Filtyp
Objective To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). Methods We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated in regression models, for time-dependent exposures to immunomodulators (cyclophosphamide, azathioprine, methotr
Export Processing Zones are geographical enclaves that have legally been excepted from the country´s normal customs barriers and other constraining legislations. Malaysia has used them to foster its manufacturing industries, particularly the electronic sector. They are intended to attract foreign exchange, create employment and increase exports. In a longer perspective they are also supposed to ha
The present essay examines the family policy of the current right winged government in Sweden and essentially two recently implemented incentives that aims at increasing the freedom to choose individual child-care as well as stimulating an increased gender equality both in the private- and the public sphere. The aim is to identify the ideology that permeates the family policy and from there critic
Purpose: Several tumor markers have recently been applied for prostate cancer screening. We analyze the effectiveness of prostate specific antigen (PSA), age specific PSA, PSA velocity, volume adjusted PSA densities, change in PSA level following antibacterial therapy, free-to-total PSA ratio, alpha1-antichymotrypsin bound PSA, alpha2-macroglobulin bound PSA, alpha1-protease inhibitor bound PSA an
Adsorption of uncharged homopolymers in good and theta solvents onto planar surfaces at various chain flexibility and polymer-surface attraction strengths was investigated by using a coarse-grained bead-spring polymer model and simulation techniques. Equilibrium properties of the interfacial systems were obtained from Monte Carlo simulations by monitoring the bead and polymer density profiles, the
Patent foramen ovale (PFO) is present in approximately 25% of the general population. PFO is characterized by intermittent shunting of blood from the right to the left atrium, especially in the context of increased right-sided filling pressures, with risk of paradoxical embolism. We describe a 69-year-old woman presenting with acute chest pain, severe dyspnoea, and acute inferolateral ST-segment e
Increased intraluminal pressure of the rat portal vein in vivo causes hypertrophy and altered contractility in 1 to 7 days. We have used organ cultures to investigate mechanisms involved in this adaptation to mechanical load. Strips of rat portal vein were cultured for 3 days, either undistended or loaded by a weight. Length-force relations were shifted toward longer length in stretched cultured v
Type 2 diabetes is characterised by both impaired insulin secretion and insulin resistance but their relative contribution to the development of hyperglycaemia may differ due to heterogeneity of the disease. Under most circumstances, insulin resistance is the earliest detectable defect in pre-diabetic individuals but it is not known whether this is the primary defect or secondary to other abnormal
Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic-based and population-based lymphoma registries
Popular Abstract in Swedish Bakgrund 5-Fluorouracil (5-FU) är ett cytostatikum, även kallat cellgift (ett ämne som hämmar tillväxten av cancerceller), som använts för behandling av cancersjukdom sedan många decennier. Det kan ges både i snabb injektion och i dropp över flera dygn. 5-FU har tyvärr flera vanliga biverkningar. Man kan få påverkan av slemhinnor i magtarm-kanalen, vilket ger sår i munnThe cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. In an animal model, treatment with thromboprophylactic doses of the low-molecular weight heparin (LMWH) dalteparin could
Prostate-specific antigen (PSA) and human prostatic glandular kallikrein (hK2) have 79% identity with the primary structure. When we used recombinant hK2 protein, only 7 of 23 monoclonal anti-PSA IgGs (monoclonal antibodies, MAbs) cross-reacted with hK2, which enabled us to design a novel immunofluorometric MAb-MAb assay for the specific detection of hK2. In the first incubation, an excess of MAb
This article is concerned with the historical evolution of the mining industry in Canada since 1859. The focus is directed on changes that occurred in the industry and allows for the identification of four distinct mining regimes. These regimes are defined using the Regulation Theory, which connects conditions of production, technical progress, financial structures, and social relations. The ident
BACKGROUND: Individuals adhering to a gluten-free diet (GFD) have been scarcely researched within a Chinese population. This present study was conducted to assess the characteristics, food choices, shopping preferences, and emotions and attitudes of individuals following a GFD.METHODS: Individuals following a GFD were invited to complete an online questionnaire about their demography and geography
The prostanoid thromboxane (TX)A2 plays a central role in haemostasis and is increasingly implicated in cancer progression. TXA2 signals through two T Prostanoid receptor (TP) isoforms termed TPa and TPβ, with both encoded by the TBXA2R gene. Despite exhibiting several functional and regulatory differences, the role of the individual TP isoforms in neoplastic diseases is largely unknown. This stud
Quantitative analysis of small angle neutron scattering (SANS) data from homogeneous multicomponent mixtures of supercritical carbon dioxide (scCO(2)) and two polymers is presented for the first time. The two polymers used in this study were styrene-acrylonitrile copolymer (SAN) and deuterated poly(methyl methacrylate) (dPMMA). Model polymers were used to facilitate comparisons between theory and
The effect of hydrophilically modified polystyrene, poly(styrene-g-poly(ethylene oxide)), P(S-g-PEC), on the viscosity of ACT oil-continuous microemulsions has been investigated as a function of PS and PEO chain lengths and PEO chain density. A series of polymers, P (S-g-PEO) with PEO chain lengths of 23 or 9, and different graft densities were synthesized by living radical polymerization. Thus, a
We examined herbivore-induced responses of alfalfa (Medicago sativa) and cotton (Gossypium hirsutum) under different CO2 conditions. Plants were grown under ambient (350 ppm) or elevated (700 ppm) CO2 levels, and were either damaged or undamaged by Spodoptera littoralis larvae. At harvest, growth of undamaged (control) plants was determined, and foliar chemical composition of both undamaged and da
