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The biosynthesis of flavonoids and proanthocyanidins was studied in cultivated strawberry (Fragaria x ananassa) by combining biochemical and molecular approaches. Chemical analyses showed that ripe strawberries accumulate high amounts of pelargonidin-derived anthocyanins, and a larger pool of 3',4'-hydroxylated proanthocyanidins. Activities and properties of major recombinant enzymes were demonstr

Background The methyl ester form of fumaric acid named dimethyl fumarate (DMF) is an effective mould-growth inhibitor. Its irritating and sensitizing properties were demonstrated in animal models. Recently, DMF has been identified as responsible for furniture contact dermatitis in Europe. Objective To describe the clinical manifestations, patch test results, shoe chemical analysis, and source of e

Many nitrosamines are suspected of being human carcinogens, with the highest concentrations in the environment being measured in the rubber industry. Time trends of personal exposure to N-nitrosodimethylamine (NDMA) and to N-nitrosomorpholine (NMor) during the past two decades in the German rubber industry were analysed and compared with cross-sectional studies in the same period in the Netherland

Aims/hypothesis: The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). This was t

Background: Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is

We present a reflector antenna system using a circular polarization selective surface (CPSS) to realize a circular polarization (CP) equivalent to the widely used linear polarization (LP) gridded or dual-gridded reflector (DGR). The CPSS is realized by a multilayer stack of non-resonant anisotropic meander line surfaces, achieving a very wide bandwidth. The CPSS reflection and transmission dyadics

With the goal to delevop the fabrication of a new type of Pt-nanoparticle carbon-support electrocatalyst, we investigate the carbon embedding of Pt cluster superlattices grown on the moiré of a monolayer of hexagonal boron nitride (h-BN) on Ir(111). Our combined scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS) study establishes conformal C embedding of the Pt clusters

Objective To evaluate current evidence on the efficacy and safety of topical and systemic medications in patients with primary Sjögren syndrome (SjS) to inform European League Against Rheumatism treatment recommendations. Methods The MEDLINE, EMBASE and Cochrane databases were searched for case-control/prospective cohort studies, randomised controlled trials (RCTs) and systematic reviews. Results

Water has long been a strategic resource in the semi-arid landscapes of Mesopotamia, a region spanning Turkey, Syria, and Iraq, where the Tigris and Euphrates rivers form the lifeline of societies. As water scarcity intensifies due to a combination of climatic stressors and anthropogenic pressures, the governance of transboundary rivers has become critical for ensuring health, food security, and r

Uppsatsen har två huvudsakliga syften. Dels att utreda rättsläget rörande anställdas yttrandefrihet och kritikrätt på svensk och europeisk nivå, dels att undersöka vilket skydd svensk rätt ger anställda som avslöjar missförhållanden på arbetsplatsen, s.k. whistleblowing. Bedömningen av det senare sker mot bakgrund av den särskilda whistleblowinglagstiftningen i Norge och England. I svensk rätt äThe thesis has two main purposes. The first one aims at establishing the current legal situation for employees’ freedom of expression and right to criticize the organization in which they work. This is done on a national level as well as on a European level. The second purpose is to investigate the level of protection that Swedish law provides for so called whistleblowers; employees who reveal pos

Non-harmonized direct taxes fall within the Member States' competence. This means that the Member States are free to develop their own tax systems, as long as there is no Community harmonisation. But since the freedom of establishment (and other rights under the EC Treaty) could be disturbed by national tax law, this competence must be exercised in consistency with Community law to avoid any d

The condemnation of the specialized procedures of the faulty military commission system, particularly ex parte and in camera hearings to determine the closure of confidential information, has resulted in the contention that terror cases may be properly adjudicated in regularly constituted Article III courts. Proponents of prosecution of terror suspects in federal civilian courts assert that the co

Somatostatin, produced by pancreatic islet δ cells, is a key intra-islet paracrine factor that regulates the secretion of the glucoregulatory hormones insulin and glucagon from β cells and α cells, respectively. Here, we show that glutamate and glucagon released by α cells cooperatively activate neighbouring δ cells through AMPA and glucagon receptors, thereby enabling spatiotemporal feedback cont

INTRODUCTIONBoreal forests are crucial for mitigating global climate change by capturing and storing large amounts of atmospheric carbon dioxide. However, previously unmanaged primary boreal forests are being rapidly transformed to managed secondary forests to meet the rising global demand for materials and energy. Understanding the effects of boreal primary to managed secondary forest transformat

BACKGROUND: The incidence of postoperative pulmonary complications (PPCs3) following abdominal surgery varies across surgical specialties. It remains unclear to what extent the incidence of PPCs is attributable to known patient-related factors and anaesthesia duration, rather than to differences inherent to the surgical specialty itself.METHODS: Post-hoc analysis of an observational study describi

We consider two optimization problems in which a planner aims to influence the average transient opinion in the Friedkin-Johnsen dynamics on a network by intervening on the agents' innate opinions. Solving these problems requires full network knowledge, which is often not available because of the cost involved in collecting this information or due to privacy considerations. For this reason, we foc

Cold acclimation is a crucial physiological process that enables plants to adapt to low temperatures. A key aspect of this acclimation is lipid remodeling, which preserves membrane fluidity and integrity under cold stress. Proteins of the chloroplast envelope membranes are increasingly recognized for their role in acclimation to changing environmental conditions. While lipid synthesis occurs at th

Our relationships with others structure many aspects of our lives, especially during important moments such as choosing an education, entering the workforce, forming partnerships or starting a family. While the influence of family and parenting has been widely studied, less is known about the role of non-family connections, such as neighbours. One reason is that the data needed to study these rela