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Mantle cell lymphoma (MCL) is considered incurable. Intensive immunochemotherapy with stem cell support has not been tested in large, prospective series. In the 2nd Nordic MCL trial, we treated 160 consecutive, untreated patients younger than 66 years in a phase 2 protocol with dose-intensified induction immunochemotherapy with rituximab (R) + cyclophosphamide, vincristine, doxorubicin, prednisone
Purpose The purpose is to identify, categorise and describe barriers for a fossil-free transport system for urban goods. Design/methodology/approach The barriers are studied from a systems perspective in a case of a mid-sized Nordic city. Data are collected from 15 semi-structured interviews with officials from the city and representatives of private companies, and from policy documents and a work
The concept of measuring the proportions of various forms of PSA in serum, particularly the proportion of free to total PSA, represents a new and exciting method of detecting early curable prostate cancers and avoiding unnecessary prostate biopsies in men who have BPH only. Compared with other methods of improving diagnostic specificity, it does not require transrectal ultrasound for determination
We evaluated clinical significance of serum alpha-fetoprotein (AFP)-IgM immune complexes, in comparison with free AFP, on the diagnosis of primary hepatocellular carcinoma (HCC). Serum levels of AFP-IgM immune complexes and free AFP were determined by the ELISA method and electrochemiluminescence, respectively, in 103 healthy controls, 74 patients suffering from primary HCC, 27 patients suffering
Open Access journals are journals whose content is freely available to readers; publication costs are covered through a financial model other than subscription. More and more research fields are gaining good, open access alternatives for publishing as the number of OA journals increases. Find OA journalsThe Directory of Open Access Journals (DOAJ) is the largest database of quality controlled OA j
https://www.lub.lu.se/en/services-and-support/publishing-and-registering/open-access/oa-journals - 2026-06-23
This study analyzed daily temperature data from 114 meteorological stations in the Qinling-Daba Mountains from 1980 to 2017, focusing on core zones (CE I ≥ 2274 m, CE II 1321–2274 m) and peripheral zones (PE I 668–1321 m, PE II < 668 m). Using 15 extreme temperature indices computed with RClimDex, we assessed the spatiotemporal patterns, trends, and response to climate warming of extreme temperatu
The mechanism of ascorbate oxidation was studied in rat liver microsomes. A continuous consumption of the added ascorbate was observed, which was accompanied with a prompt appearance of ascorbyl free radical and dehydroascorbate. Microsomes sustained steady-state level of ascorbyl free radical and dehydroascorbate till ascorbate was present in the medium. Ascorbyl free radical formation was dimini
Metal halide perovskite nanowires are widely studied due to their unique electronic and optical characteristics, making them promising for light emitting and detection applications. We developed a ligand-free method to grow vertically aligned free-standing CsPbBr3 nanowires from anodized aluminum oxide nanopore substrates. Here, we investigate the growth process using in situ microscopy with ultra
Godstransporter är livsviktiga för att en stad och stadslivet ska fungera, men sättet som godstransporter genomförs idag är inte hållbart. Det finns få riktlinjer på hur transporterna ska ske och riskfyllda situationer uppstod. Syftet med examensarbetet var att undersöka problem i bilfria områden i centrumnära stadsmiljö, samt att komma med rekommendationer på hur det kan utvecklas utifrån dagens Urban freight transportation is crucial for the functioning of a city and city life. However, the way urban freight transportation is occurring is unsustainable since there are few regulations and dangerous situations easily arise. The purpose of the thesis was to examine transportation in car-free areas and identify the associated problems, guidelines and explore potential solutions to the identi
Hushållens skuldsättningsgrad i Sverige är hög både internationellt och historiskt sett och förväntas fortsätta växa under många år framöver. Hushållens höga skuldsättning gynnar den ekonomiska tillväxten i landet. Samtidigt kan det innebära en risk för den finansiella stabiliteten och för den svenska ekonomin i stort. Hög skuldsättning och stigande bostadspriser har förvärrat konjunkturnedgångar The Swedish household debts are, both internationally and historically, high and are expected to increase for many years to come. High household debt is beneficial for the economic growth in the country, but may at the same time implicate a risk to the financial stability and for the Swedish economy in general. High household debts and rising housing prices have made economic turndowns worse in se
Microsoft Word - Document2 HuMeNS* Advanced Study Group on neuroscience of knowledge acquisition *Humanities, Medicine, Natural Science, Social Science Background and Goal The HuMeNS Advanced Study Group has been formed as a result of the members' mutual interest in carrying out interdisciplinary studies on the microstructure of human cognition, in particular studies on changes in the brain's cell
https://www.pi.lu.se/sites/pi.lu.se/files/humens_2013-14_description.pdf - 2026-06-25
Open access publishing means that research results are published freely available online. Research funders are increasingly demanding open access publishing. Lund University has a policy on publishing, where researchers are encouraged to publish open access as much as possible in order to increase research visibility, use and impact. Page navigationSupport for publication fees and publisher agreem
The effects of nine different anionic and cationic micelle-forming surfactants on the viscosity and viscoelasticity of semidilute solutions of hydrophobically modified hydroxyethyl cellulose (HMHEC) were studied. All added surfactants gave rise to the well-established viscosity maximum with increasing surfactant concentration, but the total surfactant concentration at the maximum, as well as the m
Several important technical properties of spray-dried food powders depend on particle-liquid interactions (e.g. wettability, dispersability) and particle-particle interactions (e.g. flowability). It can be assumed that the chemical composition of the surface layer of the particles to a large extent determine these properties. The present study has been aimed to investigate the relation between the
Introduction: Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this ge
The effects of polyamines were investigated in strips of smooth muscle from guinea pig ileum permeabilized with beta-escin (0.005%). Spermine (1 mM) inhibited transient contractions induced in Ca(2+)-free medium by carbachol (0.1 mM) and GTP gamma S (0.1 mM) but potentiated responses to caffeine (20 mM) and D-myo-inositol 1,4,5-trisphosphate (40 microM). At high ethylene glycol-bis(beta-amino-ethy
Objective: We reviewed the literature on nodal staging in patients with bladder cancer treated with radical cystectomy and lymphadenectomy. Results: Fractionating the lymph node specimen significantly increases the node count, whereas results are contradictory as to whether that increase improves detection of positive nodes. Pathoanatomic data indicate that extending lymph node dissection to the a
Mixtures of an amphiphilic graft copolymer in water/sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/cyclohexane oil-continuous microemulsions are studied by the PGSE NMR technique and by viscometry. The graft copolymer has an oil-soluble poly(dodecyl methacrylate) backbone and water-soluble poly(ethylene glycol) side chains. Water, surfactant, and polymer self-diffusion coefficients can be measured
This paper examines the trade and specialization effects of China’s regional integration with South East Asia. Production fragmentation enables a firm or country to specialize in upstream, midstream or downstream activities rather than the whole production chain. A decrease in tariffs and other service link costs justify outsourcing or re-locating production to the country with best location a
The polycations spermine, neomycin and polylysine potentiated Ca(2+)-activated force in beta-escin permeabilized guinea-pig ileum strips. The effect was inhibited by the calmodulin antagonists trifluoperazine, mastoparan and W13. Potentiation was slow or absent in chi-toxin permeabilized strips, indicating dependence on penetration of the polycations into cells. The effects of spermine and neomyci
