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Popular Abstract in Swedish Cancer behandlas i första hand med kirurgi, cellgifter och extern strålbehandling. Under senare år har man dessutom utvecklat så kallade målsökande behandlingar, som binder till en viss struktur i tumören. De kan verka på olika sätt: antingen genom att blockera en signal i cellerna och på så vis hindra tumören från att växa, eller genom att stimulera patientens immunförIn radioimmunotherapy, monoclonal antibodies (mAbs) are used as a targeting agent carrying a toxic payload consisting of radionuclides. This treatment allows the irradiation of small lesions, even on the microscopic level. In the present work, two radionuclides with different properties were used. Lutetium-177 (177Lu) is a beta-particle-emitting radionuclide (t½=6.7 days) and astatine-211 (211At)

This thesis presents the results of an investigation into BIM implementation prerequisites emerging as a set of procedural supporting mechanisms that may enable design, construction and operating (DCO) organisations to advance their deployment of Building Information Modelling (BIM) technology, and improve construction project outcomes. Today, BIM is centre-stage within the construction sector the

This thesis investigates the topic of joint positioning and radio channel estimation and prediction. Both positioning and radio channel estimation have a long history of research with many publications but the combination of the two has so far at large been left unexplored. The reason for studying this topic is twofold: improvement of positioning and improvement of radio channel prediction. Positi

On 25 March 2015, the Enlarged Board of Appeal of the European Patent Office (EBA) finally delivered its’ much awaited decisions on the consolidated referrals G2/12 (“Tomato II”) and G2/13 (“Broccoli II”). The EBA affirmed that products, namely plants or parts thereof, obtained by essentially biological processes are – unlike individual plant varieties – principally patentable under the European P

At the same time as our dependence on IT systems increases, the number of reports of problems caused by failures of critical IT systems has also increased. Today, almost every societal system or service, e.g., water supply, power supply, transportation, depends on IT systems, and failures of these systems have serious and negative effects on society. In general, public organizations are responsibl

The mechanisms which lead to secondary brain damage following transient ischaemia are incompletely defined. As discussed in this hypothesis article, the events which lead to such damage could encompass (a) a perturbed membrane handling of calcium, leading to a slow, gradual increase in the free cytosolic calcium concentration (Ca2(i)), with subsequent calcium overload of mitochondria, (b) a sustai

Energy metabolism dyshomeostasis is associated with multiple health problems. For example, abundant epidemiological data show that obesity and overweight increase the risk of cardiometabolic diseases and early mortality. Type 2 diabetes (T2D), characterized by chronically elevated blood glucose, is also associated with debilitating complications, high healthcare costs and mortality, with cardiovas

Late effects of polio (LEoP), a chronic progressive neuromuscular condition that affects people who have had polio earlier in life. LEoP manifests with new symptoms such as muscle weakness, fatigue, and pain, and can also have consequences for an individual’s level of activity and participation. People with LEoP can benefit from comprehensive rehabilitation, with focus on enabling activity and par

AIMS/HYPOTHESIS: Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity

Sustainability has been on the agenda of international organisations, states and, increasingly, private businesses for some time. From a competition agency perspective, regulation to achieve sustainability might be the preferred option. Yet, business action might equally affect sustainability and competition and competition laws are crucial considerations for businesses. Occasionally, the debate i

Importance: Preterm birth has been associated with increased risk of heart failure (HF) early in life, but its association with new-onset HF in adulthood appears to be unknown. Objective: To determine whether preterm birth is associated with increased risk of HF from childhood into mid-adulthood in a large population-based cohort. Design, Setting, and Participants: This national cohort study was c

Popular Abstract in Swedish Vatten är inte bara en oumbärlig resurs varav allt liv är beroende. Det är också en grundläggande ekonomisk resurs för samhällsutvecklingen. Av allt vatten på jorden är bara 0,34% tillgängligt för människan. Övriga vattenresurser föreligger som saltvatten, is eller djupt liggande grundvatten. Vattenkrisen på jorden är stor och över 780 miljoner människor saknar rimlig tFresh water scarcity, pollution and an uneven distribution have caused an increasingly serious global water crisis. One of the most widely adopted response strategies is the exploitation and use of non-conventional water sources. Water reuse and desalination were in focus in the study which was aimed to develop the strategies to promote the sustainable and safe use of reclaimed water and desalinat

According to Sahlberg (2011) educational reforms in different countries follow similar patterns as well as educational systems. Sahlberg calls this Global Educational Reform Movement (GERM) and its symptoms are: More competition within education systems, which leads to accountability (inspections, standardized tests, assessing teacher effectiveness) and less cooperation, increased school choice (c

In order to increase the competitiveness of timber as a building material in outdoor applications, durability and dimensional stability must be ensured. Acetylation enables an environmentally friendly way to increase both durability and dimensional stability of wood, without introducing harmful substances to the environment. The focus of the present research is to examine the possibility of adding

Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcin

This study concerns materials logistics in the construction processes of complex building projects in urban developing areas, where the authors have carried out a case study on the future urban renewal project Oceanpiren, H+. Urban renewable projects can be regarded as a common category in construction, due to increasing urbanization followed by an enhanced demand. This type of project is often re

Slam från konventionell avloppsvattenrening innehåller näringsämnen samt mullbildande ämnen vilket medför att materialet utgör en resurs som växtnäring och jordförbättringsmedel. Problematiken med att använda slam är att det även innehåller främmande ämnen som metaller och svårnedbrytbara organiska föreningar. Syvab är ett kommunalt bolag som driver Himmerfjärdsverket men ansvarar också för någrSludge is produced in conventional waste water treatment. The sludge contains nutrients and humic formaing substances which make it useful as a fertilizer. The problem with using sludge is that it also contains toxicants as heavy metals and persistent organic compounds. Syvab is a municipal owned corporation that manage the wastewater treatment plant Him-merfjärdsverket. Since August 2010 Himmer

Miyake et al. (2012,2013) upptäckte en snabb ökning av 14C i träringar daterade till 774-5 och 992-3 vilket tillskrevs exceptionalla kosmik strålnings händelser. Dessa extrema partikel händelser har inget motstycke i instrumentala eller hstoriska arkiv och blev följdaktigen mycket uppmärksammade. Många studier har försöt koppla samman dessa två händelser med sol protonstormar (SPE), supernovor, gaMiyake et al. (2012, 2013) discovered rapid increases of 14C content in tree rings dated to AD 774-5 and AD 992-3 which were attributed to unprecedented cosmic-ray events. These extreme particle events have no counterparts in the instrumental and historical record and consequently praised great interest. Indeed, many studies have tentatively associated the two events to solar proton events (SPE),

Aktiebolag är i behov av kapital. Detta beror dels på ett lagstadgat krav om att alla aktiebolag måste inneha ett aktiekapital, dels på att olika affärsprojekt och investeringar kostar pengar. Det finns nackdelar med samtliga befintliga finansieringsalternativ. Av denna anledning utreds i detta arbete, med användande av den rättsdogmatiska metoden, om en alternativ lösning för kapitalanskaffning iLimited companies are in need of capital. This is partly due to the statutory requirement that all limited companies must hold a share capital, but also because of the fact that different business projects and investments cost money. The existing financing options all have some disadvantages. As a result, this essay investigates an alternative solution for the raising of capital in limited compani

Intradialytic hypotension (IDH) is a major drawback of haemodialysis and occurs in more than every fifth dialysis treatment. There is a need for real-time measurement, with an ability to detect IDH before it occurs. Photoplethysmography (PPG) may provide sufficient information about hemodynamic status to prevent IDH. In particular, the venous component may be useful. This thesis aims to investiga