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Background - In patients with chronic heart failure (CHF), a beta-blocker is generally added to a regimen containing an angiotensin-converting-enzyme ( ACE) inhibitor. It is unknown whether beta-blockade as initial therapy may be as useful. Methods and Results - We randomized 1010 patients with mild to moderate CHF and left ventricular ejection fraction <= 35%, who were not receiving ACE inhibitor
Popular Abstract in Swedish Gangesfloden i Varanasi (Indien) anses samtidigt vara fullkomligt ren och svårt förorenad, beroende på vem som definierar dess egenskaper, brahminska religiösa specialister eller vetenskapligt orienterade miljöaktivister. Medan kontroversen fortgår, försöker några hinduiska religiösa ledare att anpassa sina traditioner till de nya miljöparadigmen, och deras förhållningsWhether the Ganges river in Varanasi (India) is pristinely pure or heavily polluted depends on by whom it qualities are defined, the Brahmin religious specialists in the city or the science oriented environmentalists. While the controversy continues, some Hindu religious leaders are searching for ways to adjust their respective traditions to the environmental paradigms, an initiative that reflects
Wheat flour and cane sugar were partially substituted (50 and 75%) by a mango-processing by-product (MPB) as an added-value food ingredient in muffins. Their sensory analysis, chemical composition, antioxidant activity and in vitro starch hydrolysis properties were studied. Sensory analysis showed statistically significant difference (p < 0.05) between control and muffins 75% MPB substituted level
Chemical weathering of silicate minerals releases elements into solution whereas the neoformation of secondary minerals works in the opposite direction, potentially confounding estimates of silicate weathering rates. Silicon isotopes (d30Si) may be a useful tool to investigate these processes. Here, we present 82 d30Si measurements from surface waters, pore waters, biogenic silica (BSi), clays, sa
We consider the problem of approximating a given function in two dimensions by a sum of exponential functions, with complex-valued exponents and coefficients. In contrast to Fourier representations where the exponentials are fixed, we consider the nonlinear problem of choosing both the exponents and coefficients. In this way we obtain accurate approximations with only few terms. Our approach is bu
The aim of this paper is to present the software development techniques used to build the EIS Patterns development framework, which is a testbed for a series of techniques that aim at giving more flexibility to EIS in general. Some of these techniques are customizations or extensions of practices created by the agile software development movement, while others represent new proposals. This paper a
Lignocellulose constitutes a vast renewable resource for the production of, for example, paper and bioethanol. The potential of using laccase and oxalate-degrading enzymes in novel applications for the processing of lignocellulose was investigated in this work. Laccase cDNAs from the white-rot fungus Trametes versicolor were characterised and expressed in Saccharomyces cerevisiae and Pichia pastor
The challenges for creating a greener economy and the institutional framework for sustainable development pass necessarily, or mostly, through cities, as they concentrate a large and growing part of the world’s economy and population, as well as decision-making power. With the processes of urbanization and rural-urban transformation, the economy in cities, especially in cities of developing countr
Molecular imprinting technology is derived from the concept of creating designed recognition sites in macromolecular matrices by means of template polymerisation. Molecularly imprinted polymers are able to mimic recognition in natural binding events, such as antibody-antigen and receptor-ligand interactions. This thesis addresses some aspects of the preparation of molecularly imprinted polymers an
A cultivation strategy combining the advantages of temperature limitedfed-batch and probing control is presented.This is a suitable way to produce recombinant proteins while minimizing therelease of endotoxins which complicates the downstream processing.The downside with the temperature limited fed-batch technique has been the difficulty to achieve a controlled excess of glucose inthe reactor with
The study examines a hitherto neglected genre in Swedish poetry of the 17th and 18th centuries: the animal epitaph. From 1670 to 1760 a considerable number of such poems were composed by several of the leading poets of the day. Besides tracing the history of the genre back to its origins in the ancient Greek epigram, I am chiefly concerned with the functions that the writing of such epigrams had i
The importance of prioritising requirements is widely recognised. A number of different techniques for prioritising requirements have been proposed, some based on an ordinal scale, others on a ratio scale. Some measurement scales provide more information than others, i.e. the ratio scale is richer than the ordinal scale. This paper aims to investigate the differences between the scales used in pri
Ion beam methods are used to analyse material (Ion Beam Analysis, IBA) and to modify the target (Ion Beam Modification of Materials, IBMM). In this thesis, ion beams have been used in various IBA techniques to investigate the surface nanometre structures, and also in an ion beam synthesis (IBS) technique to form thin films and to modify material properties. The work is divided into two main parts:
Popular Abstract in Swedish Syftet med den här avhandlingen har varit att studera association och växelverkan mellan proteiner och polymerer. Två olika tekniker har använts i dessa studier; datorsimuleringar och fördelning i polymera vattenhaltiga tvåfassystem. Vikten av att studera protein-polymer-växelverkan ligger i att flera biotekniska, och medicinska tillämpningar baserar sig just på proteiThe aim of this thesis has been to study protein-polymer interaction and association. Two different techniques were used; Monte Carlo simulations were combined with partitioning in polymeric aqueous two-phase systems. Monte Carlo simulations have been used to evaluate the hydrophobic interaction in electrolyte solution. The results showed that monovalent salt only slightly increases the hydrophob
Natural products have traditionally played a major role in the drug discovery process. Besides constituting extremely popular drugs in the market, and an ever-increasing source of interesting and novel chemical structures, they have also aided the characterization of many a pharmacological target. And although natural product-oriented research has suffered from a declining interest from the pharma
A low intake of calcium is widely considered to be a risk factor for future fracture. The aim of this study was to quantify this risk on an international basis and to explore the effect of age, gender and bone mineral density (BMD) on this risk. We studied 39,563 men and women (69% female) from six prospectively studied cohorts comprising EVOS/EPOS, CaMos, DOES, the Rotterdam study, the Sheffield
