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Science Journals — AAAS Xhonneux et al., Sci. Transl. Med. 13, eabd5666 (2021) 31 March 2021 S C I E N C E T R A N S L A T I O N A L M E D I C I N E | R E S E A R C H R E S O U R C E 1 of 15 M E T A B O L I S M Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression Louis-Pascal Xhonneux1,2, Oliver Knight1,2, Åke Lernmark3, Ezio Bonifacio4, William A. Hag

https://www.teddy.lu.se/sites/teddy.lu.se/files/2022-01/130%2009242021_679_130_MP233_Xhonneux_SciTranslMed_2021.pdf - 2026-07-23

This dissertation is a collection of seven papers in which a number of questions are investigated regarding verbs that take a sentential complement as their direct object. These verbs are considered from different perspectives, namely from the perspective of the propositional attitude they express, or from the perspective of the syntactic construction they select, or from the point of view of the

Allergen-induced late airway response offers important pharmacodynamic targets, including T helper 2 (TH2) biomarkers. However, detection of inflammatory markers has been limited in dithiothreitol-processed sputum.

Acute coronary syndrome (ACS), including acute myocardial infarction (AMI), are a leading cause ofmorbidity and mortality worldwide. Accurate risk evaluation in patients presenting with chest pain isessential for optimizing emergency department (ED) resource allocation and patient outcomes. Currentclinical decision support tools rely on structured risk scores and biomarker measurements, such as hi

Background: Guidance on managing acute mesenteric ischaemia (AMI) is largely based on expert opinion and retrospective studies pooling different subtypes of AMI. In clinical practice, management strategy is often selected based on the patient’s severity of illness, whereas randomized controlled trials or even adjusted analyses comparing different strategies are rarely available. We aimed to perfor

Selective inheritance of sub-cellular components has emerged as a mechanism guiding stem cell fate after asymmetric cell divisions. Peroxisomes play a crucial role in multiple metabolic processes such as fatty acid metabolism and reactive oxygen species detoxification, but the apportioning of peroxisomes during stem cell division remains understudied. Here, we develop a mouse model and labeling te

Objective In patients with Crohn’s disease (CD) on combination therapy (infliximab and immunosuppressant) and stopping infliximab (cohort from the study of infliximab diSconTinuation in CrOhn’s disease patients in stable Remission on combined therapy with Immunosuppressors (STORI)), the risk of short-term (≤6 months) and mid/long-term relapse (>6 months) was associated with distinct blood protein

Ground-level ozone (O3), formed via complex photochemistry involving nitrogen oxides (NOx) and volatile organic compounds (VOCs), is a critical secondary pollutant and oxidant. Therefore, understanding whether the formation of O3 is NOx- or VOC-limited is essential for effective air quality management. Recently, we demonstrated that the distribution of highly oxygenated organic molecules (HOMs) ca

Semi-arid ecosystems, common across the Australian continent, strongly influence the inter-annual variability and trend in the global terrestrial net carbon sink. Here we explore the future Australian terrestrial carbon cycle using the CMIP6 ensemble, and the dynamic global vegetation model LPJ-GUESS. Uncertainty in Australia's carbon storage in vegetation ranged between 6 and 49 PgC at the end of

Introduction and objectives: This study aimed to describe the cardiovascular risk profile of working young adults from Spain and its association with lifestyle. Methods: Participants (18-30 years) were recruited from a nationwide cohort of economically active adults insured by a large occupational risk prevention company, with data obtained from routine medical assessments. The participants were c

Cities typically treat migration and sustainability as separate policy domains. When migration is highlighted in the context of sustainability in urban destination areas, it is typically understood to have no, or at worst, negative impacts on sustainability. As a result, migration and migrants are commonly left out of sustainability policy and planning. Here, we present emerging evidence to refram

Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism (VTE). The goal of this pooled analysis of 8 case-control studies, comprising a total of 2310 cases and 3204 controls, was to precisely estimate the risk of VTE in patients bearing both mutations (double heterozygotes). Odds ratios for VTE were 4.9 (95% CI; 4.1-5.9) for the fact

Purpose: to propose two enhancements for the European Union’s Circular Material Use rate (CMU): inclusion of Preparation for Reuse (PfR) flows and enhanced reproducibility across lower levels of analysis. Methods: PfR flows are added to the material flow Sankey Diagram. The Local Circularity Rate (LCR) is based in the CMU and is broke down in three waste-related ratios: recovered-to-treated (RCV-t

Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar