed mainly to beam pointing jitter from the pump laser. Two modes of operation are compared: continuously moving target and stationary target. With a moving target the soft X- ray output is

Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyte nuclear factor 4alpha (HNF4alpha) (the MODY1 gene) with risk for type 2 diabetes. We attempted to reproduce this putative association by genotyping 11 single nucleotide polymorphism (SNPs) spanning the HNF4a coding region and the P2 promoter in >3,400 patients and control subjects from Sweden, Fin

Background/Aim: Matrix metalloproteinases (MMPs) are involved in cancer biology. Expression of MMP7 (matrilysin) in colorectal cancer is associated with metastatic disease even though it is expressed in most tumour states. In the present study, our purpose was to analyze MMP7 in bowel and lymph nodes of different tumour stages and to evaluate its expression as a cancer biomarker. Patients and Meth

The objective of this study has been to create an online system for condition monitoring and diagnosis for a combined heat- and power plant in Sweden. This system consists of artificial neural network models, representing each main component of the combined heat- and power plant, accompanied with a graphical user interface. The artificial neural network models are integrated on a power generation

Energy efficiency has gained attention as an important means of ensuring energy supply, fostering countries’ competitiveness and cost-effectively mitigating CO2 emissions. Yet, evaluations of energy efficiency policies are often lacking or insufficient. Moreover, researchers have tended to overlook these types of policies in non-OECD countries, although at this very moment many of these countries