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Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wal
Background: Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis. Methods: We did data-driven cluster analysis (k-means and hierarchical clusterin
In this paper we construct a hierarchical model for spatial compositional data which is used to reconstruct past land-cover compositions (in terms of coniferous forest, broadleaved forest, and unforested/open land) for five time periods during the past 6000 years over Europe. The model consists of a Gaussian Markov Random Field (GMRF) with Dirichlet observations. A block updated Markov chain Monte
Popular Abstract in English Research has shown the Ugandan construction industry to be, primarily, an informal sector dominated by unskilled labour contracted mainly on minor building works such as alterations and renovations. Within such a context, the industry has also received negative publicity due to increasing quality failures on sites – commonly referred to as shoddy work. Some reasons citeResearch has shown the Ugandan construction industry to be, primarily, an informal sector dominated by unskilled labour contracted mainly on minor building works such as alterations and renovations. Within such a context, the industry has also received negative publicity due to increasing quality failures on sites – commonly referred to as shoddy work. Some reasons cited for these failures include
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and ao
Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of t
Objectives: Detecting particle flow from the airways by a non-invasive analyzing technique might serve as an additional tool to monitor mechanical ventilation. In the present study, we used a customized particles in exhaled air (PExA) technique, which is an optical particle counter for the monitoring of particle flow in exhaled air. We studied particle flow while increasing and releasing positive
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 3
LPJ-GUESS is an advanced DGVM including detailed forest demography and management, croplands, wetlands, specialised arctic processes, emissions of nonCO2 GHGs and a highly flexible land-use change scheme which tracks transitions between different land-uses. It is the vegetation component of the EC-Earth CMIP6 ESM, the RCA-GUESS regional ESM, and also has a European mode operating at tree species l
AIMS: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking.METHODS AND RESULTS: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness
Sensory traits shape animal lifestyles due to the central role they play in retrieving and processing environmental information. However, being some of the most energetically expensive tissues to build and maintain, ecological demands often modulate investment in these organs. Evidence that ecology shapes the evolution of sensory traits is plenty but is heavily biased towards vertebrates and has o
Carbon sequestration in arable soils is gaining increasing attention in global policymaking initiatives for climate-change mitigation. Large-scale assessments of soil organic carbon development in arable land are affected by the scarcity of reliable time series of soil organic carbon monitoring data and often fail to replicate observed trends or appreciate any effects induced by changes in soil ma
Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r
OBJECTIVES: To reach agreement among experts on visual assessments of postural orientation errors (POEs) during the single-leg squat (SLS), and to use expert agreement assessments as ground truth for machine learning (ML) models to evaluate their ability to classify POEs.DESIGN: Methodological study with mixed-methods design.METHODS: POEs of the lower extremity and trunk were assessed from videos
IntroductionThe ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. This suggests underlying protective mechanisms. Initiated in September 2022, this exploratory study aims to uncover and define these mechanisms, potentially leading to nove
Bygg- och fastighetssektorn står för en betydande del av Sveriges och EU:s energianvändning och klimatpåverkan. Samtidigt ökar behovet av energieffektiva bostäder i takt med befolkningstillväxt och ökade krav på klimatanpassning och hållbarhet. Energieffektivisering inom byggnadssektorn lyfts därför fram som en central åtgärd för att minska energianvändning och växthusgasutsläpp. Utöver tekniska lBygg- och fastighetssektorn står för en betydande del av Sveriges och EU:s energianvändning och klimatpåverkan. Samtidigt ökar behovet av energieffektiva bostädeThis thesis investigates how window airing behavior affects indoor environment and energy use in residential buildings. The study focuses on the relationship between airing, indoor temperature, CO₂ concentration, and how different represen
